PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26822586-5	2016	We hypothesize that ZnPP may modulate HIF-1alpha through inhibiting HO-1, and then inhibit angiogenesis and tumor progression.	zinc protoporphyrin	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48	
34874275-6	2021	However, addition of the competitive HO-1 inhibitor ZnPP resulted in an increase in HIF1A expression.	zinc protoporphyrin	52-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-89	
26822586-11	2016	Moreover, we observed that the HO-1 inhibitor ZnPP inhibited the expressions of HIF-1alpha and VEGF coupled with cell proliferations of HCT-15 cells, suggesting that ZnPP blocked HIF-1alpha expression, and then inhibited the consequent VEGF production.	zinc protoporphyrin	46-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90	
26822586-11	2016	Moreover, we observed that the HO-1 inhibitor ZnPP inhibited the expressions of HIF-1alpha and VEGF coupled with cell proliferations of HCT-15 cells, suggesting that ZnPP blocked HIF-1alpha expression, and then inhibited the consequent VEGF production.	zinc protoporphyrin	46-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-189	
26822586-11	2016	Moreover, we observed that the HO-1 inhibitor ZnPP inhibited the expressions of HIF-1alpha and VEGF coupled with cell proliferations of HCT-15 cells, suggesting that ZnPP blocked HIF-1alpha expression, and then inhibited the consequent VEGF production.	zinc protoporphyrin	166-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90	
26822586-11	2016	Moreover, we observed that the HO-1 inhibitor ZnPP inhibited the expressions of HIF-1alpha and VEGF coupled with cell proliferations of HCT-15 cells, suggesting that ZnPP blocked HIF-1alpha expression, and then inhibited the consequent VEGF production.	zinc protoporphyrin	166-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-189	
26822586-14	2016	The HO-1 inhibitor, ZnPP, possessed the properties of anti-tumor agent by decreasing HIF-1alpha levels, blocking VEGF production, impairing tumor angiogenesis, and inhibiting tumor growth.	zinc protoporphyrin	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95	
21206978-9	2011	Hypoxic conditions induced upregulation of HO-1, VEGF, HIF-1alpha, HIF-2alpha, and COX-2 in T24 cells and increased VEGF secretion, which could be suppressed by zinc protoporphyrin IX.	zinc protoporphyrin	161-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65	
20021945-9	2009	In addition, the HO-1 overexpression under hypoxia was decreased by HIF-1alpha inhibitor, while the HIF-1alpha expression level under hypoxia was not significantly changed after HO-1 expression was inhibited by ZnPPIX.	zinc protoporphyrin	211-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110	
21413014-11	2012	Moreover, treatment of protoporphyrin IX, ZnPP or Co(III)PP, but not Mn(III)PP, inhibited HIF-1alpha induction, indicating that protoporphyrin ring in association with the nature of binding metal leads to HSP90 inhibition.	zinc protoporphyrin	42-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100