PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34100951-9 2021 In a subsequent study, hepatocytes were transfected with small interfering RNA (siORAI1) or the ORAI1 inhibitor BTP2 for 48 h or 2 h followed by a challenge with the 1.2 mM mixture of fatty acids for 6 h. Compared with control group, silencing or inhibition of ORAI1 led to decreased abundance of fatty acid synthesis (FASN, SREBP1 and ACACA) and ER stress-related proteins in bovine hepatocytes. Fatty Acids 297-307 fatty acid synthase Bos taurus 319-323 34438882-7 2021 The genomic regions (1Mb) which were associated with more than one fatty acid trait with high genetic variance and harbored good candidate genes were on Chromosome (Chr) 6 (fatty acid binding protein 2), Chr 19 (thyroid hormone receptor alpha, fatty acid synthase), Chr 26 (stearoyl-CoA desaturase), and Chr 29 (thyroid hormone responsive, fatty acid desaturase 2, and fatty acid desaturase 3). Fatty Acids 67-77 fatty acid synthase Bos taurus 244-263 35469640-10 2022 Data revealed that both fatty liver and in vitro challenge with fatty acids were associated with greater concentrations of TAG and mRNA and protein abundance of SORT1, SREBF1, FASN, and ACACA. Fatty Acids 64-75 fatty acid synthase Bos taurus 176-180 35469640-12 2022 Compared with fatty acid challenge alone, SORT1 overexpression led to greater concentration of TAG and mRNA abundance of SREBF1, FASN, ACACA, DGAT1, and DGAT2, and protein abundance of SREBF1, FASN, and ACACA. Fatty Acids 14-24 fatty acid synthase Bos taurus 129-133 35469640-14 2022 Compared with fatty acid challenge alone, SORT1 inhibitor + fatty acids led to lower concentrations of TAG and mRNA abundance of SREBF1, FASN, and DGAT2, and protein abundance of FASN, ACACA, and DGAT1. Fatty Acids 14-24 fatty acid synthase Bos taurus 137-141 35469640-14 2022 Compared with fatty acid challenge alone, SORT1 inhibitor + fatty acids led to lower concentrations of TAG and mRNA abundance of SREBF1, FASN, and DGAT2, and protein abundance of FASN, ACACA, and DGAT1. Fatty Acids 60-71 fatty acid synthase Bos taurus 137-141 35469640-14 2022 Compared with fatty acid challenge alone, SORT1 inhibitor + fatty acids led to lower concentrations of TAG and mRNA abundance of SREBF1, FASN, and DGAT2, and protein abundance of FASN, ACACA, and DGAT1. Fatty Acids 60-71 fatty acid synthase Bos taurus 179-183 32689797-11 2020 Overall, data suggest that circ09863 relieves the inhibitory effect of miR-27a-3p on FASN expression by binding miR-27a-3p and subsequently regulating TAG synthesis and fatty acid composition. Fatty Acids 169-179 fatty acid synthase Bos taurus 85-89 35181144-8 2022 Data indicated that both fatty liver and in vitro challenge with fatty acids were associated with greater mRNA and protein abundance of SREBF1, FASN, DGAT1, and DGAT2. Fatty Acids 65-76 fatty acid synthase Bos taurus 144-148 35181144-12 2022 Compared with fatty acid challenge alone, DGAT2 inhibitor + fatty acids led to greater mRNA and protein abundance of CPT1A, MTTP, and APOB, and lower mRNA and protein abundance of SREBF1 and FASN. Fatty Acids 14-24 fatty acid synthase Bos taurus 191-195 35181144-12 2022 Compared with fatty acid challenge alone, DGAT2 inhibitor + fatty acids led to greater mRNA and protein abundance of CPT1A, MTTP, and APOB, and lower mRNA and protein abundance of SREBF1 and FASN. Fatty Acids 60-71 fatty acid synthase Bos taurus 191-195 32331890-9 2020 Fatty acid (1 mM) treatment also markedly increased the abundance of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) but significantly decreased the abundance of carnitine palmitoyltransferase I (CPT1A), carnitine palmitoyltransferase II (CPT2), and acyl-CoA oxidase (ACO). Fatty Acids 0-10 fatty acid synthase Bos taurus 105-124 32331890-9 2020 Fatty acid (1 mM) treatment also markedly increased the abundance of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) but significantly decreased the abundance of carnitine palmitoyltransferase I (CPT1A), carnitine palmitoyltransferase II (CPT2), and acyl-CoA oxidase (ACO). Fatty Acids 0-10 fatty acid synthase Bos taurus 126-129 26376068-1 2016 Fatty Acid Synthase (FASN) gene seems to be structurally and functionally different in bovines in view of their distinctive fatty acid synthesis process. Fatty Acids 124-134 fatty acid synthase Bos taurus 0-19 31993168-7 2020 The results showed that CO increased the expression of genes related to de novo synthesis of fatty acids including sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1 (ACC), fatty acid synthase (FASN), lipoprotein lipase (LPL), and stearoyl-CoA desaturase (SCD) (p < .05). Fatty Acids 93-104 fatty acid synthase Bos taurus 201-220 31993168-7 2020 The results showed that CO increased the expression of genes related to de novo synthesis of fatty acids including sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1 (ACC), fatty acid synthase (FASN), lipoprotein lipase (LPL), and stearoyl-CoA desaturase (SCD) (p < .05). Fatty Acids 93-104 fatty acid synthase Bos taurus 222-226 31304752-5 2019 FASN, LPIN1, PPARalpha, and PPARgamma transcripts were more sensitive to the short-chain FAs (acetic and beta-hydroxybutyric acids). Fatty Acids 89-92 fatty acid synthase Bos taurus 0-4 31155263-6 2019 In addition, fatty acid treatment increased the abundance of sterol regulatory element-binding protein 1c, acetyl-CoA carboxylase-alpha, fatty acid synthase, and diacylglycerol acyltransferase 1, and lipid accumulation in calf primary hepatocytes, whereas inhibition of ER stress by incubating with TUDCA significantly weakened these effects. Fatty Acids 13-23 fatty acid synthase Bos taurus 137-156 29273553-1 2018 Fatty acid synthase (FASN) is an enzyme involved with fat deposition and fatty acid composition in cattle. Fatty Acids 73-83 fatty acid synthase Bos taurus 0-19 29273553-1 2018 Fatty acid synthase (FASN) is an enzyme involved with fat deposition and fatty acid composition in cattle. Fatty Acids 73-83 fatty acid synthase Bos taurus 21-25 29892799-4 2018 FASN is an essential metabolic and multifunctional enzyme in fatty acid synthesis. Fatty Acids 61-71 fatty acid synthase Bos taurus 0-4 28615065-5 2017 We further obtained several candidate genes which may be involved in fatty acid biosynthesis including elongation of very long chain fatty acids protein 5 (ELOVL5), fatty acid synthase (FASN), caspase 2 (CASP2) and thyroglobulin (TG). Fatty Acids 69-79 fatty acid synthase Bos taurus 165-184 28615065-5 2017 We further obtained several candidate genes which may be involved in fatty acid biosynthesis including elongation of very long chain fatty acids protein 5 (ELOVL5), fatty acid synthase (FASN), caspase 2 (CASP2) and thyroglobulin (TG). Fatty Acids 69-79 fatty acid synthase Bos taurus 186-190 28615065-10 2017 Using multiple methods, our results revealed that FASN and ELOVL5 are associated with fatty acids with strong evidence. Fatty Acids 86-97 fatty acid synthase Bos taurus 50-54 26249527-4 2016 These genes are SCD, FASN and SREBP1, which are associated with the fatty acid composition of meat, and NCAPG, MC1R and F11, which are associated with carcass weight, coat color and blood coagulation abnormality, respectively. Fatty Acids 68-78 fatty acid synthase Bos taurus 21-25 26720887-2 2016 Single-locus genotype effects and the combined effect of the two polymorphisms within the FASN gene were evaluated for association with the intramuscular fat content and fatty acid profile determined in muscle and subcutaneous fat. Fatty Acids 170-180 fatty acid synthase Bos taurus 90-94 26376068-1 2016 Fatty Acid Synthase (FASN) gene seems to be structurally and functionally different in bovines in view of their distinctive fatty acid synthesis process. Fatty Acids 124-134 fatty acid synthase Bos taurus 21-25 25597874-0 2015 The g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle. Fatty Acids 52-62 fatty acid synthase Bos taurus 23-27 25597874-1 2015 The objective of the current study is to evaluate the association between fatty acid composition and fatty acid synthase gene polymorphisms as responsible mutations. Fatty Acids 74-84 fatty acid synthase Bos taurus 101-120 24792801-10 2014 The mammary mRNA abundance of PPARG (-32%) and FASN (-29%) was lower in grazing compared with confined cows, which was accompanied by reduced (-43%) secretion of de novo synthesized fatty acids in milk. Fatty Acids 182-193 fatty acid synthase Bos taurus 47-51 24565561-5 2014 SREBP-1c overexpression significantly up-regulated the expression and activity of the fatty acid uptake, activation, and synthesis enzymes: liver fatty acid binding protein, fatty acid translocase, acyl-CoA synthetase long-chain 1, acetyl-CoA carboxylase 1, and fatty acid synthase, increasing triglyceride (TG) synthesis and accumulation. Fatty Acids 86-96 fatty acid synthase Bos taurus 262-281 24858810-6 2014 Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Fatty Acids 93-103 fatty acid synthase Bos taurus 290-294 24745147-2 2014 It has been suggested that the FASN gene is effective on fatty acid composition of meat in cattle. Fatty Acids 57-67 fatty acid synthase Bos taurus 31-35 24015912-1 2014 Fatty acid synthase (FASN) is a multifunctional protein that catalyzes de novo synthesis of fatty acids in cells. Fatty Acids 92-103 fatty acid synthase Bos taurus 0-19 24015912-1 2014 Fatty acid synthase (FASN) is a multifunctional protein that catalyzes de novo synthesis of fatty acids in cells. Fatty Acids 92-103 fatty acid synthase Bos taurus 21-25 24704238-5 2014 The expression of key genes related to de novo fatty acid synthesis (FASN) and desaturation (SCD) was upregulated by HE compared with LE. Fatty Acids 47-57 fatty acid synthase Bos taurus 69-73 22497525-1 2012 The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition. Fatty Acids 4-14 fatty acid synthase Bos taurus 25-29 23607548-6 2013 Association analysis revealed that 30 significant SNPs for several fatty acids (C14:0, C14:1, C16:1 and C18:1) were located in the BTA19 FASN gene located within this region but the FASN mutation had no significant effect on any traits. Fatty Acids 67-78 fatty acid synthase Bos taurus 137-141 23403305-0 2013 Genetic variation of FASN is associated with fatty acid composition of Hanwoo. Fatty Acids 45-55 fatty acid synthase Bos taurus 21-25 23403305-1 2013 The objective of this study was to identify genetic variants in the bovine fatty acid synthase (FASN) gene and to evaluate associations with fatty acid composition from longissimus lumborum muscle using 90 purebred Hanwoo steers. Fatty Acids 75-85 fatty acid synthase Bos taurus 96-100 22497525-5 2012 Although the individual effects of FASN and SCD polymorphisms on fatty acid composition were small, overall gene substitution may effectively improve fatty acid composition. Fatty Acids 150-160 fatty acid synthase Bos taurus 35-39 22851248-14 2012 Supplementation of palmitoleic acid to bovine adipocytes results in increased incorporation of this fatty acid and its elongation products into the adipocyte, which downregulates SCD1, FASN, and ELOVL6 to decrease lipogenesis and upregulates CPT1A, potentially increasing beta-oxidation. Fatty Acids 100-110 fatty acid synthase Bos taurus 185-189 22223295-7 2012 The results indicate that SNPs in three candidate genes, FABP4, FASN and SCD, may be influential in breeding design for fatty acid composition in Hanwoo. Fatty Acids 120-130 fatty acid synthase Bos taurus 64-68 22221030-4 2012 Significant epistatic effects between the SCD and FASN SNP genotypes were also found for several fatty acids including 10:0, 23:0, 6t/7t/8t-18:1, 12t-18:1, 13t/14t-18:1, 16t-18:1, total trans18:1 and 9c,13t/8t,12c-18:2 (P < 0.05). Fatty Acids 97-108 fatty acid synthase Bos taurus 50-54 21773945-0 2012 Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN. Fatty Acids 0-10 fatty acid synthase Bos taurus 98-102 21773945-1 2012 Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. Fatty Acids 24-34 fatty acid synthase Bos taurus 119-138 21773945-1 2012 Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. Fatty Acids 24-34 fatty acid synthase Bos taurus 140-144 21773945-6 2012 We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Fatty Acids 120-130 fatty acid synthase Bos taurus 97-101 22221030-5 2012 These results further suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle. Fatty Acids 87-97 fatty acid synthase Bos taurus 43-47 20852082-3 2011 Among lipid metabolism-related genes, including fatty acid synthesis genes, several genetic variations have been reported in the bovine fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein 1 (SREBP1), and GH genes. Fatty Acids 48-58 fatty acid synthase Bos taurus 136-155 20852082-3 2011 Among lipid metabolism-related genes, including fatty acid synthesis genes, several genetic variations have been reported in the bovine fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein 1 (SREBP1), and GH genes. Fatty Acids 48-58 fatty acid synthase Bos taurus 157-161 20852082-4 2011 In the present study, we evaluated the single and epistatic effects of 5 genetic variations (4 SNP and 1 insertion/deletion) in 4 genes (FASN, SCD, SREBP1, and GH) on the fatty acid composition of the longissimus thoracis muscle and carcass and meat quality traits in 480 commercial Japanese Black cattle. Fatty Acids 171-181 fatty acid synthase Bos taurus 137-141 20852082-5 2011 Significant single effects of FASN, SCD, and GH(L127V) polymorphisms on the fatty acid composition of the longissimus thoracis muscle were detected. Fatty Acids 76-86 fatty acid synthase Bos taurus 30-34 20852082-12 2011 The present results revealed that polymorphisms in 2 fatty acid synthesis genes (FASN and SCD) independently influenced fatty acid composition in the longissimus thoracis muscle. Fatty Acids 53-63 fatty acid synthase Bos taurus 81-85 20852082-12 2011 The present results revealed that polymorphisms in 2 fatty acid synthesis genes (FASN and SCD) independently influenced fatty acid composition in the longissimus thoracis muscle. Fatty Acids 120-130 fatty acid synthase Bos taurus 81-85 20852082-13 2011 These results suggest that SNP in the FASN and SCD genes are useful markers for the improvement of fatty acid composition in commercial Japanese Black cattle. Fatty Acids 99-109 fatty acid synthase Bos taurus 38-42 19291389-0 2009 Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beef. Fatty Acids 53-63 fatty acid synthase Bos taurus 23-27 17242864-7 2007 It is concluded that SNPs in the bovine FASN gene are associated with variation in the fatty acid composition of adipose fat and milk fat. Fatty Acids 87-97 fatty acid synthase Bos taurus 40-44 18477667-1 2008 Fatty acid synthase (FASN) is an enzyme that catalyzes de novo synthesis of fatty acids in cells. Fatty Acids 76-87 fatty acid synthase Bos taurus 0-19 18477667-1 2008 Fatty acid synthase (FASN) is an enzyme that catalyzes de novo synthesis of fatty acids in cells. Fatty Acids 76-87 fatty acid synthase Bos taurus 21-25 16734679-1 2006 Fatty acid synthase (FASN) is a multifunctional protein that carries out the synthesis of fatty acids so it plays a central role in de novo lipogenesis in mammals. Fatty Acids 90-101 fatty acid synthase Bos taurus 0-19 16734679-1 2006 Fatty acid synthase (FASN) is a multifunctional protein that carries out the synthesis of fatty acids so it plays a central role in de novo lipogenesis in mammals. Fatty Acids 90-101 fatty acid synthase Bos taurus 21-25