PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30327144-6 2018 we identified mitochondrial outer membrane proteins voltage-dependent anion channel (VDAC) 1 and VDAC2 as novel molecular targets of sulindac sulfone, and sulindac sulfone directly bound to both VDAC1 and VDAC2. sulindac sulfone 133-149 voltage dependent anion channel 2 Homo sapiens 97-102 30327144-6 2018 we identified mitochondrial outer membrane proteins voltage-dependent anion channel (VDAC) 1 and VDAC2 as novel molecular targets of sulindac sulfone, and sulindac sulfone directly bound to both VDAC1 and VDAC2. sulindac sulfone 155-171 voltage dependent anion channel 2 Homo sapiens 205-210 30327144-9 2018 Interestingly, these effects were consistent with those of sulindac sulfone against human colon cancer cells, suggesting that sulindac sulfone negatively regulates the function of VDAC1 and VDAC2. sulindac sulfone 126-142 voltage dependent anion channel 2 Homo sapiens 190-195 30327144-10 2018 In the present study, our data suggested that VDAC1 and VDAC2 are direct targets of sulindac sulfone which suppresses the mTORC1 pathway and induces G1 arrest. sulindac sulfone 84-100 voltage dependent anion channel 2 Homo sapiens 56-61