PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28697636-1	2018	Delta-5 (D5D) and delta-6 (D6D) desaturase are key enzymes in fatty acid (FA) metabolism.	Fatty Acids	62-72	fatty acid desaturase 2	Mus musculus	18-30	
35421603-0	2022	Inhibition of Delta-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content.	Fatty Acids	41-51	fatty acid desaturase 2	Mus musculus	14-32	
35421603-7	2022	In addition, analyses of cellular protein markers, as well as non-esterified fatty acids and glycerol release in medium, suggested an increase in lipolysis and a decrease in fatty acid re-esterification in D6D-inhibited cells, independent of n-3 PUFA changes.	Fatty Acids	77-88	fatty acid desaturase 2	Mus musculus	206-209	
35421603-7	2022	In addition, analyses of cellular protein markers, as well as non-esterified fatty acids and glycerol release in medium, suggested an increase in lipolysis and a decrease in fatty acid re-esterification in D6D-inhibited cells, independent of n-3 PUFA changes.	Fatty Acids	174-184	fatty acid desaturase 2	Mus musculus	206-209	
35421603-10	2022	Collectively, this study provides new insight showing that D6D inhibition reduces TAG accumulation and fatty acid re-esterification in adipocytes independent of changes in n-3 PUFA cellular content.	Fatty Acids	103-113	fatty acid desaturase 2	Mus musculus	59-62	
35173101-6	2022	Conversely, unsaturated fatty acids decreased with stress treatment, which appeared to be a result of these fatty acids being the substrate of Delta-6 desaturase.	Fatty Acids	108-119	fatty acid desaturase 2	Mus musculus	143-161	
30923750-4	2019	Alterations in the D6D enzyme activity alters fatty acid profiles and are associated with metabolic and inflammatory diseases including cardiovascular disease and type 2 diabetes.	Fatty Acids	46-56	fatty acid desaturase 2	Mus musculus	19-22	
30368227-7	2019	Fads2-/- mice fed an ALA-enriched diet had reduced body weight, little-to-no omega-3 LC-PUFA and a near complete loss of all omega-3 derived oxylipins in both epididymal and inguinal WAT (P<.05) compared to their WT counterparts, as well as altered expression of key regulators of the fatty acid desaturase pathway.	Fatty Acids	288-298	fatty acid desaturase 2	Mus musculus	0-5	
2029550-0	1991	Modification of liver fatty acid metabolism in mice by n-3 and n-6 delta 6-desaturase substrates and products.	Fatty Acids	22-32	fatty acid desaturase 2	Mus musculus	67-85	
11792729-8	2002	The data suggested that D5D and D6D expression is dually regulated by SREBP-1c and PPARalpha, two reciprocal transcription factors for fatty acid metabolism, and could be involved in lipogenic gene regulation by producing PUFA.	Fatty Acids	135-145	fatty acid desaturase 2	Mus musculus	32-35	
24184513-5	2014	We then examined the effect of siRNA-mediated knockdown of fatty acid desaturases and elongases on the level of Mead acid, and found that knockdown of Elovl5, Fads1, or Fads2 decreased the level of Mead acid.	Fatty Acids	59-69	fatty acid desaturase 2	Mus musculus	169-174	
26694605-8	2016	Expression of Fads1 (Delta5 desaturase) and Fads2 (Delta6 desaturase) was elevated by the high MUFA and reduced by the high SFA diet.	Fatty Acids	124-127	fatty acid desaturase 2	Mus musculus	44-49	
26694605-8	2016	Expression of Fads1 (Delta5 desaturase) and Fads2 (Delta6 desaturase) was elevated by the high MUFA and reduced by the high SFA diet.	Fatty Acids	124-127	fatty acid desaturase 2	Mus musculus	57-68	
10827210-3	2000	On the basis of earlier fatty acid composition studies, we hypothesized that the Delta-6 desaturase pathway was essential for the production of the fatty acid regulator of gene expression.	Fatty Acids	24-34	fatty acid desaturase 2	Mus musculus	81-99	
10827210-3	2000	On the basis of earlier fatty acid composition studies, we hypothesized that the Delta-6 desaturase pathway was essential for the production of the fatty acid regulator of gene expression.	Fatty Acids	148-158	fatty acid desaturase 2	Mus musculus	81-99	
10827210-7	2000	The fatty acid composition changes elicited by ETYA were accompanied by a decrease in the enzymatic activity of Delta-6 desaturase.	Fatty Acids	4-14	fatty acid desaturase 2	Mus musculus	112-130