PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10504298-8 1999 To determine if K5-PKCalpha mice display an altered response to TPA-promotion, 7, 12-dimethylbenz[a]anthracene-initiated K5-PKCalpha mice and wild-type mice were promoted with TPA. anthracene 100-110 protein kinase C, alpha Mus musculus 124-132 22843879-0 2012 PKCalpha suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation. anthracene 40-50 protein kinase C, alpha Mus musculus 0-8 8242857-4 1993 A characteristic of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated papillomas, which contain an A-->T mutation in the 61st codon of Ha-ras, is that they exhibit a constitutive decrease in both protein kinase C (PKC) activity and PKC alpha and beta 2 isozyme levels when compared to epidermis. anthracene 40-50 protein kinase C, alpha Mus musculus 233-242 16103087-2 2005 PKCalpha-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12-dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) for tumor promotion. anthracene 156-166 protein kinase C, alpha Mus musculus 0-8 19118017-3 2009 Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors. anthracene 75-85 protein kinase C, alpha Mus musculus 21-29