PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28799955-7 2017 An intra-dPAG injection of the 5-HT1A receptor agonist (+-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) increased the [INCREMENT] threshold in both DBT and NGL, suggesting a panicolytic-like effect. dpag 9-13 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-37 28799955-8 2017 DBT animals presented a more pronounced panicolytic-like response compared with NGL as a higher [INCREMENT] threshold was observed after 8-OH-DPAT treatment, which could be a consequence of the increased expression of the 5-HT1A receptor in the dPAG from DBT animals. dpag 245-249 5-hydroxytryptamine receptor 1A Rattus norvegicus 222-228 20457188-2 2010 Cannabidiol (CBD), a major non-psychotomimetic compound present in Cannabis sativa, causes anxiolytic-like effects after intra-dPAG microinjections by activating 5-HT1A receptors. dpag 127-131 5-hydroxytryptamine receptor 1A Rattus norvegicus 162-168 23598399-3 2013 The obtained results showed that intra-dPAG administration of morphine significantly increased escape latency, a panicolytic-like effect that was blocked by pre-treatment with intra-dPAG injection of either naloxone or the 5-HT1A antagonist N-[2-[4-(2-methoxyphenyl)-1 piperazinyl] ethyl] -N- 2- pyridinyl-ciclohexanecarboxamide maleate (WAY-100635). dpag 39-43 5-hydroxytryptamine receptor 1A Rattus norvegicus 223-229 23598399-7 2013 These results suggest a synergic interaction between the 5-HT1A and the micro-opioid receptor at post-synaptic level on neurons of the dPAG that regulate proximal defense, theoretically related to panic attacks. dpag 135-139 5-hydroxytryptamine receptor 1A Rattus norvegicus 57-63 23787365-2 2013 In the dorsal periaqueductal gray matter (dPAG), another key panic-associated area, serotonin, through the activation of 5-HT1A and 5-HT2A receptors, exerts an inhibitory role on escape expression. dpag 42-46 5-hydroxytryptamine receptor 1A Rattus norvegicus 121-133 23787365-8 2013 The results indicate that 5-HT1A and 5-HT2A receptors within the DMH play a phasic inhibitory role upon escape expression, as previously reported in the dPAG. dpag 153-157 5-hydroxytryptamine receptor 1A Rattus norvegicus 26-38 23007604-5 2013 We also investigated if CBD effects on the ETM depend on facilitation of 5-HT1A-mediated neurotransmission in the DPAG. dpag 114-118 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-79 23007604-6 2013 To this latter aim, we verified if these effects would be prevented by intra-DPAG injection of the 5-HT1A receptor antagonist WAY100635 (0.37 nmol/0.2 muL). dpag 77-81 5-hydroxytryptamine receptor 1A Rattus norvegicus 99-105 23007604-7 2013 Also, we verified, by in vivo microdialysis, if CBD chronic treatment increases serotonin (5-HT) release and, by quantitative polymerase chain reaction, if there are changes in 5HT-1A or 5HT-2C mRNA expression in DPAG. dpag 213-217 5-hydroxytryptamine receptor 1A Rattus norvegicus 177-183 23007604-10 2013 CBD effects were prevented by DPAG injection of the 5-HT1A receptor antagonist. dpag 30-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 23007604-11 2013 CONCLUSIONS: Together, these findings suggest that repeated treatment with CBD induces anti-panic effects by acting on 5-HT1A receptors in DPAG. dpag 139-143 5-hydroxytryptamine receptor 1A Rattus norvegicus 119-125 25315826-1 2014 A wealth of evidence indicates that the activation of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal grey matter (dPAG) inhibits escape, a panic-related defensive behaviour. dpag 124-128 5-hydroxytryptamine receptor 1A Rattus norvegicus 54-66 20457188-9 2010 Together, the results suggest that CBD causes panicolytic effects in the dPAG by activating 5-HT1A receptors. dpag 73-77 5-hydroxytryptamine receptor 1A Rattus norvegicus 92-98 18076976-4 2008 The 5-HT1A function of the dPAG was evaluated by local injections of 8-OH-DPAT (4 and 8 nmol/0.2 microL) and WAY-100635 (10 nmol/0.2 microL), selective agonist and antagonist of 5-HT1A receptors, respectively. dpag 27-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 20478359-4 2010 The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl). dpag 30-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 74-81 18446327-10 2008 CONCLUSIONS: Alprazolam as antidepressants compounds facilitates 5-HT(1A)- and 5-HT(2A)-receptor-mediated neurotransmission in the DPAG, implicating this effect in the mode of action of different classes of antipanic drugs. dpag 131-135 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-72 18076976-4 2008 The 5-HT1A function of the dPAG was evaluated by local injections of 8-OH-DPAT (4 and 8 nmol/0.2 microL) and WAY-100635 (10 nmol/0.2 microL), selective agonist and antagonist of 5-HT1A receptors, respectively. dpag 27-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 178-184 18076976-9 2008 Also, the reduction in the regulation of the defensive behaviors by 5-HT1A-mediated mechanisms in the dPAG of these animals may underlie the stress precipitated psychopathology associated with the neural substrates of aversion of the dPAG. dpag 102-106 5-hydroxytryptamine receptor 1A Rattus norvegicus 68-74 18076976-9 2008 Also, the reduction in the regulation of the defensive behaviors by 5-HT1A-mediated mechanisms in the dPAG of these animals may underlie the stress precipitated psychopathology associated with the neural substrates of aversion of the dPAG. dpag 234-238 5-hydroxytryptamine receptor 1A Rattus norvegicus 68-74 17313964-1 2007 Behavioral evidence indicates that sensitization of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal gray (DPAG) may underlie the therapeutic effect of serotonin reuptake inhibitors (SRIs) in panic disorder. dpag 115-119 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-64 17313964-3 2007 In this test, chronic administration of the non-selective SRI imipramine enhances the inhibitory effect on escape caused by the intra-DPAG injection of the 5-HT1A receptor agonist 8-OH-DPAT. dpag 134-138 5-hydroxytryptamine receptor 1A Rattus norvegicus 156-162 17313964-8 2007 The results indicate that chronic administration of fluoxetine and sertraline sensitizes 5-HT1A receptors in the DPAG. dpag 113-117 5-hydroxytryptamine receptor 1A Rattus norvegicus 89-95 17313964-9 2007 Overall, they support the view that facilitation of 5-HT1A receptor-mediated neurotransmission in the DPAG is implicated in the therapeutic effect of SRIs on panic disorder. dpag 102-106 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 16231166-4 2005 We also investigated whether the 5-HT(1A) and 5-HT(2A) receptors in the DPAG mediate the behavioral consequences induced by the injection of WAY-100635 into the DRN. dpag 72-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 33-40 16170231-3 2005 In the present study we further explore the hypothesis that sensitization of 5-HT1A and 5-HT 2 A receptors in the DPAG is involved in the anti-panic effect of imipramine. dpag 114-118 5-hydroxytryptamine receptor 1A Rattus norvegicus 77-89 16170231-11 2005 Therefore, chronic imipramine seems to sensitize both 5-HT1A and 5-HT 2 A receptors in the DPAG, strengthening the view that these receptors are involved in the mode of action of anti-panic drugs. dpag 91-95 5-hydroxytryptamine receptor 1A Rattus norvegicus 54-66 12062564-6 2002 The results suggest that sensitization of both 5-HT(1A) and 5-HT(2) receptors within the DPAG may be involved in the beneficial effect of imipramine in panic disorder (PD). dpag 89-93 5-hydroxytryptamine receptor 1A Rattus norvegicus 47-54 15342106-5 2004 We presently evaluate the role of the 5-HT1A, 5-HT2A and 5-HT2C receptors of the DPAG in the modulation of inhibitory avoidance and escape responses of rats submitted to the elevated T-maze. dpag 81-85 5-hydroxytryptamine receptor 1A Rattus norvegicus 38-44 15342106-6 2004 The results showed that intra-DPAG administration of the 5-HT1A receptor antagonist WAY-100635 and of the preferential antagonists of 5-HT2A and 5-HT2C receptors, ketanserin and SDZ SER 082, respectively, did not change rat behavior in the elevated T-maze. dpag 30-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 57-63 15342106-9 2004 Intra-DPAG injection of the 5-HT1A agonist 8-OH-DPAT and of DOI, a preferential 5-HT2A agonist, also inhibited escape, an effect antagonized by WAY-100635 and ketanserin, respectively. dpag 6-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 15342106-11 2004 5-HT1A and 5-HT2C receptors in the DPAG play an opposite role in inhibitory avoidance: whereas activation of the former receptors inhibits the acquisition of this response, activation of the latter facilitates it. dpag 35-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 10475723-1 1999 Acute systemic administration of the selective serotonin (5-HT)1A receptor full agonist flesinoxan enhanced the sensitivity of rats to the panic-like aversion elicited by local stimulation of the dorsolateral periaqueductal grey (dPAG). dpag 230-234 5-hydroxytryptamine receptor 1A Rattus norvegicus 47-74 7501649-6 1995 These results indicate that activation of 5-HT1A and 5-HT2A receptors inhibits aversion in the DPAG and that both receptors have to be functional for the expression of each one"s activation to occur. dpag 95-99 5-hydroxytryptamine receptor 1A Rattus norvegicus 42-54