PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15283848-1 2004 We have previously shown that human umbilical vein endothelial cells (HUVEC) can be activated by IFNgamma plus TNFalpha to kill intracellular (IC) Pseudomonas aeruginosa through production of reactive oxygen intermediate, but the cumulative effects of cytokine activation and bacterial infection on host cells has not been extensively addressed. reactive oxygen 192-207 interferon gamma Homo sapiens 97-105 21321110-7 2011 Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors. reactive oxygen 93-108 interferon gamma Homo sapiens 56-65 7927758-12 1994 These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide. reactive oxygen 330-345 interferon gamma Homo sapiens 132-141 8039809-8 1994 It is concluded therefore, that IFN-gamma enhanced the cytotoxicity of freshly isolated human blood monocytes by increasing reactive oxygen intermediate generation but was unable to enhance the tumoricidal competence of macrophages as reactive nitrogen intermediate production was unaffected. reactive oxygen 124-139 interferon gamma Homo sapiens 32-41