PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25840741-3 2015 In the present study we evaluated the participation of the BDNF-TRKB system of the dorsal periaqueductal gray matter (DPAG), a core structure involved in the pathophysiology of panic disorder, in AD-induced panicolytic-like effects in rats. dpag 118-122 brain-derived neurotrophic factor Rattus norvegicus 59-63 25840741-4 2015 The results showed that short- (3 days) or long-term (21 days) systemic treatment with the tricyclic ADs imipramine, clomipramine or desipramine increased BDNF levels in the DPAG. dpag 174-178 brain-derived neurotrophic factor Rattus norvegicus 155-159 25840741-11 2015 Altogether, our data suggests that facilitation of the BDNF-TRKB system in the DPAG is implicated in the panicolytic effect of ADs. dpag 79-83 brain-derived neurotrophic factor Rattus norvegicus 55-59 20047714-10 2010 Bicuculline also blocked the inhibitory effect of BDNF on mean arterial pressure increase caused by electrical stimulation of DPAG. dpag 126-130 brain-derived neurotrophic factor Rattus norvegicus 50-54 20047714-11 2010 Therefore, in the DPAG, BDNF-TrkB signalling interacts with the GABAergic system to cause a panicolytic-like effect. dpag 18-22 brain-derived neurotrophic factor Rattus norvegicus 24-28 30991078-2 2019 BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se when injected into the dPAG. dpag 126-130 brain-derived neurotrophic factor Rattus norvegicus 0-4 30991078-3 2019 Based on these findings, we hypothesize that nitric oxide synthase (NOS) inhibitors would have panicolytic properties associated with increased BDNF signaling in the dPAG. dpag 166-170 brain-derived neurotrophic factor Rattus norvegicus 144-148 20047714-4 2010 In this study we investigated the effect of intra-DPAG injection of BDNF in a proposed animal model of panic: the escape response evoked by the electrical stimulation of the same midbrain area. dpag 50-54 brain-derived neurotrophic factor Rattus norvegicus 68-72