PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2516117-5 1989 The longest time-period for the concentration of tobramycin at the base of a biofilm 100 micron deep to rise to 90% of the concentration outside the biofilm was predicted to be 2.4 h. For cefsulodin penetration, irreversible hydrolysis catalysed by beta-lactamase was taken into account, using beta-lactamase levels taken from the literature. Tobramycin 49-59 Beta lactamase Pseudomonas aeruginosa 249-263 2516117-5 1989 The longest time-period for the concentration of tobramycin at the base of a biofilm 100 micron deep to rise to 90% of the concentration outside the biofilm was predicted to be 2.4 h. For cefsulodin penetration, irreversible hydrolysis catalysed by beta-lactamase was taken into account, using beta-lactamase levels taken from the literature. Tobramycin 49-59 Beta lactamase Pseudomonas aeruginosa 294-308 18644957-3 2008 The bla(VIM-13)-producing isolate showed resistance to all beta-lactams (except aztreonam), gentamicin, tobramycin, and ciprofloxacin. Tobramycin 104-114 Beta lactamase Pseudomonas aeruginosa 4-7