PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21056473-1 2011 In this study we investigate the feasibility of generating self-adjuvanting vaccines capable of inducing high titre antibody responses following the covalent attachment of the TLR2 agonist Pam(2)Cys to intact proteins. S-(2,3-bis(palmitoyloxy)propyl)cysteine 189-198 toll-like receptor 2 Mus musculus 176-180 15787968-3 2005 The structurally related lipopeptides with a head group lacking the fatty acyl residue at the amino-terminus (Pam(2)Cys) stimulate TLR2 and 6. S-(2,3-bis(palmitoyloxy)propyl)cysteine 110-119 toll-like receptor 2 Mus musculus 131-135 32380167-4 2020 Novel oral vaccines consisting of a long tumour peptide and the TLR2 (Toll-like receptor 2) ligand Pam2Cys, formulated in either liposomes or W/O/W double emulsions, were developed. S-(2,3-bis(palmitoyloxy)propyl)cysteine 99-106 toll-like receptor 2 Mus musculus 64-68 32380167-4 2020 Novel oral vaccines consisting of a long tumour peptide and the TLR2 (Toll-like receptor 2) ligand Pam2Cys, formulated in either liposomes or W/O/W double emulsions, were developed. S-(2,3-bis(palmitoyloxy)propyl)cysteine 99-106 toll-like receptor 2 Mus musculus 70-90 30396012-5 2018 We show that administration of PEG-Pam2Cys, a soluble form of the TLR2 agonist S-[2,3-bis(palmitoyloxy)propyl] cysteine (Pam2Cys), significantly and dramatically reduces the numbers of malaria parasites that grow in the livers of mice following subsequent challenge with sporozoites. S-(2,3-bis(palmitoyloxy)propyl)cysteine 79-119 toll-like receptor 2 Mus musculus 66-70 30396012-5 2018 We show that administration of PEG-Pam2Cys, a soluble form of the TLR2 agonist S-[2,3-bis(palmitoyloxy)propyl] cysteine (Pam2Cys), significantly and dramatically reduces the numbers of malaria parasites that grow in the livers of mice following subsequent challenge with sporozoites. S-(2,3-bis(palmitoyloxy)propyl)cysteine 35-42 toll-like receptor 2 Mus musculus 66-70 31740096-2 2020 In the first, the Toll-like receptor 2 agonist Pam2Cys and the target antibody epitope are assembled as a module which is then coupled to a carrier protein as a source of antigens to stimulate T cell help. S-(2,3-bis(palmitoyloxy)propyl)cysteine 47-54 toll-like receptor 2 Mus musculus 18-38 29575556-6 2018 To increase the affinity of the developed lipopeptides for the negatively charged plasma membrane, a cationic polypeptide was connected to Pam2Cys (P2C), which is the basic structure of the TLR2 ligand. S-(2,3-bis(palmitoyloxy)propyl)cysteine 139-146 toll-like receptor 2 Mus musculus 190-194