PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19619936-4	2010	Moreover, BIM-23A760 and BIM-53097 induced ERK1/2 and p38 phosphorylation and the blockade of these pathways prevented both the antiproliferative and the pro-apoptotic effects of these drugs.	bim	10-13	mitogen-activated protein kinase 1	Homo sapiens	54-57	
19619936-4	2010	Moreover, BIM-23A760 and BIM-53097 induced ERK1/2 and p38 phosphorylation and the blockade of these pathways prevented both the antiproliferative and the pro-apoptotic effects of these drugs.	bim	25-28	mitogen-activated protein kinase 1	Homo sapiens	54-57	
27997540-16	2016	Both the MEK-ERK and AKT pathways also inactivate BIM, an essential molecule for steroid-induced cell death, and inhibit GSK3B, an important regulator of proapoptotic BIM.	bim	50-53	mitogen-activated protein kinase 1	Homo sapiens	13-16	
19773433-6	2009	Results indicate that inhibition of the MAPK/ERK kinase (MEK)/ERK pathway in HepG2 cells, which are refractory to the proapoptotic effects of TGF-beta, sensitizes them to cell death through a mitochondrial-dependent mechanism, coincident with increased levels of BIM and BMF, decreased levels of BCL-XL and MCL1, and BAX/BAK activation.	bim	263-266	mitogen-activated protein kinase 1	Homo sapiens	40-44	
19773433-6	2009	Results indicate that inhibition of the MAPK/ERK kinase (MEK)/ERK pathway in HepG2 cells, which are refractory to the proapoptotic effects of TGF-beta, sensitizes them to cell death through a mitochondrial-dependent mechanism, coincident with increased levels of BIM and BMF, decreased levels of BCL-XL and MCL1, and BAX/BAK activation.	bim	263-266	mitogen-activated protein kinase 1	Homo sapiens	45-48	
19773433-6	2009	Results indicate that inhibition of the MAPK/ERK kinase (MEK)/ERK pathway in HepG2 cells, which are refractory to the proapoptotic effects of TGF-beta, sensitizes them to cell death through a mitochondrial-dependent mechanism, coincident with increased levels of BIM and BMF, decreased levels of BCL-XL and MCL1, and BAX/BAK activation.	bim	263-266	mitogen-activated protein kinase 1	Homo sapiens	62-65	
18523273-8	2008	TRAF1-deficient CD8 T cells fail to activate ERK in response to 4-1BB ligation and inhibition of ERK signaling downstream of 4-1BB in wild-type cells leads to increased Bim levels.	bim	169-172	mitogen-activated protein kinase 1	Homo sapiens	97-100	
17151701-11	2007	BIM(EL) phosphorylation through the ERK pathway targets the protein for proteasomal degradation.	bim	0-3	mitogen-activated protein kinase 1	Homo sapiens	36-39	
32291856-9	2020	We found that CH5126766 and R428 suppressed the phosphorylation of ERK and AKT, respectively, and their combination synergistically inhibited the growth of both cell lines with enhancement of apoptosis accompanied by the Bim upregulation.	bim	221-224	mitogen-activated protein kinase 1	Homo sapiens	67-70	
25915848-5	2016	Mechanistically, PXN-mediated extracellular signal-regulated kinases (ERK) activation is responsible for TKI resistance via decreased Bcl2-interacting mediator of cell death (BIM) and increased Mcl-1 expression due to modulating their protein stabilities by phosphorylation of BIM at serine 69 and Mcl-1 at threonine 163.	bim	175-178	mitogen-activated protein kinase 1	Homo sapiens	30-68	
25915848-5	2016	Mechanistically, PXN-mediated extracellular signal-regulated kinases (ERK) activation is responsible for TKI resistance via decreased Bcl2-interacting mediator of cell death (BIM) and increased Mcl-1 expression due to modulating their protein stabilities by phosphorylation of BIM at serine 69 and Mcl-1 at threonine 163.	bim	175-178	mitogen-activated protein kinase 1	Homo sapiens	70-73