PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29638121-6 2018 We also developed bacterial-selective prodrugs (reductively activated quinone-alkyloxycarbonyloxymethyl moiety) to afford HP 87, which demonstrated excellent antibacterial and biofilm eradication activities against MRSA BAA-1707 (MIC = 0.15 muM, MBEC = 12.5 muM). quinone 70-77 latexin Homo sapiens 241-244 29638121-6 2018 We also developed bacterial-selective prodrugs (reductively activated quinone-alkyloxycarbonyloxymethyl moiety) to afford HP 87, which demonstrated excellent antibacterial and biofilm eradication activities against MRSA BAA-1707 (MIC = 0.15 muM, MBEC = 12.5 muM). quinone 70-77 latexin Homo sapiens 258-261 28456030-8 2017 These values are comparable to those recorded for 1,4-benzoquinone of 4.82 muM (MAO-A) and 10.2 muM (MAO-B). quinone 50-66 latexin Homo sapiens 75-78 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 229-232 21953684-7 2014 Benzene metabolites could not influence HaeIII DNMT activity except that 1,4-benzoquinone shows significantly inhibiting effect on enzymatic methylation reaction at concentrations of 5 muM (p < 0.05). quinone 73-89 latexin Homo sapiens 185-188 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 66-82 latexin Homo sapiens 290-293 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 210-226 latexin Homo sapiens 290-293 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 90-93 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 132-135 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 132-135 21570285-2 2011 Most of these compounds show selective action favored to human cancer cell lines over normal cell lines, and compound 9 with bis-terminal benzoquinone functionality exhibits an IC(50)=0.40 muM against MCF7 cell lines. quinone 138-150 latexin Homo sapiens 189-192 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 263-266 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 263-266 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 76-90 latexin Homo sapiens 213-216 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 76-90 latexin Homo sapiens 240-243 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 92-94 latexin Homo sapiens 213-216 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 92-94 latexin Homo sapiens 240-243