PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31888596-7	2019	The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3.	Zinc Oxide	46-49	interleukin 6	Homo sapiens	144-157	
32570911-6	2020	RESULTS: Our data showed that ZnO was able to reduce the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation.	Zinc Oxide	30-33	interleukin 6	Homo sapiens	164-168	
31888596-7	2019	The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3.	Zinc Oxide	46-49	interleukin 6	Homo sapiens	159-163	
29028602-5	2017	In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a significant effect on epithelial permeability rate.	Zinc Oxide	38-41	interleukin 6	Homo sapiens	96-109	
31017309-6	2019	Ap and Bl exposure to 100 mug/mL sono ZnO NPs and Ap exposure to 50 mug/mL commercial ZnO NPs induced a significant (P < 0.05) release of interleukin-6.	Zinc Oxide	86-89	interleukin 6	Homo sapiens	141-154	
29028602-5	2017	In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a significant effect on epithelial permeability rate.	Zinc Oxide	38-41	interleukin 6	Homo sapiens	111-115	
29028602-6	2017	Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone.	Zinc Oxide	63-66	interleukin 6	Homo sapiens	131-144	
29028602-6	2017	Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone.	Zinc Oxide	63-66	interleukin 6	Homo sapiens	146-150	
28441756-6	2017	Paradoxically, the release of inflammatory cytokine interleukin-6 (IL-6) was decreased, which indicated the anti-inflammatory effects of ZnO NPs when BSA was present.	Zinc Oxide	137-140	interleukin 6	Homo sapiens	52-65	
28441756-6	2017	Paradoxically, the release of inflammatory cytokine interleukin-6 (IL-6) was decreased, which indicated the anti-inflammatory effects of ZnO NPs when BSA was present.	Zinc Oxide	137-140	interleukin 6	Homo sapiens	67-71	
18502114-0	2008	An interleukin-6 ZnO/SiO(2)/Si surface acoustic wave biosensor.	Zinc Oxide	17-20	interleukin 6	Homo sapiens	3-16	
24555677-7	2014	Exposure of THP-1 cells to both sizes of ZnO stimulated and increased release of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6, as well as chemokine IL-8, and upregulated the expression of monocyte chemoattractant protein-1 and cyclooxygenase-2 genes.	Zinc Oxide	41-44	interleukin 6	Homo sapiens	170-174	
27278808-15	2016	CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6.	Zinc Oxide	35-38	interleukin 6	Homo sapiens	176-180	
18502114-1	2008	A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported.	Zinc Oxide	25-28	interleukin 6	Homo sapiens	108-121	
18502114-1	2008	A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported.	Zinc Oxide	25-28	interleukin 6	Homo sapiens	123-127	
18502114-2	2008	The biosensors operating at 747.7 MHz and 1.586 GHz were functionalized by immobilizing the monoclonal IL-6 antibody onto the ZnO biosensor surface both through direct surface adsorption and through covalent binding on gluteraldehyde.	Zinc Oxide	126-129	interleukin 6	Homo sapiens	103-107	
16581242-0	2006	Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications.	Zinc Oxide	62-65	interleukin 6	Homo sapiens	40-53	
16581242-2	2006	Interleukin-6 was immobilized in the range of 0.276-10 pg/ml on the surface of ZnO and SiO(2), and visualized at each stage, while protein-protein interactions were measured with the antigen/antibody immunoassay of solid-phase ELISA, which we modified for these types of substrates.	Zinc Oxide	79-82	interleukin 6	Homo sapiens	0-13	
11094787-8	2000	The increase in IL-6 levels observed in the clinically responsive, and to a lesser extent, tolerant, states following zinc oxide inhalation is consistent with the dual role of IL-6 as a pyrogen and anti-inflammatory agent.	Zinc Oxide	118-128	interleukin 6	Homo sapiens	16-20	
16123706-9	2005	Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation.	Zinc Oxide	103-113	interleukin 6	Homo sapiens	34-38	
11094787-8	2000	The increase in IL-6 levels observed in the clinically responsive, and to a lesser extent, tolerant, states following zinc oxide inhalation is consistent with the dual role of IL-6 as a pyrogen and anti-inflammatory agent.	Zinc Oxide	118-128	interleukin 6	Homo sapiens	176-180	
34590104-0	2021	Photoelectrochemical immunoassay of interleukin-6 based on covalent reaction-triggered photocurrent polarity switching of ZnO@fullerenol.	Zinc Oxide	122-125	interleukin 6	Homo sapiens	36-49	
9273875-0	1997	Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value.	Zinc Oxide	106-116	interleukin 6	Homo sapiens	58-62	
9273875-7	1997	In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m3 zinc oxide.	Zinc Oxide	127-137	interleukin 6	Homo sapiens	40-53	
9273875-7	1997	In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m3 zinc oxide.	Zinc Oxide	127-137	interleukin 6	Homo sapiens	55-59	
9273875-12	1997	Inhalation of zinc oxide for 2 hours at the current TLV of 5 mg/m3 produces fever and symptoms along with elevation in plasma IL-6 levels.	Zinc Oxide	14-24	interleukin 6	Homo sapiens	126-130	
9356189-7	1997	Zinc oxide exposure was a statistically significant, dose-dependent predictor of increases in BAL TNF (mean exposure-sham difference +/- SE = 9.5 +/- 3.6 pg/mL, P = 0.02), IL-6 (mean exposure-sham difference +/- SE = 5.5 +/- 1.8 pg/mL, P = 0.009), and IL-8 (mean exposure-sham difference +/- SE = 64.1 +/- 23.9 pg/mL, P = 0.02).	Zinc Oxide	0-10	interleukin 6	Homo sapiens	172-176	
34590104-2	2021	The sensitive detection of interleukin-6 is achieved by using CA-encapsulated liposome as the label and COH-coated ZnO as the photoactive material, with a detection limit of 1.0 fg mL-1.	Zinc Oxide	115-118	interleukin 6	Homo sapiens	27-40	
34257799-14	2021	The concentrations of IL-1beta, IL-6, and IL-8 in the plasma were all decreased upon ZnO administration.	Zinc Oxide	85-88	interleukin 6	Homo sapiens	32-36