PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 34-38 parathyroid hormone Homo sapiens 13-32 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 138-142 parathyroid hormone Homo sapiens 13-32 22393015-2 2012 However, it is unknown whether iPTH induces Wnt10b production and bone anabolism through direct activation of the parathyroid hormone (PTH)/PTH-related protein receptor (PPR) in T cells. ipth 31-35 parathyroid hormone Homo sapiens 114-133 20089790-1 2010 The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. ipth 127-131 parathyroid hormone Homo sapiens 106-125 21427530-5 2012 RESULTS: An improvement of the typical clinical symptoms was found in every patient undergoing surgery, and a significant reduction in intact PTH (iPTH) serum levels was achieved. ipth 147-151 parathyroid hormone Homo sapiens 142-145 17891053-1 2007 OBJECTIVES: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism. ipth 91-95 parathyroid hormone Homo sapiens 63-82 18520104-2 2008 The aim of this prospective trial was to evaluate the acute and chronic effects of TPTD in endogenous intact PTH (iPTH) levels in postmenopausal women with established osteoporosis. ipth 114-118 parathyroid hormone Homo sapiens 109-112 17002574-10 2006 In multiple stepwise linear regression analysis, levels of 25-hydroxyvitamin D correlated positively and intact PTH (iPTH) correlated negatively to Z scores at the lumbar spine and wrist. ipth 117-121 parathyroid hormone Homo sapiens 112-115 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 41-44 16425080-3 2006 Here we evaluate the addition of a rapid intraoperative parathyroid hormone (iPTH) assay for patients undergoing MIRP. ipth 77-81 parathyroid hormone Homo sapiens 56-75 16785355-7 2006 The algorithm for this group of patients specified that they should receive an injection with technetium Tc 99m sestamibi prior to parathyroidectomy and that an intraoperative parathyroid hormone (iPTH) level decrease of more than 50% be used to define intraoperative success. ipth 197-201 parathyroid hormone Homo sapiens 176-195 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 96-99 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 96-99 15828900-10 2005 Serum intact PTH (iPTH) significantly increased in patients with a low or normal iPTH level (< or =300 pg/mL), while it did not change in patients with secondary hyperparathyroidism (>300 pg/mL). ipth 18-22 parathyroid hormone Homo sapiens 13-16 15828900-10 2005 Serum intact PTH (iPTH) significantly increased in patients with a low or normal iPTH level (< or =300 pg/mL), while it did not change in patients with secondary hyperparathyroidism (>300 pg/mL). ipth 81-85 parathyroid hormone Homo sapiens 13-16 14507273-6 2003 RESULTS: Oral Ca induced dose-sensitive changes in parathyroid hormone (iPTH), total (tCa), and ionized (iCa) calcium levels. ipth 72-76 parathyroid hormone Homo sapiens 51-70 12552245-5 2003 The experimental subjects were divided into two subgroups, based on the blood level of intact PTH (iPTH). ipth 99-103 parathyroid hormone Homo sapiens 94-97 9612524-1 1998 BACKGROUND: Others have reported a clear distinction between patients with primary hyperparathyroidism (PHPT) and normal subjects using the intact PTH (iPTH) assay. ipth 152-156 parathyroid hormone Homo sapiens 147-150 15775259-1 2002 Most commercial intact PTH (iPTH) assays cross-react with PTH7-84 and the proportional levels of PTH7-84 in patients are variable in a much wider range in samples obtained from hyperparathyroid patients. ipth 28-32 parathyroid hormone Homo sapiens 23-26 12131092-3 2002 Recently the authors have found that most commercial intact PTH (iPTH) assays cross-react with non-(1-84) PTH (likely 7-84 PTH) and that the proportional levels of non-(1-84) PTH in patients were variable in a much wider range, accounting mostly for 20% to 60% of the immunoreactivity in samples obtained from hyperparathyroid patients. ipth 65-69 parathyroid hormone Homo sapiens 60-63 11084846-10 2000 It is therefore necessary to exclude the presence of hyperparathyroidism with ionised calcium and, in cases of high values, intact PTH (iPTH), before performing a histological diagnosis of a large cell bone tumor. ipth 136-140 parathyroid hormone Homo sapiens 131-134 8345045-1 1993 Calcium infusion in normal men decreases immunoreactive PTH (iPTH). ipth 61-65 parathyroid hormone Homo sapiens 56-59 8154313-7 1994 Serum immunoreactive PTH (iPTH) rose to twice pretreatment values (86 +/- 11 pM, mean +/- SEM; reference range for iPTH, > 50 years, < 50 pM; < 50 years, < 40 pM), returning to normal 4-8 weeks after therapy. ipth 26-30 parathyroid hormone Homo sapiens 21-24 8408450-8 1993 Serum osteocalcin increased by 35.7 +/- 17.3% (P < 0.05), serum immunoreactive PTH (iPTH) increased by 41.4 +/- 15.1% (P < 0.05), serum calcium decreased by 2.3 +/- 1.0% (P < 0.05), and serum albumin decreased by 4.5 +/- 1.7% (P < 0.05). ipth 87-91 parathyroid hormone Homo sapiens 82-85 2335575-1 1990 In an earlier 8-day study, we showed increased immunoreactive PTH (iPTH) levels in young adults fed high phosphorus (P), low calcium (Ca) diets assembled from common grocery foods, a dietary pattern characteristic of teens and young adults. ipth 67-71 parathyroid hormone Homo sapiens 62-65 1425424-1 1992 The plasma concentration of immunoreactive PTH (iPTH) increases with postmaturational aging in both humans and animals. ipth 48-52 parathyroid hormone Homo sapiens 43-46 1865080-5 1991 PTH levels should be helpful in defining coexisting hyperparathyroidism in patients with thyrotoxicosis since in the latter iPTH is usually suppressed. ipth 124-128 parathyroid hormone Homo sapiens 0-3 1986021-2 1991 The immunoreactive PTH (iPTH) level determined by RIA using antiserum specific for the C-terminal region of PTH-(65-69) was in the upper normal range (0.6 ng/mL) and over the next 7 yr increased gradually to 6 ng/mL. ipth 24-28 parathyroid hormone Homo sapiens 19-22 2017266-9 1991 We conclude that I-PTH assay has been shown to capture acute changes in parathyroid gland activity in hemodialyzed patients for both low and high iPTH levels. ipth 146-150 parathyroid hormone Homo sapiens 19-22 34595186-13 2021 Prospective studies are warranted to explore further model applications, such as patient-level prediction of iPTH response to PTH-lowering treatment. ipth 109-113 parathyroid hormone Homo sapiens 126-129 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 10-13 3496351-4 1987 Serum immunoreactive PTH (iPTH) levels were significantly higher during pregnancy than in nonpregnant women [97 +/- 5 vs. 56 +/- 4 ng/L (mean +/- SE); P less than 0.001]. ipth 26-30 parathyroid hormone Homo sapiens 21-24 3595732-3 1987 With the C-RIA 12 patients including the 2 patients not discriminated by the M-RIA had immunoreactive PTH (iPTH) values within the normal range of this assay (normal range: undetectable to 88.6 pmol/l). ipth 107-111 parathyroid hormone Homo sapiens 102-105 3595732-7 1987 Hyperparathyroid sera not discriminated by the C-RIA but with elevated iPTH in the M-RIA showed decreased amounts of midregion-C-terminal PTH fragments, while intact PTH comprised the highest amount of total circulating PTH immunoreactivity in the M-RIA. ipth 71-75 parathyroid hormone Homo sapiens 138-141 3595732-7 1987 Hyperparathyroid sera not discriminated by the C-RIA but with elevated iPTH in the M-RIA showed decreased amounts of midregion-C-terminal PTH fragments, while intact PTH comprised the highest amount of total circulating PTH immunoreactivity in the M-RIA. ipth 71-75 parathyroid hormone Homo sapiens 138-141 3787459-1 1986 The clinical value of measuring serum immunoreactive parathyroid hormone (iPTH) for the diagnosis of primary hyperparathyroidism is sometimes debated, and the clinical significance of an elevated postoperative serum iPTH level is unknown. ipth 74-78 parathyroid hormone Homo sapiens 53-72 2821053-2 1987 Serum immunoreactive PTH (iPTH) was measured with two well characterized antisera; an amino (N)-terminal antiserum which cross-reacts with the biologically active domain (1-34) and recognizes intact hormone, and a midregion (44-68) antiserum which cross-reacts with intact hormone and biologically inactive midregion/C-terminal fragments. ipth 26-30 parathyroid hormone Homo sapiens 21-24 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 56-59 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 56-59 6319444-2 1984 Serum immunoreactive PTH (iPTH) was measured with a goat antiserum developed against human PTH, using (43Tyr) human PTH-(44-68) as tracer and standards. ipth 26-30 parathyroid hormone Homo sapiens 21-24 3972336-1 1985 In order to shed light on the discrepant changes in plasma immunoreactive parathyroid hormone (iPTH) during hemodialysis (HD) and ultrafiltration (UF) in end-stage renal failure, the influence of filtration of PTH fragments on the iPTH level in plasma was examined in 2 sets of experiments: in vitro dialysis of 125I-bPTH 1-84, 125I-hPTH 1-34 and 125I-hPTH 53-84 added to plasma was successively performed through a cuprophane membrane. ipth 95-99 parathyroid hormone Homo sapiens 74-93 2993339-1 1985 Previous studies suggested that estrogen administration leads to an increase in circulating immunoreactive PTH (iPTH), thought to be secondary to a slight decrease in serum calcium resulting from inhibition of bone resorption. ipth 112-116 parathyroid hormone Homo sapiens 107-110 6822652-1 1983 Purified secretin infused in an estimated physiological dose caused an increase in serum immunoreactive PTH (iPTH) and calcitonin (iCT) in man. ipth 109-113 parathyroid hormone Homo sapiens 104-107 6723731-4 1984 The major part of immunoreactive PTH (iPTH; on the average above 50%) eluted corresponding to fragments with a molecular size about 7,500 daltons in both radioimmunoassays. ipth 38-42 parathyroid hormone Homo sapiens 33-36 7451639-2 1981 In vitro, histamine (10(-5)-10(-7) M) caused a dose-related significant stimulation of immunoreactive PTH (iPTH) secretion; this was blocked by the simultaneous addition of cimetidine (10(-5) M). ipth 107-111 parathyroid hormone Homo sapiens 102-105 6867614-1 1983 Serum immunoreactive PTH (iPTH) was measured in 74 patients with urolithiasis and correlated to the corresponding serum calcium values. ipth 26-30 parathyroid hormone Homo sapiens 21-24 7179613-3 1982 The carboxyl-terminal immunoreactive PTH (iPTH) values in these patients were 16 +/- 5 ngeq/ml (M +/- SD), no higher than the iPTH values in the other groups, e.g. normocalciuric patients had an iPTH of 23 +/- 8 ngeq/ml. ipth 42-46 parathyroid hormone Homo sapiens 37-40 7438468-5 1980 Mean plasma immunoreactive PTH (iPTH) levels increased significantly (P < 0.05) from 521 +/- 41 before to 696 +/- 96 ng/l after oestrogen treatment. ipth 32-36 parathyroid hormone Homo sapiens 27-30 737558-3 1978 There was also a significant correlation of Fa47Ca with the serum phosphate (SeP) level and of immunoreactive parathyroid hormone (iPTH) with renal function. ipth 131-135 parathyroid hormone Homo sapiens 110-129 182417-11 1976 The rapidity with which serum IPTH rose in response to magnesium therapy indicates that this may reflect a defect in parathyroid hormone (PTH) secretion rather than its biosynthesis. ipth 30-34 parathyroid hormone Homo sapiens 117-136 4338118-6 1972 Serum immunoreactive parathyroid hormone (IPTH) increased significantly after estrogen therapy; the change in IPTH was inversely related to the change in serum calcium (P < 0.001, sign test). ipth 42-46 parathyroid hormone Homo sapiens 21-40 4330004-3 1971 A second anti-PTH antiserum also differentiated between IPTH in the two groups, although IPTH was undetectable in only 1 of 14 sera. ipth 56-60 parathyroid hormone Homo sapiens 14-17 5543877-6 1971 Induced episodes of hypercalcemia and hypocalcemia resulted in appropriate responses in serum immunoreactive PTH (IPTH) in normal subjects and in patients with Paget"s disease of bone. ipth 114-118 parathyroid hormone Homo sapiens 109-112 27192696-2 2016 OBJECTIVE: To assess: 1) the effects of D2 vs D3 on serum total and free 25D; and 2) whether change in intact PTH (iPTH) is more strongly associated with change in total vs free 25D. ipth 115-119 parathyroid hormone Homo sapiens 110-113 28243964-9 2017 In multivariate analysis, serum intact PTH (iPTH) was correlated with mean normal-to-normal R-R intervals, mean heart rate, and VLF, serum calcium was correlated with standard deviation of 5-min average of normal R-R intervals (SDANN), and serum phosphorus was correlated with VLF and LF/HF. ipth 44-48 parathyroid hormone Homo sapiens 39-42 27867867-0 2016 Early intact PTH (iPTH) is an early predictor of postoperative hypocalcemia for a safer and earlier hospital discharge: an analysis on 260 total thyroidectomies. ipth 18-22 parathyroid hormone Homo sapiens 13-16 27867867-3 2016 Early intact PTH (iPTH) has been proposed as early predictor of postoperative hypocalcemia. ipth 18-22 parathyroid hormone Homo sapiens 13-16 24937533-5 2014 We investigated their serum Mg levels and the correlation between intact PTH (iPTH) and the serum Mg levels and other clinical parameters and medications. ipth 78-82 parathyroid hormone Homo sapiens 73-76 27438973-7 2016 RESULTS: Among controls, hypocalcemia elicited a major rise in intact PTH (iPTH) levels 4 minutes after bicarbonate infusion. ipth 75-79 parathyroid hormone Homo sapiens 70-73 23814412-5 2013 Compared to the controls, CKD subjects showed elevated intact PTH (iPTH), BAP, and tDPD and lower BMD. ipth 67-71 parathyroid hormone Homo sapiens 62-65 24483159-1 2014 OBJECTIVE: Our goal was to compare direct quantitation of circulating free 25-hydroxyvitamin D (25(OH)D)levels to calculated free 25(OH)D levels and their relationships to intact PTH (iPTH), a biomarker of 25(OH)D effect, in humans with a range of clinical conditions. ipth 184-188 parathyroid hormone Homo sapiens 179-182