PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27770821-0 2016 The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. quinone 4-20 arachidonate 5-lipoxygenase Homo sapiens 30-44 27836196-0 2017 Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. quinone 16-28 arachidonate 5-lipoxygenase Homo sapiens 88-102 24467325-0 2014 Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase. quinone 75-91 arachidonate 5-lipoxygenase Homo sapiens 106-120 24467325-11 2014 CONCLUSIONS AND IMPLICATIONS: RF-Id represents a novel anti-inflammatory 1,4-benzoquinone that potently suppresses LT biosynthesis by direct inhibition of 5-LOX with effectiveness in vivo. quinone 73-89 arachidonate 5-lipoxygenase Homo sapiens 155-160 23472470-3 2013 In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. quinone 28-35 arachidonate 5-lipoxygenase Homo sapiens 197-211 23472470-8 2013 This process supports the biological data and suggested that, although the redox potential is responsible for the quinone"s activity on multiple targets, in the case of 5-LOX the molecular structure plays a vital role in the inhibition. quinone 114-121 arachidonate 5-lipoxygenase Homo sapiens 169-174 23871907-0 2013 Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. quinone 45-61 arachidonate 5-lipoxygenase Homo sapiens 110-124