PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20060814-8 2010 We suggest that IL-6 is important for promoting myelin synthesis in aged females, and that drugs which inhibit the synthesis of IL-6 in males may inadvertently affect fatty acid metabolism and augment aging-related neuroinflammation. Fatty Acids 167-177 interleukin 6 Mus musculus 128-132 15599400-5 2004 In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin, plasminogen activator inhibitor-1, IL-6, and monocyte chemotactic protein-1. Fatty Acids 43-54 interleukin 6 Mus musculus 264-268 19258660-9 2008 IL-6 ablation increases fatty acid transporter expression and intramuscular lipid accumulation, particularly the saturated fatty acids. Fatty Acids 113-134 interleukin 6 Mus musculus 0-4 15382116-5 2004 The beneficial effects of IL-6 treatment in vivo resulted in part from an increase in mitochondrial beta oxidation of fatty acid and an increase in hepatic export of triglyceride and cholesterol. Fatty Acids 118-128 interleukin 6 Mus musculus 26-30 11595651-1 2001 Chronic secretion of interleukin-6 (IL-6) in mice causes metabolic alteration in the liver, leading to increased synthesis of hepatic cholesterol and fatty acids (FA). Fatty Acids 150-161 interleukin 6 Mus musculus 21-34 11595651-1 2001 Chronic secretion of interleukin-6 (IL-6) in mice causes metabolic alteration in the liver, leading to increased synthesis of hepatic cholesterol and fatty acids (FA). Fatty Acids 150-161 interleukin 6 Mus musculus 36-40 29808705-6 2020 Results The cetylated fatty acids mixture from Celadrin significantly decreased the production of IL-6, MCP-1, and TNF, key regulators of the inflammatory process, in stimulated RAW264.7 mouse macrophage cells. Fatty Acids 22-33 interleukin 6 Mus musculus 98-102 33046674-8 2020 Fatty acids transcriptionally controlled the expression of the immune-associated genes; iNOS, IL-1beta, IL-6, COX-2, and TNF-alpha, via the MAPK and NF-kappaB signaling cascades in RAW264.7 cells. Fatty Acids 0-11 interleukin 6 Mus musculus 104-108 32538719-5 2021 In addition, we evaluated the production of major cytokines (Interleukin-6 and -10) related with inflammation and fatty acid composition of several tissues. Fatty Acids 114-124 interleukin 6 Mus musculus 61-82 30032721-3 2020 To elucidate this mechanism, the effect of fatty acids on the expression of the pro-inflammatory cytokines IL-6 and TNFalpha was investigated in the mHypoE-N42 hypothalamic cell line (N42). Fatty Acids 43-54 interleukin 6 Mus musculus 107-111 29808705-8 2020 Conclusion The cetylated fatty acids mixture from Celadrin reduces inflammation in vitro by significantly decreasing the expression of IL-6, MCP-1, and TNF in stimulated RAW264.7 mouse macrophage cells. Fatty Acids 25-36 interleukin 6 Mus musculus 135-139 30383412-7 2019 In both control and free fatty acid-treated hepatocytes, IL-6 (20 ng/ml, 75 min) slightly attenuated insulin-stimulated (10 nM; ~15 min) AKT phosphorylation. Fatty Acids 25-35 interleukin 6 Mus musculus 57-61 29253016-6 2017 Non-exercised IL-6 MKO mice had higher plasma lactate and lower plasma non-esterified fatty acids than Controls. Fatty Acids 86-97 interleukin 6 Mus musculus 14-18 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Fatty Acids 18-21 interleukin 6 Mus musculus 50-54 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Fatty Acids 18-21 interleukin 6 Mus musculus 189-193 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Fatty Acids 128-131 interleukin 6 Mus musculus 189-193 26750868-2 2016 IL-6 participates in the regulation of fatty acid metabolism in the liver. Fatty Acids 39-49 interleukin 6 Mus musculus 0-4 27166928-7 2016 Investigated fatty acids changed mRNA levels of IL6 and MCP1 in young, mature and old cells. Fatty Acids 13-24 interleukin 6 Mus musculus 48-51 27327080-2 2016 IL-6 is produced in skeletal muscle during exercise in a duration dependent manner and has been reported to increase whole body fatty acid oxidation, muscle glucose uptake and decrease PDHa activity in skeletal muscle of fed mice. Fatty Acids 128-138 interleukin 6 Mus musculus 0-4 21725996-11 2011 Resistance to steatosis in these mice is attributable to elevation of inflammation-associated hepatic IL-6/STAT3 activation that subsequently down-regulates lipogenic genes but up-regulates fatty acid oxidation-associated genes in the liver. Fatty Acids 190-200 interleukin 6 Mus musculus 102-106 26578392-9 2016 In mouse primary hepatocyte cultures, IL-6 and TNFalpha inhibited high-glucose plus insulin-induced activation of SREBP-1-mediated lipogenic signaling and biosynthesis of non-esterified fatty acid and triglyceride. Fatty Acids 186-196 interleukin 6 Mus musculus 38-42 25968579-1 2015 Members of the IL-6 family, IL-6 and ciliary neurotrophic factor (CNTF), have been shown to increase glucose uptake and fatty acid oxidation in skeletal muscle. Fatty Acids 120-130 interleukin 6 Mus musculus 15-19 25968579-1 2015 Members of the IL-6 family, IL-6 and ciliary neurotrophic factor (CNTF), have been shown to increase glucose uptake and fatty acid oxidation in skeletal muscle. Fatty Acids 120-130 interleukin 6 Mus musculus 28-32 25660446-6 2015 Il-6 overexpression elevated mRNA levels of lipolysis genes, triggered phosphorylation of STAT3, AMPK, and ACC, and increased expression of genes involved in fatty acid oxidation in skeletal muscle. Fatty Acids 158-168 interleukin 6 Mus musculus 0-4 26035386-1 2015 Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Fatty Acids 61-71 interleukin 6 Mus musculus 0-13 26035386-1 2015 Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Fatty Acids 61-71 interleukin 6 Mus musculus 15-19 22623023-4 2012 In the present study we examined fatty acid (FAT/CD36, FABPpm, FATP-1, FATP-4) as well as glucose (GLUT-1, GLUT-4) transporters expression in IL-6 KO mice. Fatty Acids 33-43 interleukin 6 Mus musculus 142-146 21348853-8 2011 Interestingly, CPT1A protected against fatty acid-induced insulin resistance and expression of pro-inflammatory adipokines such as TNF-alpha (tumour necrosis factor-alpha) and IL-6 (interleukin-6) in adipocytes. Fatty Acids 39-49 interleukin 6 Mus musculus 176-180 21765602-7 2011 Levels of interleukin-6, which is associated with the enhancement of fatty acid oxidation, was also increased significantly in the livers of ethanol-fed Fyn-/- mice. Fatty Acids 69-79 interleukin 6 Mus musculus 10-23 21348853-8 2011 Interestingly, CPT1A protected against fatty acid-induced insulin resistance and expression of pro-inflammatory adipokines such as TNF-alpha (tumour necrosis factor-alpha) and IL-6 (interleukin-6) in adipocytes. Fatty Acids 39-49 interleukin 6 Mus musculus 182-195