PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34356864-2	2021	IDH enzymes catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG), an intermediate in the citric acid cycle.	Citric Acid	108-119	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3	
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	284-290	
31564968-2	2019	Preclinical studies have demonstrated a mutated enzyme in the citric acid cycle, isocitrate dehydrogenase (IDH), leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG).	Citric Acid	62-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	81-105	
31564968-2	2019	Preclinical studies have demonstrated a mutated enzyme in the citric acid cycle, isocitrate dehydrogenase (IDH), leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG).	Citric Acid	62-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110	
31068457-1	2019	Mutations of the isocitrate dehydrogenase genes IDH1 and IDH2, key enzymes involved in citrate metabolism, are important oncogenic events in several cancer types, including in 1%-3% of all prostate cancer cases.	Citric Acid	20-27	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52	
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	101-125	
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	127-130	
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	133-137	
27125548-1	2016	Adaptation to anchorage-independent growth requires IDH1-mediated changes in citrate metabolism.	Citric Acid	77-84	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	52-56	
22080945-5	2012	RECENT FINDINGS: Metabolomic studies of IDH1/2 mutant cells have revealed alterations in glutamine, fatty acid, and citrate synthesis pathways.	Citric Acid	116-123	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	40-44	
27049945-13	2016	Together, the data indicate that adaptation to anchorage independence requires a fundamental change in citrate metabolism, initiated by IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.	Citric Acid	103-110	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	136-140	
23876293-2	2013	IDH3 is mitochondrial, uses NAD(H) and was believed to be the IDH that supports the citric acid cycle.	Citric Acid	84-95	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3	
23876293-5	2013	Cellular levels of citrate, alpha-ketoglutarate, malate and ATP were altered in patterns consistent with blockage at the mitochondrial IDH reactions.	Citric Acid	19-26	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	135-138	
23504317-2	2013	In addition, reductive carboxylation of alpha-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) was recently shown to be a major source of citrate synthesis from glutamine.	Citric Acid	66-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	91-95	
24755473-0	2014	IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.	Citric Acid	21-32	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4	
24857658-2	2014	In contrast, hypoxia and other impairments of mitochondrial function induce an alternative pathway that produces citrate by reductively carboxylating alpha-ketoglutarate (AKG) via NADPH-dependent isocitrate dehydrogenase (IDH).	Citric Acid	113-120	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	222-225	
23456655-7	2013	The CSF levels of the citric, isocitric, and lactic acids were significantly higher in grade I-III gliomas with mutant IDH than in those with wild-type IDH.	Citric Acid	22-28	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	119-122	
19246647-1	2009	IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas.	Citric Acid	67-78	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4