PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30460485-2	2019	Various reports have highlighted the involvement of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) in the regulation of mitochondrial fatty acid oxidation, which has also been linked with DM.	Fatty Acids	152-162	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	109-115	
27845231-13	2017	Induction of HMGCS2, which is normally expressed only in the fetal and newborn heart, may indicate an adaptation by the heart to combat "metabolic inflexibility" by shifting the flux of excess intramitochondrial acetyl-CoA derived from elevated fatty acid oxidation into ketone bodies, liberating free CoA to balance the acetyl-CoA/CoA ratio in favor of increased glucose oxidation through the pyruvate dehydrogenase complex.	Fatty Acids	245-255	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	13-19	
15254779-1	2004	Hepatic mitochondrial outer membrane carnitine palmitoyltransferase I (CPT I) and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) enzymes play a key role in regulation of fatty acid oxidation and in ketogenic pathways, respectively.	Fatty Acids	196-206	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	137-153	
3741427-3	1986	The activity of HMG-CoA synthase was non-detectable in BAT indicating that this tissue, unlike liver, cannot produce ketone bodies from fatty acid oxidation but, since the tissue possesses a high activity of HMG-CoA lyase, it might produce ketone bodies from leucine catabolism.	Fatty Acids	136-146	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	16-32	
26396156-9	2016	Additionally, transcript levels of Pparalpha, and its targets acyl-CoA oxidase (Acox1) and hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), were also downregulated, indicating changes in peroxisomal fatty acid oxidation and ketogenesis.	Fatty Acids	200-210	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	132-138