PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18806830-5 2008 BIM is de-phosphorylated and upregulated following MEK1/2 inhibition in all CRC cell lines studied and knockdown of BIM reduces cell death, indicating that repression of BIM is a major part of the ability of BRAF(V600E) to confer growth factor-independent survival. bim 0-3 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 208-213