PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9740689-9 1998 Two of them (12.5%) had poor response to MTX with unsatisfactory fall in serum hCG levels requiring change of chemotherapy to actinomycin D. Dactinomycin 126-139 hypertrichosis 2 (generalised, congenital) Homo sapiens 79-82 15821107-7 2005 In pituitary cells pretreated with actinomycin D, the half-life of GH mRNA was not affected by hCG but was enhanced by LH immunoneutralization. Dactinomycin 35-48 hypertrichosis 2 (generalised, congenital) Homo sapiens 95-98 7956942-10 1994 However, it did not affect the rapid induction of FS mRNA levels by hCG at 2 h. The decline in FS transcript levels in untreated and hCG-treated cells was studied by blocking the transcription with 5 microM actinomycin-D. Dactinomycin 207-220 hypertrichosis 2 (generalised, congenital) Homo sapiens 133-136 9348220-6 1997 Progesterone production was inhibited by actinomycin D in the hCG-pretreated cells, supporting the proposal that maintaining StAR protein synthesis is required for optimal steroid production in MA-10 mouse Leydig tumor cells. Dactinomycin 41-54 hypertrichosis 2 (generalised, congenital) Homo sapiens 62-65 3455047-6 1987 However, actinomycin D and cycloheximide prevented the effect of hCG. Dactinomycin 9-22 hypertrichosis 2 (generalised, congenital) Homo sapiens 65-68 8392959-10 1993 The addition of cycloheximide or actinomycin D to the media did not affect the basal production of estradiol but completely blocked the bGH and hCG stimulation of the aromatization of exogenous testosterone to estradiol. Dactinomycin 33-46 hypertrichosis 2 (generalised, congenital) Homo sapiens 144-147 3007125-11 1986 Cycloheximide and actinomycin D inhibit hCG-mediated and 8-BrcAMP-mediated down-regulation. Dactinomycin 18-31 hypertrichosis 2 (generalised, congenital) Homo sapiens 40-43 32141676-9 2020 Level of hCG pre-dactinomycin remained a significant risk-factor in multivariate analysis (OR 2.93(95% CI 1.02 - 8.40) p=0.045. Dactinomycin 17-29 hypertrichosis 2 (generalised, congenital) Homo sapiens 9-12 6198267-5 1983 Addition of cycloheximide or Actinomycin D inhibited protein synthesis and RNA synthesis, respectively, and prevented the stimulation of hCG by sodium butyrate. Dactinomycin 29-42 hypertrichosis 2 (generalised, congenital) Homo sapiens 137-140 6196179-4 1983 Actinomycin D pretreatment prevented the hCG-induced decrease of C-17-C-20 lyase activity. Dactinomycin 0-13 hypertrichosis 2 (generalised, congenital) Homo sapiens 41-44 32141676-14 2020 Chance of curative treatment with dactinomycin is strongly related to the hCG level. Dactinomycin 34-46 hypertrichosis 2 (generalised, congenital) Homo sapiens 74-77 32223011-0 2020 A switch to dactinomycin: What is the cutoff value for hCG? Dactinomycin 12-24 hypertrichosis 2 (generalised, congenital) Homo sapiens 55-58 22740971-6 2012 Following 2 cycles of combinative chemotherapy consisting of fluorouracil (5-FU) and dactinomycin (KSM), hCG concentrations decreased to normal levels. Dactinomycin 85-97 hypertrichosis 2 (generalised, congenital) Homo sapiens 105-108 26137037-10 2015 The lesion disappeared following five cycles of methotrexate+ etoposide+actinomycin D therapy, which was performed as postoperative chemotherapy, and the patient"s serum hCG level decreased to below the detection limit. Dactinomycin 72-85 hypertrichosis 2 (generalised, congenital) Homo sapiens 170-173 21051988-8 2010 The risk of failure with pulse dactinomycin was higher for serum hCG levels 10 or higher when initiating pulse dactinomycin (odds ratio, 8.91; 95% confidence interval, 1.08-73.53) and a rising World Health Organization score of 2 or higher after first-line chemotherapy (odds ratio, 12.59; 95% confidence interval, 1.60-99.25). Dactinomycin 31-43 hypertrichosis 2 (generalised, congenital) Homo sapiens 65-68 21051988-8 2010 The risk of failure with pulse dactinomycin was higher for serum hCG levels 10 or higher when initiating pulse dactinomycin (odds ratio, 8.91; 95% confidence interval, 1.08-73.53) and a rising World Health Organization score of 2 or higher after first-line chemotherapy (odds ratio, 12.59; 95% confidence interval, 1.60-99.25). Dactinomycin 111-123 hypertrichosis 2 (generalised, congenital) Homo sapiens 65-68 19135660-8 2009 The patient"s serum hCG level declined to a normal range after two administrations of dactinomycin. Dactinomycin 86-98 hypertrichosis 2 (generalised, congenital) Homo sapiens 20-23 19135660-9 2009 CONCLUSION(S): Dactinomycin could be an alternative in cases for which MTX is not effective and persistently high hCG levels exist. Dactinomycin 15-27 hypertrichosis 2 (generalised, congenital) Homo sapiens 114-117