PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	82-98	prostaglandin-endoperoxide synthase 2	Homo sapiens	223-228	
21763448-7	2011	(R)-flurbiprofen and sulindac sulfone, COX-2 inactive analogs, also stimulated 15-PGDH activity indicating induction of 15-PGDH is independent of COX-2 inhibition.	sulindac sulfone	21-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44	
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	111-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	223-228	
11118042-0	2000	Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.	sulindac sulfone	0-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-58