PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16600452-6	2006	The concentrations of perospirone and ID-15036 were influenced significantly by the treatment with carbamazepine, and this was probably attributable to the induction of CYP3A4.	perospirone	22-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-175	
18006133-1	2008	Perospirone, a serotonin 5-HT2A and dopamine D2 receptor antagonist, is metabolized to ID-15036 by CYP3A4 and the elimination half-life (T1/2) for the latter is longer than the former.	perospirone	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105	
16600452-2	2006	It has been shown that perospirone is metabolized to ID-15036 mainly by CYP3A4 based on an in vitro study.	perospirone	23-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78	
16600452-7	2006	This study provided an in vivo evidence of involvement of CYP3A4 in the metabolism of perospirone.	perospirone	86-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64	
15619261-1	2005	In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver microsomes and expressed P450 isoforms.	perospirone	119-130	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97	
15619261-6	2005	These results indicated that the metabolism of perospirone in human liver was mainly catalysed by CYP3A4, and to a lesser extent CYP2C8 and CYP2D6 were responsible because kinetic data (K(m) and V(max)) of CYP2C8 and CYP2D6 suggested catalytic potential.	perospirone	47-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104	
16418697-2	2006	Based on an in vitro study, it is reported that perospirone is mainly metabolized to ID-15036 by cytochrome P450 (CYP) 3A4.	perospirone	48-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	97-122	
16418697-3	2006	In this study, the authors investigated the effects of itraconazole, which is a specific inhibitor of CYP3A4, or tandospirone, which is mainly metabolized by CYP3A4 and is expected to competitively inhibit the activity of this enzyme, on single oral dose pharmacokinetics of perospirone.	perospirone	275-286	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	158-164	
16418697-7	2006	The present study suggests that CYP3A4 is significantly involved in metabolism of perospirone in humans.	perospirone	82-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38	
14503667-5	2003	On the other hand, the perospirone metabolism was markedly reduced by ketoconazole indicating a major role for CYP 3A4.	perospirone	23-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-118