PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21621882-5 2011 The SAR analysis indicates that the location of nitrogen substituents on the quinone nucleus, the presence of methyl, phenyl, furyl and thienyl groups at the 6-position and the aromatization of the angular cycloaliphatic ring of the phenylamino-3,4-tetrahydrophenanthridine-1,7,10(2H)-trione pharmacophore play key roles in the antitumor activity. quinone 77-84 sarcosine dehydrogenase Homo sapiens 4-7