PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12200230-1	2002	Activity of acetyl-CoA carboxylase (ACC)-alpha is rate limiting for de novo synthesis of fatty acids.	Fatty Acids	89-100	acetyl-CoA carboxylase alpha	Bos taurus	36-46	
35469640-10	2022	Data revealed that both fatty liver and in vitro challenge with fatty acids were associated with greater concentrations of TAG and mRNA and protein abundance of SORT1, SREBF1, FASN, and ACACA.	Fatty Acids	64-75	acetyl-CoA carboxylase alpha	Bos taurus	186-191	
12084579-1	2002	Three promoters express the bovine gene encoding the enzyme acetyl-CoA carboxylase-alpha (ACC alpha) known to be rate-limiting for fatty acid synthesis.	Fatty Acids	131-141	acetyl-CoA carboxylase alpha	Bos taurus	60-88	
12084579-1	2002	Three promoters express the bovine gene encoding the enzyme acetyl-CoA carboxylase-alpha (ACC alpha) known to be rate-limiting for fatty acid synthesis.	Fatty Acids	131-141	acetyl-CoA carboxylase alpha	Bos taurus	90-99	
35469640-12	2022	Compared with fatty acid challenge alone, SORT1 overexpression led to greater concentration of TAG and mRNA abundance of SREBF1, FASN, ACACA, DGAT1, and DGAT2, and protein abundance of SREBF1, FASN, and ACACA.	Fatty Acids	14-24	acetyl-CoA carboxylase alpha	Bos taurus	135-140	
35469640-14	2022	Compared with fatty acid challenge alone, SORT1 inhibitor + fatty acids led to lower concentrations of TAG and mRNA abundance of SREBF1, FASN, and DGAT2, and protein abundance of FASN, ACACA, and DGAT1.	Fatty Acids	60-71	acetyl-CoA carboxylase alpha	Bos taurus	185-190	
33189279-11	2021	The PPARA gene is involved in the regulation of lipid metabolism and fatty liver disease and the ACACA gene encodes an enzyme that catalyzes the carboxylation of acetyl-coenzyme A to malonyl-coenzyme A, which is a rate-limiting step in fatty acid synthesis.	Fatty Acids	236-246	acetyl-CoA carboxylase alpha	Bos taurus	97-102	
32521715-0	2020	Impact of SNPs in ACACA, SCD1, and DGAT1 Genes on Fatty Acid Profile in Bovine Milk with Regard to Lactation Phases.	Fatty Acids	50-60	acetyl-CoA carboxylase alpha	Bos taurus	18-23	
31155263-6	2019	In addition, fatty acid treatment increased the abundance of sterol regulatory element-binding protein 1c, acetyl-CoA carboxylase-alpha, fatty acid synthase, and diacylglycerol acyltransferase 1, and lipid accumulation in calf primary hepatocytes, whereas inhibition of ER stress by incubating with TUDCA significantly weakened these effects.	Fatty Acids	13-23	acetyl-CoA carboxylase alpha	Bos taurus	61-135	
22738246-1	2012	BACKGROUND: The enzyme acetyl-CoA carboxylase-alpha (ACC-alpha) is rate limiting for de novo fatty acid synthesis.	Fatty Acids	93-103	acetyl-CoA carboxylase alpha	Bos taurus	23-51	
22738246-1	2012	BACKGROUND: The enzyme acetyl-CoA carboxylase-alpha (ACC-alpha) is rate limiting for de novo fatty acid synthesis.	Fatty Acids	93-103	acetyl-CoA carboxylase alpha	Bos taurus	53-62	
12871989-1	2003	The activity of the enzyme acetyl-CoA-carboxylase alpha (ACC-alpha) is rate limiting for the de novo synthesis of fatty acids.	Fatty Acids	114-125	acetyl-CoA carboxylase alpha	Bos taurus	27-55	
12871989-1	2003	The activity of the enzyme acetyl-CoA-carboxylase alpha (ACC-alpha) is rate limiting for the de novo synthesis of fatty acids.	Fatty Acids	114-125	acetyl-CoA carboxylase alpha	Bos taurus	57-66	
32331890-9	2020	Fatty acid (1 mM) treatment also markedly increased the abundance of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) but significantly decreased the abundance of carnitine palmitoyltransferase I (CPT1A), carnitine palmitoyltransferase II (CPT2), and acyl-CoA oxidase (ACO).	Fatty Acids	0-10	acetyl-CoA carboxylase alpha	Bos taurus	69-93	
32331890-9	2020	Fatty acid (1 mM) treatment also markedly increased the abundance of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) but significantly decreased the abundance of carnitine palmitoyltransferase I (CPT1A), carnitine palmitoyltransferase II (CPT2), and acyl-CoA oxidase (ACO).	Fatty Acids	0-10	acetyl-CoA carboxylase alpha	Bos taurus	95-99	
31993168-7	2020	The results showed that CO increased the expression of genes related to de novo synthesis of fatty acids including sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1 (ACC), fatty acid synthase (FASN), lipoprotein lipase (LPL), and stearoyl-CoA desaturase (SCD) (p < .05).	Fatty Acids	93-104	acetyl-CoA carboxylase alpha	Bos taurus	169-193	
26995140-12	2016	Two candidate genes on BTA19 (CCL3 and ACACA) were relevantly associated with de novo short- and medium-chain fatty acids, likely explaining the high heritability values found for these fatty acids (with the exception of C6:0).	Fatty Acids	110-121	acetyl-CoA carboxylase alpha	Bos taurus	39-44	
22718502-0	2012	The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk.	Fatty Acids	44-54	acetyl-CoA carboxylase alpha	Bos taurus	16-21	
22718502-10	2012	Since PIII is the promoter specific to mammary gland during lactation, the altered expression of the ACACA gene owing to the SNPs in the PIII region may influence the fatty acid composition in the milk.	Fatty Acids	167-177	acetyl-CoA carboxylase alpha	Bos taurus	101-106	
20002363-10	2010	Our results suggested that the SNPs in the PI region of ACACA gene are associated with variations in the fatty acid contents in LM.	Fatty Acids	105-115	acetyl-CoA carboxylase alpha	Bos taurus	56-61	
19747896-3	2009	Treatment of MAC-T with an AMPK activator dramatically decreased de novo fatty acid synthesis by inactivating acetyl-CoA carboxylase-alpha.	Fatty Acids	73-83	acetyl-CoA carboxylase alpha	Bos taurus	110-138