PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26141771-12	2015	The amides showed highly improved hERG (functional IC50 >30 muM) profile.	Amides	4-10	ETS transcription factor ERG	Homo sapiens	34-38	
26804230-2	2016	Herein we describe our work to eliminate this hERG activity via alteration of the substituents on the benzoic amide functionality.	Amides	110-115	ETS transcription factor ERG	Homo sapiens	46-50	
20570511-3	2010	These studies led to the discovery of amide 24 which showed good c-Met inhibitory potency, low affinity to hERG and favorable pharmacokinetic properties in rats.	Amides	38-43	ETS transcription factor ERG	Homo sapiens	107-111	
24486132-1	2014	Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles.	Amides	64-69	ETS transcription factor ERG	Homo sapiens	95-99	
24412109-2	2014	Among the structurally modified compounds we designed, compounds 5 and 6, which incorporate amides in place of the original compound"s amines, most appreciably alleviated hERG toxicity while maintaining T-type calcium channel blocking activity.	Amides	92-98	ETS transcription factor ERG	Homo sapiens	171-175	
21515049-2	2011	In continuation of our research in this area, macrocyclic amides and lactams were explored to reduce the risk of hERG liabilities.	Amides	58-64	ETS transcription factor ERG	Homo sapiens	113-117	
20684603-2	2010	Further study revealed that by replacing the aryl substitution on the imidazole ring with a more polar carboxylic ester or amide, these compounds displayed not only increased DPP4 binding activity but also significantly reduced human ether-a-go-go related gene (hERG) and sodium channel inhibitory activities.	Amides	123-128	ETS transcription factor ERG	Homo sapiens	262-266	
21414780-4	2011	Increasing the acidity of the amide proton by converting the benzamide in lead 1 to an anilide provided single digit nanomolar MCHR1 antagonists while replacing the dimethoxyphenyl ring of 1 with alkyl groups possessing increased polarity dramatically reduced the hERG inhibition.	Amides	30-35	ETS transcription factor ERG	Homo sapiens	264-268	
34413963-2	2021	Among 46 analogues tested, compounds 21, 30, and 33 displayed high activities against asexual blood stage parasites (PfNF54 IC50 = 0.025-0.043 muM), whereas amide compound 46 additionally showed activity against late-stage gametocytes (stage IV/V; PfLG IC50 = 0.6 +- 0.1 muM) and 860-fold higher selectivity over hERG (46, SI = 43) compared to AST.	Amides	157-162	ETS transcription factor ERG	Homo sapiens	313-317	
19821563-3	2009	As the substituent on the amide was increased in lipophilicity the potency and hERG inhibition increased, while polar groups lowered potency, without significantly impacting hERG inhibition.	Amides	26-31	ETS transcription factor ERG	Homo sapiens	79-83