PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20332437-0	2010	Sulindac sulfone induces a decrease of beta-catenin in HNSCC.	sulindac sulfone	0-16	catenin beta 1	Homo sapiens	39-51	
20332437-7	2010	In the present study, we surveyed the concentration of beta-catenin in an HNSCC line after incubation with different concentrations of sulindac sulfone.	sulindac sulfone	135-151	catenin beta 1	Homo sapiens	55-67	
20332437-9	2010	RESULTS: At 100 microMol of sulindac sulfone, a decrease in beta-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted beta-catenin.	sulindac sulfone	28-44	catenin beta 1	Homo sapiens	60-72	
20332437-9	2010	RESULTS: At 100 microMol of sulindac sulfone, a decrease in beta-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted beta-catenin.	sulindac sulfone	136-152	catenin beta 1	Homo sapiens	195-207	
20332437-12	2010	CONCLUSION: In this study, sulindac sulfone reduced levels of secreted beta-catenin in the HNSCC cell line UM-SCC 11A after 48 hours of incubation.	sulindac sulfone	27-43	catenin beta 1	Homo sapiens	71-83	
17416281-0	2007	Sulindac sulfone modulates beta-catenin in human cholesteatoma cell culture.	sulindac sulfone	0-16	catenin beta 1	Homo sapiens	27-39	
17416281-9	2007	RESULTS: After 48 h incubation with 400 micromol sulindac sulfone, the average level of beta-catenin showed a decrease of 46% (0.004337 microg/mL) from those determined at 16 h with the same concentration of sulindac sulfone.	sulindac sulfone	49-65	catenin beta 1	Homo sapiens	88-100	
17416281-9	2007	RESULTS: After 48 h incubation with 400 micromol sulindac sulfone, the average level of beta-catenin showed a decrease of 46% (0.004337 microg/mL) from those determined at 16 h with the same concentration of sulindac sulfone.	sulindac sulfone	208-224	catenin beta 1	Homo sapiens	88-100	
16820902-9	2006	Immunohistochemical and Western blot analyses were then performed, with different concentrations of sulindac sulfone (100, 200, 400, 600, and 800 microMol) for 48 h. At 400 microMol of sulindac sulfone a decrease of 21% was observed; at 600 microMol, 44% decrease of beta-catenin concentration was seen, and incubation with 800 microMol resulted in 73% reduction of secreted beta-catenin.	sulindac sulfone	185-201	catenin beta 1	Homo sapiens	267-279	
16820902-9	2006	Immunohistochemical and Western blot analyses were then performed, with different concentrations of sulindac sulfone (100, 200, 400, 600, and 800 microMol) for 48 h. At 400 microMol of sulindac sulfone a decrease of 21% was observed; at 600 microMol, 44% decrease of beta-catenin concentration was seen, and incubation with 800 microMol resulted in 73% reduction of secreted beta-catenin.	sulindac sulfone	185-201	catenin beta 1	Homo sapiens	375-387	
16382042-0	2005	Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.	sulindac sulfone	0-16	catenin beta 1	Homo sapiens	49-61	
16382042-4	2005	Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells.	sulindac sulfone	0-16	catenin beta 1	Homo sapiens	149-161	
16382042-7	2005	These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin.	sulindac sulfone	28-44	catenin beta 1	Homo sapiens	66-78	
16382042-7	2005	These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin.	sulindac sulfone	28-44	catenin beta 1	Homo sapiens	169-181	
15476853-4	2004	Additional enthusiasm for this approach is provided by data from several groups, which indicate that sulindac, sulindac sulfone and indomethacin can modulate the subcellular localization of beta-catenin in vivo, resulting in either decreased nuclear compartmentalization or enhanced localization of beta-catenin to the plasma membrane.	sulindac sulfone	111-127	catenin beta 1	Homo sapiens	190-202	
15476853-4	2004	Additional enthusiasm for this approach is provided by data from several groups, which indicate that sulindac, sulindac sulfone and indomethacin can modulate the subcellular localization of beta-catenin in vivo, resulting in either decreased nuclear compartmentalization or enhanced localization of beta-catenin to the plasma membrane.	sulindac sulfone	111-127	catenin beta 1	Homo sapiens	299-311	
14555707-7	2003	Inhibition of proteasome activity with MG-132 partially blocked the ability of sulindac sulfide and sulindac sulfone to inhibit beta-catenin protein expression.	sulindac sulfone	100-116	catenin beta 1	Homo sapiens	128-140	
14555707-6	2003	Treatment of human colon cancer cell lines with apoptotic concentrations of sulindac metabolites (sulindac sulfide, sulindac sulfone) induced a dose- and time-dependent inhibition of beta-catenin protein expression.	sulindac sulfone	116-132	catenin beta 1	Homo sapiens	183-195	
12392815-8	2002	A consequence of reduced beta-catenin in SW480 cells was that exisulind, CP461, and CP248 caused a concentration- and time-dependent decrease in cyclin D1 levels (EC(50) approximately 300 microM, 1 microM, and <1 microM, respectively) in 4 hr.	sulindac sulfone	84-89	catenin beta 1	Homo sapiens	25-37