PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19050173-4 2009 Confirmation of the PAM activity of SB-206553 on the alpha7 nAChR was obtained in patch-clamp electrophysiological experiments in GH4C1 cells, where it failed to evoke any detectable currents when applied alone, yet dramatically potentiated the currents evoked by an EC(20) (17 microM) and EC(100) (124 microM) of acetylcholine (ACh). SB 206553 36-45 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 60-65