PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23087649-0 2012 Outlook: membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases. Fatty Acids 61-72 acyl-CoA synthetase short chain family member 2 Homo sapiens 90-110 29457784-9 2018 In the SIV-infected nonhuman primate model of AIDS, the expression of ACSS2 was significantly induced in intestinal mucosa in vivo, which correlated with altered fatty acid metabolism. Fatty Acids 162-172 acyl-CoA synthetase short chain family member 2 Homo sapiens 70-75 29457784-10 2018 Our study links the HIV/SIV infection-induced fatty acid enzyme ACSS2 to HIV latency and identifies histone lysine crotonylation as a novel epigenetic regulator for HIV transcription that can be targeted for HIV eradication. Fatty Acids 46-56 acyl-CoA synthetase short chain family member 2 Homo sapiens 64-69 26552674-1 2016 Long-chain fatty acyl-CoA synthetases (ACS) are a family of essential enzymes of lipid metabolism, activating fatty acids by thioesterification with coenzyme A. Fatty Acids 110-121 acyl-CoA synthetase short chain family member 2 Homo sapiens 17-37 26552674-1 2016 Long-chain fatty acyl-CoA synthetases (ACS) are a family of essential enzymes of lipid metabolism, activating fatty acids by thioesterification with coenzyme A. Fatty Acids 110-121 acyl-CoA synthetase short chain family member 2 Homo sapiens 39-42 26552674-4 2016 Recent work suggests that ACS enzymes may drive cellular fatty acid uptake by metabolic trapping, and may also regulate the channeling of fatty acids towards specific metabolic pathways. Fatty Acids 57-67 acyl-CoA synthetase short chain family member 2 Homo sapiens 26-29 26552674-4 2016 Recent work suggests that ACS enzymes may drive cellular fatty acid uptake by metabolic trapping, and may also regulate the channeling of fatty acids towards specific metabolic pathways. Fatty Acids 138-149 acyl-CoA synthetase short chain family member 2 Homo sapiens 26-29 23087649-2 2012 Recently, we showed that mammalian long chain fatty acyl-CoA synthetases (ACS) are not only essential enzymes for lipid metabolism but are also involved in cellular fatty acid uptake. Fatty Acids 165-175 acyl-CoA synthetase short chain family member 2 Homo sapiens 52-72 23087649-2 2012 Recently, we showed that mammalian long chain fatty acyl-CoA synthetases (ACS) are not only essential enzymes for lipid metabolism but are also involved in cellular fatty acid uptake. Fatty Acids 165-175 acyl-CoA synthetase short chain family member 2 Homo sapiens 74-77 23087649-3 2012 Overexpression, RNAi depletion or hormonal stimulation of ACS enzymes lead to corresponding changes of fatty acid uptake. Fatty Acids 103-113 acyl-CoA synthetase short chain family member 2 Homo sapiens 58-61 23087649-4 2012 Remarkably, ACS are not localized to the plasma membrane where fatty acids are entering the cell, but are found instead at the endoplasmic reticulum (ER) or other intracellular organelles like mitochondria and lipid droplets. Fatty Acids 63-74 acyl-CoA synthetase short chain family member 2 Homo sapiens 12-15 23087649-7 2012 Intracellular ACS enzymes are then metabolically trapping fatty acids as acyl-CoA derivatives. Fatty Acids 58-69 acyl-CoA synthetase short chain family member 2 Homo sapiens 14-17 22355267-6 2012 In addition, mRNA levels of several SREBP regulated genes involved in cholesterol and fatty-acid synthesis including ACSS2, FDPS, IDI1, MVD, HMGCR, and CYP51A1 were decreased significantly with antibody treatment of primary human hepatocytes. Fatty Acids 86-96 acyl-CoA synthetase short chain family member 2 Homo sapiens 117-122 11127823-0 2000 Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Fatty Acids 0-10 acyl-CoA synthetase short chain family member 2 Homo sapiens 57-76 18375835-6 2008 The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). Fatty Acids 38-48 acyl-CoA synthetase short chain family member 2 Homo sapiens 109-129 18375835-6 2008 The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). Fatty Acids 38-48 acyl-CoA synthetase short chain family member 2 Homo sapiens 131-134 18375835-8 2008 The purpose of this review is to report on the large family of mammalian long-chain acyl-CoA synthetases (ACSL), which activate fatty acids with chain lengths of 12 to 20 carbon atoms. Fatty Acids 128-139 acyl-CoA synthetase short chain family member 2 Homo sapiens 84-104 11127823-1 2000 Acyl-CoA synthetase (ACS) ligates fatty acid and CoA to produce acyl-CoA, an essential molecule in fatty acid metabolism and cell proliferation. Fatty Acids 34-44 acyl-CoA synthetase short chain family member 2 Homo sapiens 0-19 11127823-1 2000 Acyl-CoA synthetase (ACS) ligates fatty acid and CoA to produce acyl-CoA, an essential molecule in fatty acid metabolism and cell proliferation. Fatty Acids 34-44 acyl-CoA synthetase short chain family member 2 Homo sapiens 21-24 11127823-1 2000 Acyl-CoA synthetase (ACS) ligates fatty acid and CoA to produce acyl-CoA, an essential molecule in fatty acid metabolism and cell proliferation. Fatty Acids 99-109 acyl-CoA synthetase short chain family member 2 Homo sapiens 0-19 11127823-1 2000 Acyl-CoA synthetase (ACS) ligates fatty acid and CoA to produce acyl-CoA, an essential molecule in fatty acid metabolism and cell proliferation. Fatty Acids 99-109 acyl-CoA synthetase short chain family member 2 Homo sapiens 21-24 10843999-10 2000 We conclude that ACS mRNA, and hence the ability of cells to activate acetate, is regulated by SREBPs in parallel with fatty acid synthesis in animal cells. Fatty Acids 119-129 acyl-CoA synthetase short chain family member 2 Homo sapiens 17-20