PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 Dual oxidase 1 Caenorhabditis elegans 297-302