PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26843528-6	2016	ATR-101 caused mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion within hours after exposure, followed by cytochrome c release, caspase-3/7 activation, and membrane permeabilization.	reactive oxygen	48-63	ATR serine/threonine kinase	Homo sapiens	0-3	
26843528-8	2016	When combined with ATR-101, lipophilic free radical scavengers suppressed the reactive oxygen release, and glycolytic precursors prevented the ATP depletion, abrogating ATR-101 cytotoxicity.	reactive oxygen	78-93	ATR serine/threonine kinase	Homo sapiens	19-22	
26843528-10	2016	ATR-101 administration to guinea pigs caused oxidized lipofuscin accumulation in the zona fasciculate layer of the adrenal cortex, implicating reactive oxygen release in the adrenalytic effect of ATR-101.	reactive oxygen	143-158	ATR serine/threonine kinase	Homo sapiens	196-199