PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34482605-2 2021 Our previous studies showed that BSC2 is involved in resistance to amphotericin B (AMB) through anti-oxidation in Saccharomyces cerevisiae. Amphotericin B 67-81 Bsc2p Saccharomyces cerevisiae S288C 33-37 34482605-2 2021 Our previous studies showed that BSC2 is involved in resistance to amphotericin B (AMB) through anti-oxidation in Saccharomyces cerevisiae. Amphotericin B 83-86 Bsc2p Saccharomyces cerevisiae S288C 33-37 34482605-8 2021 Although BSC2-overexpression increased the level of mannose in the cell wall, DPM1-overexpression in both BY4741 and bsc2 could confer resistance to CAS and AMB. Amphotericin B 158-161 Bsc2p Saccharomyces cerevisiae S288C 117-121 32295440-0 2020 BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae. Amphotericin B 33-36 Bsc2p Saccharomyces cerevisiae S288C 0-4 32295440-3 2020 Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive significantly to Amphotericin B. Amphotericin B 106-120 Bsc2p Saccharomyces cerevisiae S288C 70-74 32295440-4 2020 In the present study, the role of BSC2 on Amphotericin B resistance were investigated. Amphotericin B 42-56 Bsc2p Saccharomyces cerevisiae S288C 34-38 32295440-5 2020 We found that BSC2 enhanced the resistance of yeast cells to Amphotericin B, which was not related to cellular ergosterol content. Amphotericin B 61-75 Bsc2p Saccharomyces cerevisiae S288C 14-18 32295440-8 2020 Taken together, BSC2 inhibits oxidative damage induced by Amphotericin B through increasing activities of antioxidant enzymes and levels of GSH to alleviate the accumulation of reactive oxygen species, lipid peroxidation and superoxide radical, resulting in the maintenance of mitochondrial membrane potential and cell membrane integrity. Amphotericin B 58-72 Bsc2p Saccharomyces cerevisiae S288C 16-20 32295440-9 2020 However, Amphotericin B resistance mediated by BSC2 is independent of Yap1p, GSH1 and Hog1p. Amphotericin B 9-23 Bsc2p Saccharomyces cerevisiae S288C 47-51 32295440-10 2020 The results demonstrate for the first time that BSC2 enhances cell resistance to Amphotericin B by inhibiting oxidative damage in yeast. Amphotericin B 81-95 Bsc2p Saccharomyces cerevisiae S288C 48-52