PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19022936-2	2009	The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1).	oseltamivir carboxylate	55-78	carboxylesterase 1	Homo sapiens	124-142	
22588607-1	2012	Bioactivation of the antiviral agent oseltamivir to active oseltamivir carboxylate is catalyzed by carboxylesterase 1 (CES1).	oseltamivir carboxylate	59-82	carboxylesterase 1	Homo sapiens	99-117	
22588607-1	2012	Bioactivation of the antiviral agent oseltamivir to active oseltamivir carboxylate is catalyzed by carboxylesterase 1 (CES1).	oseltamivir carboxylate	59-82	carboxylesterase 1	Homo sapiens	119-123	
28331290-2	2017	It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1) to its active form, oseltamivir carboxylate.	oseltamivir carboxylate	111-134	carboxylesterase 1	Homo sapiens	65-83	
28331290-2	2017	It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1) to its active form, oseltamivir carboxylate.	oseltamivir carboxylate	111-134	carboxylesterase 1	Homo sapiens	85-89	
27228223-1	2016	Oseltamivir, an inactive anti-influenza virus prodrug, is activated (hydrolysed) in vivo by carboxylesterase 1 (CES1) to its active metabolite oseltamivir carboxylate.	oseltamivir carboxylate	143-166	carboxylesterase 1	Homo sapiens	92-110	
27228223-1	2016	Oseltamivir, an inactive anti-influenza virus prodrug, is activated (hydrolysed) in vivo by carboxylesterase 1 (CES1) to its active metabolite oseltamivir carboxylate.	oseltamivir carboxylate	143-166	carboxylesterase 1	Homo sapiens	112-116	
25103325-5	2014	METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity.	oseltamivir carboxylate	123-146	carboxylesterase 1	Homo sapiens	156-160	
25103325-5	2014	METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity.	oseltamivir carboxylate	123-146	carboxylesterase 1	Homo sapiens	190-194	
25103325-5	2014	METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity.	oseltamivir carboxylate	148-151	carboxylesterase 1	Homo sapiens	156-160	
25103325-5	2014	METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity.	oseltamivir carboxylate	148-151	carboxylesterase 1	Homo sapiens	190-194	
25103325-7	2014	Then the changes in oseltamivir and OSC exposure in humans with CES1 impaired by ethanol or polymorphisms were simulated using a PBPK model incorporating in vitro inhibition and enzyme kinetic data.	oseltamivir carboxylate	36-39	carboxylesterase 1	Homo sapiens	64-68	
25103325-10	2014	RESULTS: The simulated changes in oseltamivir and OSC exposures in humans with CES1 impaired by ethanol or polymorphism were similar to the observed data.	oseltamivir carboxylate	50-53	carboxylesterase 1	Homo sapiens	79-83	
19022936-2	2009	The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1).	oseltamivir carboxylate	55-78	carboxylesterase 1	Homo sapiens	144-148	
19022936-6	2009	In vitro incubation studies demonstrated that the S9 fractions prepared from the cells transfected with WT CES1 and human liver tissues rapidly convert oseltamivir to oseltamivir carboxylate.	oseltamivir carboxylate	167-190	carboxylesterase 1	Homo sapiens	107-111