PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28805792-7 2017 (iii) A CD4/CD8 ratio less than 0.567 on day 30 post transplantation was associated with higher overall survival after haplo-SCT in SAA patients. saa 132-135 CD8a molecule Homo sapiens 12-15 29115638-7 2018 Finally, the correlation between telomere length and these functional events of CD8+T lymphocytes was analyzed in patients with SAA. saa 128-131 CD8a molecule Homo sapiens 80-83 29115638-8 2018 The results showed that RTLs of CD8+T lymphocytes in SAA were significantly shorter compared with those in controls. saa 53-56 CD8a molecule Homo sapiens 32-35 29115638-9 2018 Furthermore, in patients with SAA, CD8+T lymphocytes are associated with T cell hyper-function, which is related to the RTL. saa 30-33 CD8a molecule Homo sapiens 35-38 29115638-10 2018 Thus, the shorter RTLs of CD8+T lymphocytes in SAA may be associated with hyper-function of these cells, which contribute to the pathogenesis of SAA. saa 47-50 CD8a molecule Homo sapiens 26-29 29115638-10 2018 Thus, the shorter RTLs of CD8+T lymphocytes in SAA may be associated with hyper-function of these cells, which contribute to the pathogenesis of SAA. saa 145-148 CD8a molecule Homo sapiens 26-29 30653151-9 2019 For all SAA patients, the percentage of T regulatory cells in CD4 lymphocyte was higher in post-IST group compared to the pretreatment group.For SAA patients responded well to IST, increase in peripheral neutrophils and improvement in bone marrow myeloid cells were first observed followed reduction in the activated CD8 T cell percentage, Th1/Th2 ratio, CD4/CD8T ratio, along with mDC/pDC ratio, all of which negatively correlated with the hematopoietic parameters. saa 145-148 CD8a molecule Homo sapiens 317-320 30486590-1 2018 Objective: To explore the expression of SLAMF6 on CD8(+) T cells in patients with severe aplastic anemia (SAA) and its correlation with disease immune status. saa 106-109 CD8a molecule Homo sapiens 50-53 30486590-2 2018 Methods: By flow cytometry (FCM), SLAMF6 expression level in peripheral blood CD8(+) T cells was detected in 21 patients with SAA and 15 normal controls respectively from February 2017 to April 2018. saa 126-129 CD8a molecule Homo sapiens 78-81 30486590-5 2018 Results: The expression of SLAMF6 on CD8(+) T cells in untreated SAA patients[(56.29+-12.97)%]was significantly lower than that of normal controls[(80.96+-7.36)%](t=-7.672, P<0.001). saa 65-68 CD8a molecule Homo sapiens 37-40 30486590-8 2018 Conclusions: SLAMF6 is significantly down-regulated on CD8(+) T cells in SAA patients, which may act as a negative immunoregulatory molecule participating in the mechanism of SAA by affecting the functional molecules secretion on CD8(+) T cells. saa 73-76 CD8a molecule Homo sapiens 55-58 30486590-8 2018 Conclusions: SLAMF6 is significantly down-regulated on CD8(+) T cells in SAA patients, which may act as a negative immunoregulatory molecule participating in the mechanism of SAA by affecting the functional molecules secretion on CD8(+) T cells. saa 73-76 CD8a molecule Homo sapiens 230-233 30486590-8 2018 Conclusions: SLAMF6 is significantly down-regulated on CD8(+) T cells in SAA patients, which may act as a negative immunoregulatory molecule participating in the mechanism of SAA by affecting the functional molecules secretion on CD8(+) T cells. saa 175-178 CD8a molecule Homo sapiens 55-58 28805792-8 2017 In conclusion, SAA patients showed a faster recovery of monocytes and CD8+ T cells after haplo-SCT, whereas the recovery of the CD4+ T-cell subset was delayed. saa 15-18 CD8a molecule Homo sapiens 70-73 26097547-6 2015 The ratio of CD4+ memory T lymphocytes to CD8+ memory T subsets (CD4+/CD8+TM) in SAA patients was also lower. saa 81-84 CD8a molecule Homo sapiens 42-45 27485471-2 2016 In the present study, we evaluated histone H3 acetylation levels of bone marrow CD8+ T cells in SAA patients, and analyzed its correlation with clinical condition parameters. saa 96-99 CD8a molecule Homo sapiens 80-83 27485471-3 2016 We found that the percentages of CD8+ T cell histone H3 acetylation in patients with untreated SAA, recovering SAA (R-SAA) and normal control, were 1.21 +- 0.08, 1.05 +- 0.36, and 1.00 +- 0.41, respectively, with no significant statistical differences. saa 95-98 CD8a molecule Homo sapiens 33-36 27485471-3 2016 We found that the percentages of CD8+ T cell histone H3 acetylation in patients with untreated SAA, recovering SAA (R-SAA) and normal control, were 1.21 +- 0.08, 1.05 +- 0.36, and 1.00 +- 0.41, respectively, with no significant statistical differences. saa 111-114 CD8a molecule Homo sapiens 33-36 27485471-4 2016 However, the amount of CD8+ T cell histone H3 acetylation from untreated SAA was 176.21 +- 32.22 mug/mg protein, which was significantly higher than that of complete response (CR)-SAA (104.29 +- 62.06 mug/mg protein) and normal control (133.94 +- 56.27 mug/mg protein) (P < 0.05) groups. saa 73-76 CD8a molecule Homo sapiens 23-26 27485471-7 2016 Abnormal histone H3 acetylation of CD8+ T cells may thus play a role in the immune pathogenesis of SAA. saa 99-102 CD8a molecule Homo sapiens 35-38 26097547-6 2015 The ratio of CD4+ memory T lymphocytes to CD8+ memory T subsets (CD4+/CD8+TM) in SAA patients was also lower. saa 81-84 CD8a molecule Homo sapiens 70-73 24673455-9 2014 In patients with SAA, the expression of LAT was positively associated with the expression of perforin and granzyme B in CD8(+) T cells. saa 17-20 CD8a molecule Homo sapiens 120-123 24673455-10 2014 Inhibition of LAT expression in T cells from patients with SAA decreased the activation of the CD4(+) and CD8(+) T-cell subsets. saa 59-62 CD8a molecule Homo sapiens 106-109 1715221-10 1991 In conclusion, T-cell clones from SAA patients exhibit predominantly a CD8+ phenotype, a greater cytotoxic activity, and can be shown to produce greater quantities of suppressor lymphokines when compared with controls. saa 34-37 CD8a molecule Homo sapiens 71-74 24028719-11 2013 The expression of TNF-beta in SAA was negatively correlated with the percentage of reticulocyte and the ratio of CD4(+) T cell and CD8(+) T cell, positively correlated with the percentage of lymphocyte in peripheral blood count (r = -0.86, -0.90, 0.77, all P < 0.05). saa 30-33 CD8a molecule Homo sapiens 131-134 24028719-12 2013 CONCLUSIONS: IL-2 can enhance the proliferation and expression of TNF-beta of CD8(+)HLA-DR(+)T cells from SAA patients. saa 106-109 CD8a molecule Homo sapiens 78-81 22944154-1 2012 OBJECTIVE: To explore the regulative factors on CD8(+)HLA-DR(+) T cells in the patients with severe aplastic anemia (SAA) and examine the roles of these cells in the immunopathogenesis of SAA. saa 117-120 CD8a molecule Homo sapiens 48-51 22944154-1 2012 OBJECTIVE: To explore the regulative factors on CD8(+)HLA-DR(+) T cells in the patients with severe aplastic anemia (SAA) and examine the roles of these cells in the immunopathogenesis of SAA. saa 188-191 CD8a molecule Homo sapiens 48-51 18928602-5 2008 The levels of CD3(+) CD8(+) T cells in SAA group and MAA group were significantly higher than those in controls (p < 0.05). saa 39-42 CD8a molecule Homo sapiens 21-24 24969051-1 2014 The aim of the present study was to investigate the number and function of CD8+HLA-DR+ cells, which are considered to be activated cytotoxic T lymphocytes (CTLs), in peripheral blood to further examine the pathogenesis of severe aplastic anemia (SAA). saa 246-249 CD8a molecule Homo sapiens 75-78 24969051-8 2014 The proportion of CD8+HLA-DR+ T cells was analyzed by flow cytometry in peripheral blood and was identified to be significantly higher in untreated SAA than in remission patients and in the controls. saa 148-151 CD8a molecule Homo sapiens 18-21 24969051-9 2014 The expression of perforin, granzyme B, TNF-beta and FasL in CD8+HLA-DR+ T cells was analyzed by flow cytometry and PCR, which revealed increased expression in the untreated SAA group compared with that in the control group. saa 174-177 CD8a molecule Homo sapiens 61-64 24969051-10 2014 Furthermore, the apoptosis of CD3- bone marrow cells from normal individuals was enhanced following co-culture with CD8+HLA-DR+ T cells from untreated SAA patients. saa 151-154 CD8a molecule Homo sapiens 116-119 24969051-11 2014 In conclusion, the present study demonstrated that CD8+HLA-DR+ T cells may contribute to bone marrow failure in SAA. saa 112-115 CD8a molecule Homo sapiens 51-54 24938700-6 2014 FasL expression of CD8(+) cells was significantly higher in the newly diagnosed SAA group (89.53 +- 45.68%) than the remission (56.39 +- 27.94%; P < 0.01) and control (48.63 +- 27.38%; P <0.01) groups. saa 80-83 CD8a molecule Homo sapiens 19-22 22883060-2 2012 METHODS: The CD8(+)HLA-DR(+) cells were sorted by immunomagnetic separation from the PB of 24 untreated SAA patients and 23 normal controls. saa 104-107 CD8a molecule Homo sapiens 13-16 22883060-5 2012 The mRNA level of FasL in CD8(+)HLA-DR(+) T cells of untreated SAA patients was higher than that of the controls (0.77 +- 0.24 vs 0.61 +- 0.16, P = 0.011). saa 63-66 CD8a molecule Homo sapiens 26-29 22883060-6 2012 The mRNA of TNF-beta in CD8(+)HLA-DR(+) T cells of untreated SAA patients was also higher than that of the controls (0.58 +- 0.16 vs 0.46 +- 0.15, P = 0.011). saa 61-64 CD8a molecule Homo sapiens 24-27 34619854-15 2021 The expression of perforin in CD8+T cells in tacrolimus group was significantly lower than that in SAA group ((18. saa 99-102 CD8a molecule Homo sapiens 30-33