PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30559731-0	2018	Transcriptional Landscape of a bla KPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10.	Imipenem	65-73	beta-lactamase	Escherichia coli	31-34	
30559731-3	2018	Using E. coli TOP10 strain harboring a multi-replicon IncFIIK-IncFIB bla KPC-2-gene carrying plasmid pBIC1a from K. pneumoniae ST-258 clinical isolate BIC-1, we aimed to identify basal gene expression and the effects of imipenem exposure using whole transcriptome approach by RNA sequencing (RNA-Seq).	Imipenem	220-228	beta-lactamase	Escherichia coli	69-72	
29776449-2	2018	In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described.	Imipenem	105-113	beta-lactamase	Escherichia coli	50-53	
29776449-2	2018	In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described.	Imipenem	105-113	beta-lactamase	Escherichia coli	62-65	
29776449-6	2018	PCR was also carried out to determine the presence of bla IMP and bla VIM genes in imipenem-resistant isolates.	Imipenem	83-91	beta-lactamase	Escherichia coli	54-57	
29776449-6	2018	PCR was also carried out to determine the presence of bla IMP and bla VIM genes in imipenem-resistant isolates.	Imipenem	83-91	beta-lactamase	Escherichia coli	66-69	
24132992-8	2014	Bla(Mab) hydrolysed imipenem more efficiently (k(cat)/K(m) = 3.0 x 10(4) M(-1) s(-1)), indicating that the in vivo activity of this drug might be improved by combination with a beta-lactamase inhibitor.	Imipenem	20-28	beta-lactamase	Escherichia coli	0-3	
21153909-6	2011	Susceptibility testing performed on recombinant strains carrying the bla(KPC-3) gene with or without the insertion revealed that minimum inhibitory concentrations of imipenem, meropenem, cefepime, and cefotaxime for E. coli EMU-KPC3 (without insertion) were four times higher than that of E. coli EKPC3 (with insertion).	Imipenem	166-174	beta-lactamase	Escherichia coli	69-72	
19141739-6	2009	Due to the acquisition of bla(IMP-1), the susceptibility of E. coli transconjugants to imipenem, meropenem, panipenem and biapenem decreased by 32-, 256-, 64- and 128-fold, respectively.	Imipenem	87-95	beta-lactamase	Escherichia coli	26-29	
19141739-8	2009	Strains harbouring bla(IMP-10) showed higher-level resistance to imipenem, meropenem and panipenem than the strains harbouring bla(IMP-1), although the nucleotide sequences of the class 1 integrons carrying bla(IMP-10) and bla(IMP-1) were identical except for a single point mutation.	Imipenem	65-73	beta-lactamase	Escherichia coli	19-22	
18184647-6	2008	RESULTS: The 24 isolates with positive EDTA/imipenem synergy tests had bla(VIM-1) carried on 40-150 kb plasmids.	Imipenem	44-52	beta-lactamase	Escherichia coli	71-74	
18222954-7	2008	RESULTS: In 30 bla(VIM)-positive isolates that exhibited MICs of imipenem < or = 4 mg/L, MBL Etest could not be evaluated.	Imipenem	65-73	beta-lactamase	Escherichia coli	15-18	
11257029-8	2001	The gene, bla(KPC-1), was cloned in E. coli and shown to confer resistance to imipenem, meropenem, extended-spectrum cephalosporins, and aztreonam.	Imipenem	78-86	beta-lactamase	Escherichia coli	10-13