PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27648599-4 2016 A series of the ligands, alpha-galactosyl ceramide (alpha-GalCer) derivatives containing polar groups in the acyl chain, was synthesized, and the structure-activity relationship studies demonstrated that simple modification from a methylene to an amide group in the long fatty acyl chain, when introduced at optimal positions, enhanced the CD1d recognition of the glycolipid ligands. Amides 45-50 CD1d molecule Homo sapiens 340-344 28655912-4 2017 While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the studied alpha-galactosylsphingamides showed compromised antigenic properties. Amides 26-31 CD1d molecule Homo sapiens 85-89