PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19073440-3	2008	Here we selectively expressed constitutively active GSK3beta within the mitochondria and found that this enhanced the apoptosis signaling activated by the PD-mimetic NADH:ubiquinone oxidoreductase (complex I) inhibitors 1-methyl-4-phenylpyridinium ion (MPP+) and rotenone.	Rotenone	263-271	glycogen synthase kinase 3 beta	Homo sapiens	52-60	
19073440-6	2008	Conversely, chemical inhibitors of GSK3beta inhibited MPP+- and rotenone-induced apoptosis, and attenuated the mitochondrial GSK3beta-mediated impairment in complex I.	Rotenone	64-72	glycogen synthase kinase 3 beta	Homo sapiens	35-43	
28930531-6	2018	Taken together, our results suggested that ILF attenuated rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3 beta signaling pathways.	Rotenone	58-66	glycogen synthase kinase 3 beta	Homo sapiens	168-178	
18508033-0	2008	GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells.	Rotenone	50-58	glycogen synthase kinase 3 beta	Homo sapiens	0-8	
18508033-5	2008	We showed that rotenone activated GSK3beta by enhancing its phosphorylation at tyrosine 216 while inhibiting phosphorylation at serine 9.	Rotenone	15-23	glycogen synthase kinase 3 beta	Homo sapiens	34-42	
18508033-6	2008	Inhibitors of GSK3beta and dominant negative (kinase deficient) GSK3beta partially protected SK-N-MC cells against rotenone cytotoxicity.	Rotenone	115-123	glycogen synthase kinase 3 beta	Homo sapiens	14-22	
18508033-6	2008	Inhibitors of GSK3beta and dominant negative (kinase deficient) GSK3beta partially protected SK-N-MC cells against rotenone cytotoxicity.	Rotenone	115-123	glycogen synthase kinase 3 beta	Homo sapiens	64-72	
18508033-13	2008	Taken together, the results suggest that GSK3beta activation and ER stress contribute separately to rotenone cytotoxicity.	Rotenone	100-108	glycogen synthase kinase 3 beta	Homo sapiens	41-49	
11689167-9	2001	Rotenone-induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium.	Rotenone	0-8	glycogen synthase kinase 3 beta	Homo sapiens	89-97	
11689167-9	2001	Rotenone-induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium.	Rotenone	0-8	glycogen synthase kinase 3 beta	Homo sapiens	141-149	
11689167-10	2001	Overall, these results indicate that inhibition of GSK3beta provides protection against the toxic effects of agents, such as MPP and rotenone, that impair mitochondrial function.	Rotenone	133-141	glycogen synthase kinase 3 beta	Homo sapiens	51-59	
29435803-0	2018	Rifampicin Prevents SH-SY5Y Cells from Rotenone-Induced Apoptosis via the PI3K/Akt/GSK-3beta/CREB Signaling Pathway.	Rotenone	39-47	glycogen synthase kinase 3 beta	Homo sapiens	83-92	
29435803-3	2018	This study aims to investigate whether rifampicin protects rotenone-lesioned SH-SY5Y cells via regulating PI3K/Akt/GSK-3beta/CREB pathway.	Rotenone	59-67	glycogen synthase kinase 3 beta	Homo sapiens	115-124	
28855526-7	2017	Additionally, we confirmed that baicalein enhanced mitobiogenesis through the cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3beta (GSK-3beta) pathways in rotenone-treated SH-SY5Y cells.	Rotenone	184-192	glycogen synthase kinase 3 beta	Homo sapiens	129-159	
22922102-0	2012	Glycogen synthase kinase-3beta activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization.	Rotenone	51-59	glycogen synthase kinase 3 beta	Homo sapiens	0-30	
22922102-3	2012	In this study, we investigated glycogen synthase kinase-3beta (GSK3beta) involvement in rotenone-induced microtubule destabilization.	Rotenone	88-96	glycogen synthase kinase 3 beta	Homo sapiens	31-61	
22922102-3	2012	In this study, we investigated glycogen synthase kinase-3beta (GSK3beta) involvement in rotenone-induced microtubule destabilization.	Rotenone	88-96	glycogen synthase kinase 3 beta	Homo sapiens	63-71	
22922102-4	2012	Rotenone-induced cytotoxicity in SH-SY5Y cells was attenuated by the GSK3beta inhibitor SB216763.	Rotenone	0-8	glycogen synthase kinase 3 beta	Homo sapiens	69-77	
22922102-12	2012	Taken together, these results suggest that rotenone-induced cytotoxicity is mediated by microtubule destabilization via GSK3beta activation, and that microtubule destabilization is caused by reduction in the binding capacity of tau to microtubules, which is a result of tau phosphorylation via GSK3beta activation.	Rotenone	43-51	glycogen synthase kinase 3 beta	Homo sapiens	120-128	
22922102-12	2012	Taken together, these results suggest that rotenone-induced cytotoxicity is mediated by microtubule destabilization via GSK3beta activation, and that microtubule destabilization is caused by reduction in the binding capacity of tau to microtubules, which is a result of tau phosphorylation via GSK3beta activation.	Rotenone	43-51	glycogen synthase kinase 3 beta	Homo sapiens	294-302