PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33220427-9 2021 Chronic administration of rotenone caused PD-related pathological processes like oxidative stress, and produced a significant decrease in tyrosine hydroxylase (TH), DA transporter (DAT), Vesicular monoamine transporter 2 (VMAT2), and a significant upregulated in alpha-synuclein and apoptotic protein expression of Bax, Cyt-C and caspases -3, -8 and -9 as well as by decreasing Bcl2 expression. Rotenone 26-34 BCL2 associated X, apoptosis regulator Rattus norvegicus 315-318 34415495-10 2021 Additionally, hyperoside reversed the regulation of rotenone on the Beclin1, LC3II, Bax, cleaved caspase 3, Cyc and Bcl-2 expressions in rat SNpc tissues and SH-SY5Y cells, while promoted the regulation of rotenone on the P62 and alpha-synuclcin. Rotenone 52-60 BCL2 associated X, apoptosis regulator Rattus norvegicus 84-87 34656609-11 2022 These results were correlated with reduction in alpha-synuclein immunoreactivity, together with improvement of Bax/Bcl2 ratio compared to rotenone group. Rotenone 138-146 BCL2 associated X, apoptosis regulator Rattus norvegicus 111-114 31368148-3 2019 The results showed that rotenone caused apoptosis to PC-12 cells by elevating Bax/Bcl-2 ratio and increasing caspase-3 activity. Rotenone 24-32 BCL2 associated X, apoptosis regulator Rattus norvegicus 78-81 27180985-7 2016 RESULTS: Treatment with rotenone significantly increased the number of apoptotic cells, accompanied by marked increases in the Bax/Bcl-2 ratio, cytochrome c release and caspase-3 activation. Rotenone 24-32 BCL2 associated X, apoptosis regulator Rattus norvegicus 127-130 27688248-5 2016 PF and beta-Ecd cooperate to attenuate the rotenone-induced apoptosis by decrease in Bax expression, caspase-9 activity, and caspase-3 activity. Rotenone 43-51 BCL2 associated X, apoptosis regulator Rattus norvegicus 85-88 27514753-10 2017 These results were correlated with reduction in caspase-3 activity and alpha-synuclein expression, along with improvement of midbrain and striatal Bax/Bcl2 ratio compared to rotenone-treated group. Rotenone 174-182 BCL2 associated X, apoptosis regulator Rattus norvegicus 147-150 25423838-10 2014 Western blot showed that Bcl-2, Bax and Caspase-3 expression in rotenone-induced PC12 cells was reversed by baicalin. Rotenone 64-72 BCL2 associated X, apoptosis regulator Rattus norvegicus 32-35 25813492-0 2015 NAD+ treatment can prevent rotenone-induced increases in DNA damage, Bax levels and nuclear translocation of apoptosis-inducing factor in differentiated PC12 cells. Rotenone 27-35 BCL2 associated X, apoptosis regulator Rattus norvegicus 69-72 25813492-5 2015 We found that NAD(+) treatment can markedly attenuate the rotenone-induced increases in the levels of Bax and nuclear translocation of AIF in the cells. Rotenone 58-66 BCL2 associated X, apoptosis regulator Rattus norvegicus 102-105 23714208-0 2013 p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson"s disease. Rotenone 76-84 BCL2 associated X, apoptosis regulator Rattus norvegicus 23-26 23714208-7 2013 In cultured PC12 cells, rotenone also induced an upregulation of p38(MAPK), P-p38(MAPK), p53 and Bax. Rotenone 24-32 BCL2 associated X, apoptosis regulator Rattus norvegicus 97-100 23714208-10 2013 Inhibition of p53 with pifthrin-alpha or Bax with siRNAs significantly reduced rotenone-induced Bax induction and apoptotic cell death. Rotenone 79-87 BCL2 associated X, apoptosis regulator Rattus norvegicus 41-44 23714208-10 2013 Inhibition of p53 with pifthrin-alpha or Bax with siRNAs significantly reduced rotenone-induced Bax induction and apoptotic cell death. Rotenone 79-87 BCL2 associated X, apoptosis regulator Rattus norvegicus 96-99 23714208-11 2013 These results suggest that the p38(MAPK)/p53-dependent induction of Bax contributes to rotenone"s neurotoxicity in PD models. Rotenone 87-95 BCL2 associated X, apoptosis regulator Rattus norvegicus 68-71 23714208-2 2013 In the present study, we investigated the induction of p38(MAPK)/p53 and Bax in SNpc of Lewis rats after chronic treatment with rotenone and the contribution of Bax to rotenone-induced apoptotic commitment of differentiated PC12 cells. Rotenone 168-176 BCL2 associated X, apoptosis regulator Rattus norvegicus 161-164 19224578-3 2009 To better characterize the role of Bax intracellular shuttling ER cell death signaling and necrotic-like cell death, we used rotenone-treated P5 neuronal cortical cultures to increase ER Bax levels and subsequent cell death signaling. Rotenone 125-133 BCL2 associated X, apoptosis regulator Rattus norvegicus 35-38 22942730-4 2012 Increased oxidized proteins and peroxynitrite, and mitochondrial or cytosol translocation of Bim, Bax or cytochrome c in the striatum was observed after 2-4 weeks of rotenone infusion. Rotenone 166-174 BCL2 associated X, apoptosis regulator Rattus norvegicus 98-101 22942730-7 2012 We conclude that chronic rotenone intoxication may enhance oxidative and nitrosative stress that induces mitochondrial dysfunction and ultrastructural damage, resulting in translocation of Bim and Bax from cytosol to mitochondria that contributes to apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade. Rotenone 25-33 BCL2 associated X, apoptosis regulator Rattus norvegicus 197-200 19224578-0 2009 Bax shuttling after rotenone treatment of neuronal primary cultures: effects on cell death phenotypes. Rotenone 20-28 BCL2 associated X, apoptosis regulator Rattus norvegicus 0-3 19224578-3 2009 To better characterize the role of Bax intracellular shuttling ER cell death signaling and necrotic-like cell death, we used rotenone-treated P5 neuronal cortical cultures to increase ER Bax levels and subsequent cell death signaling. Rotenone 125-133 BCL2 associated X, apoptosis regulator Rattus norvegicus 187-190 19224578-5 2009 The 25 microM rotenone treatment promptly increased nuclear Bax levels followed by a later increase in mitochondrial Bax levels and caspase-mediated cleavage of alpha-fodrin. Rotenone 14-22 BCL2 associated X, apoptosis regulator Rattus norvegicus 60-63 19224578-5 2009 The 25 microM rotenone treatment promptly increased nuclear Bax levels followed by a later increase in mitochondrial Bax levels and caspase-mediated cleavage of alpha-fodrin. Rotenone 14-22 BCL2 associated X, apoptosis regulator Rattus norvegicus 117-120 19224578-6 2009 The 100 microM rotenone treatment also resulted in an early increase in nuclear Bax levels followed by a subsequent increase in ER Bax levels and calpain-mediated cleavage of alpha-fodrin. Rotenone 15-23 BCL2 associated X, apoptosis regulator Rattus norvegicus 80-83 19224578-6 2009 The 100 microM rotenone treatment also resulted in an early increase in nuclear Bax levels followed by a subsequent increase in ER Bax levels and calpain-mediated cleavage of alpha-fodrin. Rotenone 15-23 BCL2 associated X, apoptosis regulator Rattus norvegicus 131-134 19224578-7 2009 After pretreatment with the immunosuppressive and neuroprotective FK506, there was a delay in Bax intracellular shifts and cell death signaling for both the 25 and 100 microM rotenone treatments. Rotenone 175-183 BCL2 associated X, apoptosis regulator Rattus norvegicus 94-97 19224578-8 2009 These results suggest that the different outcomes of apoptotic-like vs. necrotic-like cell death resulting from the treatment of neuronal cultures with rotenone at 25 and 100 microM rotenone reflect changes in the intracellular trafficking of Bax among different organelles. Rotenone 152-160 BCL2 associated X, apoptosis regulator Rattus norvegicus 243-246 19224578-8 2009 These results suggest that the different outcomes of apoptotic-like vs. necrotic-like cell death resulting from the treatment of neuronal cultures with rotenone at 25 and 100 microM rotenone reflect changes in the intracellular trafficking of Bax among different organelles. Rotenone 182-190 BCL2 associated X, apoptosis regulator Rattus norvegicus 243-246