PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19183258-2 2009 The results indicate that with 2-min pretreatment, U18666A inhibited different nAChR subtypes with a rank-order of potency (IC(50) of whole-cell peak current): alpha4beta2 (8.0 +/- 3.0 nM) > alpha3beta2 (1.7 +/- 0.4 microM) > alpha4beta4 (26 +/- 7.2 microM) > alpha7 (> 100 microM), suggesting this compound is more selective to alpha4beta2-nAChRs. 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one 51-58 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 79-84 19183258-6 2009 U18666A-induced inhibition of nAChR function is concentration-, voltage-, and use-dependent, suggesting an open channel block. 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one 0-7 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 30-35