PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25441157-1	2014	In this paper, we have synthesized hyperbranched polyester microspheres with carboxylic acid functional groups (HBPE-CA) and developed a label-free electrochemical aptamer biosensor using thrombin-binding aptamer (TBA) as receptor for the measurement of thrombin in whole blood.	Carboxylic Acids	77-92	coagulation factor II, thrombin	Homo sapiens	188-196	
10201825-1	1999	An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been developed.	Carboxylic Acids	125-141	coagulation factor II, thrombin	Homo sapiens	74-89	
15348232-2	2001	Hirudin can block the active site of thrombin by means of its carboxylic acid reaction with the active regime of thrombin, and becomes a tightly bound complex, and thus controls the formation of thrombus.	Carboxylic Acids	62-77	coagulation factor II, thrombin	Homo sapiens	37-45	
15348232-2	2001	Hirudin can block the active site of thrombin by means of its carboxylic acid reaction with the active regime of thrombin, and becomes a tightly bound complex, and thus controls the formation of thrombus.	Carboxylic Acids	62-77	coagulation factor II, thrombin	Homo sapiens	113-121	
11513858-4	2001	Leu167 is important for the interaction with alpha(4) integrins, as is the C-terminal carboxylic acid of Arg168 exposed by thrombin cleavage.	Carboxylic Acids	86-101	coagulation factor II, thrombin	Homo sapiens	123-131	
11055335-3	2000	N-Terminal truncation resulted in tetrapeptides containing a C-terminal carboxylic acid, which exhibited low micromolar activity against the HCV serine protease.	Carboxylic Acids	72-87	coagulation factor II, thrombin	Homo sapiens	145-160