PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1834175-2	1991	Since synexin from adrenal glands promotes aggregation and fusion of chromaffin granules, we purified synexin-like proteins from bovine lung cytosolic fraction, and evaluated their effect on the fusion of isolated lamellar bodies and plasma membrane fractions.	chromaffin	69-79	annexin A7	Bos taurus	6-13	
6112701-3	1980	We have discovered and isolated a new 47,000 MW protein (synexin) from adrenal medulla tissue that fuses chromaffin granule membranes only in the presence of calcium.	chromaffin	105-115	annexin A7	Bos taurus	57-64	
6112701-4	1980	Synexin activity was detected in a number of secretory tissues including human platelets and bovine brain, and the synexin molecule was found by immunofluorescent cytochemistry to be localized to the cytoplasm of chromaffin cells.	chromaffin	213-223	annexin A7	Bos taurus	115-122	
1423500-0	1992	Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: evidence for a dynamic role in the secretory process.	chromaffin	55-65	annexin A7	Bos taurus	22-29	
1423500-0	1992	Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: evidence for a dynamic role in the secretory process.	chromaffin	55-65	annexin A7	Bos taurus	31-42	
1423500-2	1992	Using a monoclonal antibody against synexin, Mab 10E7, and immunogold, we carried out a semiquantitative localization study of synexin in bovine adrenal medullary chromaffin granules, and in resting and nicotine-stimulated adrenal chromaffin cells.	chromaffin	163-173	annexin A7	Bos taurus	127-134	
1423500-3	1992	Isolated chromaffin granules contained very little synexin, whereas chromaffin granules aggregated with synexin (24 micrograms/mg) and Ca2+ (1 mM) clearly showed synexin-associated immunogold particles in the vicinity of the granule membrane (1.88 gold particles per granule profile).	chromaffin	68-78	annexin A7	Bos taurus	104-111	
1423500-3	1992	Isolated chromaffin granules contained very little synexin, whereas chromaffin granules aggregated with synexin (24 micrograms/mg) and Ca2+ (1 mM) clearly showed synexin-associated immunogold particles in the vicinity of the granule membrane (1.88 gold particles per granule profile).	chromaffin	68-78	annexin A7	Bos taurus	104-111	
1423500-7	1992	We conclude that synexin is involved in the secretory process in chromaffin cells.	chromaffin	65-75	annexin A7	Bos taurus	17-24	
2974861-3	1988	Synexin is a 47,000 Mr calcium-binding protein, initially discovered in the bovine adrenal medulla, which binds to granule membranes and to inner aspects of chromaffin cell plasma membranes.	chromaffin	157-167	annexin A7	Bos taurus	0-7	
2974861-4	1988	Synexin causes chromaffin granules to aggregate, and such aggregates can be caused to fuse in the additional presence of arachidonic acid.	chromaffin	15-25	annexin A7	Bos taurus	0-7	
2974861-5	1988	Synexin also mediates the direct fusion of liposomes and chromaffin granule ghosts.	chromaffin	57-67	annexin A7	Bos taurus	0-7	
2960380-0	1987	Synexin-mediated fusion of bovine chromaffin granule ghosts.	chromaffin	34-44	annexin A7	Bos taurus	0-7	
2960380-2	1987	Synexin induces chromaffin granule ghosts to fuse one to another, a process which is followed continuously and quantitatively by monitoring the mixing of the intragranular aqueous compartments.	chromaffin	16-26	annexin A7	Bos taurus	0-7	
2960380-14	1987	We conclude that the coincident pCa and pH sensitivity of synexin-mediated binding to chromaffin granule membranes and their subsequent fusion might be associated with physiological changes in the concentration of both cations in the cytoplasm of secreting chromaffin cells.	chromaffin	86-96	annexin A7	Bos taurus	58-65	
2960380-14	1987	We conclude that the coincident pCa and pH sensitivity of synexin-mediated binding to chromaffin granule membranes and their subsequent fusion might be associated with physiological changes in the concentration of both cations in the cytoplasm of secreting chromaffin cells.	chromaffin	257-267	annexin A7	Bos taurus	58-65	
6121822-0	1982	Further characterization of the aggregation and fusion of chromaffin granules by synexin as a model for compound exocytosis.	chromaffin	58-68	annexin A7	Bos taurus	81-88	
6121822-1	1982	Synexin was isolated from bovine liver and found to aggregate adrenal chromaffin granules in the same Ca2+-dependent manner as previously described for adrenal synexin.	chromaffin	70-80	annexin A7	Bos taurus	0-7	
6121822-2	1982	The chromaffin granule aggregating activity of liver synexin was blocked in vitro by the addition of an antibody prepared to the 47,000 molecular weight band extracted from an SDS gel of an adrenal medullary synexin preparation.	chromaffin	4-14	annexin A7	Bos taurus	53-60	
6121822-2	1982	The chromaffin granule aggregating activity of liver synexin was blocked in vitro by the addition of an antibody prepared to the 47,000 molecular weight band extracted from an SDS gel of an adrenal medullary synexin preparation.	chromaffin	4-14	annexin A7	Bos taurus	208-215	
6121822-3	1982	Chromaffin granules aggregated by synexin fused when exposed to cis-unsaturated fatty acids at concentrations comparable to those released from phospholipids by stimulated secretory cells.	chromaffin	0-10	annexin A7	Bos taurus	34-41	
6121822-5	1982	The aggregation and fusion of chromaffin granules thus appears to be a useful model system for studying synexin from diverse tissues and for testing pharmacologically or toxicologically active substances for effects on secretory systems.	chromaffin	30-40	annexin A7	Bos taurus	104-111