PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21384861-3 2011 In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ. quinone 28-35 kelch-like ECH-associated protein 1 Mus musculus 79-84 22214931-1 2012 In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. quinone 245-252 kelch-like ECH-associated protein 1 Mus musculus 105-110 22214931-1 2012 In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. quinone 245-252 kelch-like ECH-associated protein 1 Mus musculus 209-214 18329808-9 2008 Thus, the most potent active form as the activator of the Keap1/Nrf2 pathway, the quinone-type CA, will be produced inside the cells. quinone 82-89 kelch-like ECH-associated protein 1 Mus musculus 58-63 19952498-0 2009 Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. quinone 84-91 kelch-like ECH-associated protein 1 Mus musculus 106-111