PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16774642-3	2006	We propose that the enzyme is a member of the DHODH family 2, which comprises mitochondrially bound enzymes, with quinone as the direct electron acceptor and oxygen as the final electron acceptor.	quinone	114-121	dihydroorotate dehydrogenase (quinone)	Homo sapiens	46-51	
17369345-6	2007	The biochemical characterization of purified U. maydis DHODH overproduced in Escherichia coli revealed that the U. maydis enzyme uses quinone electron acceptor Q6 and is resistant to several commonly used DHODH inhibitors.	quinone	134-141	dihydroorotate dehydrogenase (quinone)	Homo sapiens	55-60	
17369345-6	2007	The biochemical characterization of purified U. maydis DHODH overproduced in Escherichia coli revealed that the U. maydis enzyme uses quinone electron acceptor Q6 and is resistant to several commonly used DHODH inhibitors.	quinone	134-141	dihydroorotate dehydrogenase (quinone)	Homo sapiens	205-210	
30664899-6	2019	Well-known class 2 DHODH inhibitors were tested against SmDHODH and HsDHODH and the results suggest that the variable nature of the quinone-binding tunnel between human and parasite enzymes, as well as the differences in structural plasticity involving rearrangements of the N-terminal alpha-helical domain can be exploited for the design of SmDHODH selective inhibitors, as a strategy to validate DHODH as a drug target against schistosomiasis.	quinone	132-139	dihydroorotate dehydrogenase (quinone)	Homo sapiens	19-24	
30664899-6	2019	Well-known class 2 DHODH inhibitors were tested against SmDHODH and HsDHODH and the results suggest that the variable nature of the quinone-binding tunnel between human and parasite enzymes, as well as the differences in structural plasticity involving rearrangements of the N-terminal alpha-helical domain can be exploited for the design of SmDHODH selective inhibitors, as a strategy to validate DHODH as a drug target against schistosomiasis.	quinone	132-139	dihydroorotate dehydrogenase (quinone)	Homo sapiens	58-63