PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19908836-2	2010	Optimization of a screening hit using structure-based design and modification of log D and chemical structural features led to the identification of a class of orally bioavailable non-quinone-containing Hsp90 inhibitors.	quinone	184-191	heat shock protein 90 alpha family class A member 1	Homo sapiens	203-208	
21156818-2	2011	The formation of 17AAGH2 by NQO1 results in a molecule that binds with greater affinity to Hsp90 compared with the parent quinone.	quinone	122-129	heat shock protein 90 alpha family class A member 1	Homo sapiens	91-96	
23167798-6	2012	Results show that quinone-derivatives that bear two electroactive groups (namely quinone and nitro) exhibit the highest inhibitory activity (Hsp90 cleavage and cell death).	quinone	18-25	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146	
23167798-6	2012	Results show that quinone-derivatives that bear two electroactive groups (namely quinone and nitro) exhibit the highest inhibitory activity (Hsp90 cleavage and cell death).	quinone	81-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146	
19308924-7	2009	A 15-hydroxyl-17-demethoxy non-quinone analogue, DHQ3, exhibited stronger inhibition of Hsp90 ATPase activity (4.6-fold) than geldanamycin.	quinone	31-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	88-93	
19952119-3	2009	In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the hydroquinone form binding 50 times more tightly to Hsp90.	quinone	40-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	182-187	
19441108-10	2009	Non-quinone Hsp90 inhibitors exhibit tumor-specific accumulation and exert potent antineoplastic activity without causing significant hepatotoxicity.	quinone	4-11	heat shock protein 90 alpha family class A member 1	Homo sapiens	12-17	
17163756-2	2006	They spotlight the higher affinity of ansamycins" hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins" tumor selectivity.	quinone	55-62	heat shock protein 90 alpha family class A member 1	Homo sapiens	89-94	
18393300-3	2008	The hydroquinone derivative of 17AAG, 17AAG hydroquinone (17AAGH(2)), is considerably more water soluble and since we previously demonstrated that 17AAGH(2) was a more potent Hsp90 inhibitor than its parent quinone, it is a good candidate for clinical use and is currently in clinical trials.	quinone	9-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	175-180	
19568319-2	2008	Utilizing our chimera approach, which encompasses the quinone moiety of geldanamycin and the resorcinol moiety of radicicol, molecules have been produced that are highly effective inhibitors of the Hsp90 protein folding machinery.	quinone	54-61	heat shock protein 90 alpha family class A member 1	Homo sapiens	198-203	
17662999-10	2007	Experiments with BDGA measured over a wide range of conditions, in the absence and in the presence of reducing agents, confirm recent studies that have suggested that the reduced dihydroquinone form of the drug binds to Hsp90 considerably more tightly than the non-reduced quinone species.	quinone	186-193	heat shock protein 90 alpha family class A member 1	Homo sapiens	220-225	
15202892-3	2004	In particular, the quinone-containing antibiotics geldanamycin (GDA) and herbimycin A inhibit Hsp90 function in vitro at low micromolar concentrations via interaction with an ATP binding domain.	quinone	19-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99	
15867239-1	2005	PURPOSE: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein 90 (HSP90).	quinone	61-73	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-162	
15867239-1	2005	PURPOSE: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein 90 (HSP90).	quinone	61-73	heat shock protein 90 alpha family class A member 1	Homo sapiens	164-169	
25572106-0	2015	New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.	quinone	9-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70	
25668752-9	2015	These later efforts have led to the discovery of a uniquely selective benzoquinone ansamycin-inspired Hsp90 inhibitor that lacks the problematic quinone present in the natural series.	quinone	75-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	102-107	
32868290-6	2020	Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity.	quinone	75-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	134-139	
32799638-7	2021	Our results provide the bases for a rational modification of new molecules based in quinone scaffold, in order to design more potent Hsp90 inhibitors, which would exhibit highly potent antitumor activity.	quinone	84-91	heat shock protein 90 alpha family class A member 1	Homo sapiens	133-138	
26674599-2	2015	Geldanamycin (GA), a natural benzoquinone, can inhibit the chaperone activity of Hsp90.	quinone	29-41	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-86	
25117641-3	2014	Despite preclinical efficacy of geldanamycin-anasamycin (GA)-derivatives containing benzoquinone moiety as Hsp90 inhibitors, the hepatotoxicity of these GA-derivatives restricts their therapeutic benefit.	quinone	84-96	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-112	
24682466-8	2014	19-Phenyl BQAs inhibited purified Hsp90 in a NAD(P)H: quinone oxidoreductase 1 (NQO1)-dependent manner, demonstrating increased efficacy of the hydroquinone ansamycin relative to its parent quinone.	quinone	54-61	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39	
23710334-2	2013	Previously, we have demonstrated that a quinone-based mimetic dipeptide, named DTNQ-Pro, induced differentiation of growing Caco-2 cells through inhibition of HSP70 and HSP90.	quinone	40-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	169-174