PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29051323-4 2018 Derepression of BIM expression by depletion of ZEB1 or treatment with the BH3 mimetic ABT-263 to enhance "free" cellular BIM levels both led to resensitization of mesenchymal EGFR-mutant cancers to EGFRi. bim 16-19 epidermal growth factor receptor Homo sapiens 175-179 29212192-0 2017 Vorinostat and metformin sensitize EGFR-TKI resistant NSCLC cells via BIM-dependent apoptosis induction. bim 70-73 epidermal growth factor receptor Homo sapiens 35-39 26639561-1 2015 BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). bim 0-3 epidermal growth factor receptor Homo sapiens 68-72 26639561-10 2015 These data suggest that the combination of EGFR TKI with mTOR or PDE4 inhibitors could be adequate therapy for EGFR-mutant NSCLC patients with high pretreatment levels of BIM and mTOR. bim 171-174 epidermal growth factor receptor Homo sapiens 43-47 26639561-10 2015 These data suggest that the combination of EGFR TKI with mTOR or PDE4 inhibitors could be adequate therapy for EGFR-mutant NSCLC patients with high pretreatment levels of BIM and mTOR. bim 171-174 epidermal growth factor receptor Homo sapiens 111-115 23382048-2 2013 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim 0-3 epidermal growth factor receptor Homo sapiens 56-68 23382048-2 2013 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim 0-3 epidermal growth factor receptor Homo sapiens 70-74 23382048-2 2013 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim 0-3 epidermal growth factor receptor Homo sapiens 104-108 23382048-2 2013 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim 0-3 epidermal growth factor receptor Homo sapiens 104-108 34388376-0 2021 Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. bim 107-110 epidermal growth factor receptor Homo sapiens 63-67