PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7896537-2	1994	Among 8 compounds tested at nontoxic concentrations, flupentixol, a piperazine-substituted thioxanthene, was the most potent in enhancing the cytotoxicity of anticancer drugs commonly associated with the multidrug resistant (MDR) phenotype, such as Adriamycin, actinomycin D, vinblastine, and vincristine, but not 5-fluorouracil, a drug usually unaffected by MDR.	Dactinomycin	261-274	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	225-228	
7909724-2	1994	The hybrid cells expressed multidrug resistance (MDR), i.e., resistance to VCR and cross-resistance to Adriamycin (ADM) and actinomycin D (Act.	Dactinomycin	124-137	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	49-52	
23063411-0	2013	Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.	Dactinomycin	104-117	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	33-38	
23063411-7	2013	Lower intracellular accumulation of actinomycin D was observed in MDCKII-ABCB1 cells as compared to MDCKII-WT (0.98 nM vs. 0.1 nM, p<0.0001), which was reversed upon ABCB1 inhibition.	Dactinomycin	36-49	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	73-78	
23063411-7	2013	Lower intracellular accumulation of actinomycin D was observed in MDCKII-ABCB1 cells as compared to MDCKII-WT (0.98 nM vs. 0.1 nM, p<0.0001), which was reversed upon ABCB1 inhibition.	Dactinomycin	36-49	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	169-174	
23063411-9	2013	Actinomycin D efflux over 2 h was most pronounced in MDCKII-ABCB1 cells, with 5.5-fold lower intracellular levels compared to WT.	Dactinomycin	0-13	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	60-65	
23063411-12	2013	Results confirm actinomycin D as a substrate for ABCB1, ABCC1 and ABCC2, and indicate that Abcb1a/1b and Abcc2 can influence the in vivo disposition of actinomycin D.	Dactinomycin	16-29	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	49-54	
22024132-10	2012	However, studies with actinomycin D revealed that the half-life of Mdr1a and Mdr1b mRNA were significantly prolonged by two-fold in ivermectin-treated cells suggesting a post-transcriptional mode of ivermectin regulation.	Dactinomycin	22-35	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	77-82