PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11934664-7 2002 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR), which activates AMP-activated protein kinase (AMPK), also induced approximately twofold increases in GLUT4, MEF2A, and MEF2D in L6 myocytes. acadesine 0-45 solute carrier family 2 member 4 Rattus norvegicus 156-161 12496137-2 2003 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) can be used as a pharmacological tool to repetitively activate AMPK, and the objective of this study was to explore whether the increase in insulin-stimulated glucose uptake after either long-term exercise or chronic AICAR administration was followed by fiber-type-specific changes in insulin signaling and/or changes in GLUT-4 expression. acadesine 56-61 solute carrier family 2 member 4 Rattus norvegicus 384-390 11934664-7 2002 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR), which activates AMP-activated protein kinase (AMPK), also induced approximately twofold increases in GLUT4, MEF2A, and MEF2D in L6 myocytes. acadesine 47-52 solute carrier family 2 member 4 Rattus norvegicus 156-161 11147776-0 2001 Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. acadesine 23-77 solute carrier family 2 member 4 Rattus norvegicus 126-131 11546797-1 2001 Activation of AMP-activated protein kinase (AMPK) has been recently demonstrated to be associated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-stimulated glucose transport mediated by both GLUT1 and GLUT4 transporters. acadesine 103-148 solute carrier family 2 member 4 Rattus norvegicus 213-218 11546797-1 2001 Activation of AMP-activated protein kinase (AMPK) has been recently demonstrated to be associated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-stimulated glucose transport mediated by both GLUT1 and GLUT4 transporters. acadesine 150-155 solute carrier family 2 member 4 Rattus norvegicus 213-218 11509501-1 2001 Skeletal muscle GLUT-4 transcription in response to treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a known activator of AMP-activated protein kinase (AMPK), was studied in rats and mice. acadesine 67-121 solute carrier family 2 member 4 Rattus norvegicus 16-22 11641350-7 2001 When rats were injected with AICAR (1 mg/g body wt) for 3 days, the decline in GLUT-4 levels was prevented in denervated gastrocnemius muscles but not in denervated soleus muscles. acadesine 29-34 solute carrier family 2 member 4 Rattus norvegicus 79-85 11147776-1 2001 Recent studies have demonstrated that chronic administration of AICAR (5-aminoimidazole-4-carboxamide- 1-beta-D-ribofuranoside), an activator of the AMP-activated protein kinase, increases hexokinase activity and the contents of total GLUT4 and glycogen in rat skeletal muscles. acadesine 64-69 solute carrier family 2 member 4 Rattus norvegicus 235-240 11147776-1 2001 Recent studies have demonstrated that chronic administration of AICAR (5-aminoimidazole-4-carboxamide- 1-beta-D-ribofuranoside), an activator of the AMP-activated protein kinase, increases hexokinase activity and the contents of total GLUT4 and glycogen in rat skeletal muscles. acadesine 71-126 solute carrier family 2 member 4 Rattus norvegicus 235-240 11147776-6 2001 In conclusion, 5 days of AICAR administration induces a pronounced fiber type-specific increase in insulin-stimulated glucose uptake and GLUT4 cell surface content in rat skeletal muscle with the greatest effect observed on white fast-twitch glycolytic muscles (EPI). acadesine 25-30 solute carrier family 2 member 4 Rattus norvegicus 137-142 10444490-6 1999 Immunofluorescence studies demonstrated translocation of GLUT-4 to the myocyte sarcolemma in response to stimulation with AICAR, cyanide, or insulin. acadesine 122-127 solute carrier family 2 member 4 Rattus norvegicus 57-63 10562646-4 1999 When rats were injected with AICAR (1 mg/g body wt) for 5 days in succession and were killed 1 day after the last injection, GLUT-4 was increased by 100% in epitrochlearis muscle and by 60% in gastrocnemius muscle in response to AICAR. acadesine 29-34 solute carrier family 2 member 4 Rattus norvegicus 125-131 10444490-8 1999 In vivo infusion of AICAR caused myocardial AMPK activation and GLUT-4 translocation in the rat. acadesine 20-25 solute carrier family 2 member 4 Rattus norvegicus 64-70 10426389-3 1999 This study was designed to determine whether the increase in glucose uptake observed with AMPK activation by AICA-riboside is due to GLUT4 translocation from an intracellular location to the plasma membranes, similar to that seen in response to contraction. acadesine 109-122 solute carrier family 2 member 4 Rattus norvegicus 133-138 10426389-5 1999 Perfusion medium containing AICA-riboside was found to significantly increase AMPK activity, glucose uptake, and GLUT4 translocation in skeletal muscle above basal levels. acadesine 28-41 solute carrier family 2 member 4 Rattus norvegicus 113-118 22434076-8 2012 Whereas AMPK knockdown prevented the enhanced basal and insulin-stimulated GLUT4myc labeling by AICAR and DNP, cholesterol replenishment only blocked the AMPK-associated enhancement in insulin action. acadesine 96-101 solute carrier family 2 member 4 Rattus norvegicus 75-80 22434076-5 2012 Using L6 myotubes stably expressing an exofacial myc-epitope-tagged-GLUT4, AMPK stimulation by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR; 45 min, 1 mm) or 2,4-dinitrophenol (DNP; 30 min, 200 mum) increased cell surface GLUT4myc labeling by approximately 25% (P < 0.05). acadesine 151-156 solute carrier family 2 member 4 Rattus norvegicus 68-73 17666490-9 2007 In vivo, GLUT4 mRNA was increased 1.8-fold in the rat plantaris muscle 12 h after AICAR injection, and this induction was reduced by approximately 50% in animals cotreated with the neuronal and inducible nitric oxide synthases selective inhibitor 1-(2-trifluoromethyl-phenyl)-imidazole. acadesine 82-87 solute carrier family 2 member 4 Rattus norvegicus 9-14 18703760-2 2008 Short-term 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) administration in rats mimics exercise training on skeletal muscle in terms of increasing insulin sensitivity, mitochondrial enzymes, and GLUT4 content, but it is not known whether these adaptations are accompanied by reduced AMPK activation during subsequent exercise. acadesine 59-64 solute carrier family 2 member 4 Rattus norvegicus 204-209 17934342-9 2007 Compared with 24-month old rats, administration of the specific activator of AMPK, 5-aminoimidazole-4-carboxamide riboside (AICAR), significantly elevated AMPKalpha activity and GluT4 expression. acadesine 83-122 solute carrier family 2 member 4 Rattus norvegicus 178-183 17934342-9 2007 Compared with 24-month old rats, administration of the specific activator of AMPK, 5-aminoimidazole-4-carboxamide riboside (AICAR), significantly elevated AMPKalpha activity and GluT4 expression. acadesine 124-129 solute carrier family 2 member 4 Rattus norvegicus 178-183