PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34119888-5 2021 When induced with free fatty acid (FFA), cells exhibit significantly higher level of lipid accumulation (6.6 folds for in situ perfusion vs 4.4 folds for pre-differentiation), altered glucose regulation and reduced Akt phosphorylation in the organoids. Fatty Acids 23-33 AKT serine/threonine kinase 1 Homo sapiens 215-218 34718375-8 2021 In conclusion, this study revealed that epicatechin gallate impairs the synthesis of fatty acids via inhibition PI3K/AKT/mTOR signaling pathway and then attenuates the migration of prostate cancer cells. Fatty Acids 85-96 AKT serine/threonine kinase 1 Homo sapiens 117-120 33755174-0 2021 Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells. Fatty Acids 0-10 AKT serine/threonine kinase 1 Homo sapiens 90-93 35235781-4 2022 We find that NAE1 is a potential drug target for subtype iP-1, and a series of key molecules in fatty acid metabolism, such as AKT1/FASN, are plausible targets for subtype iP-2. Fatty Acids 96-106 AKT serine/threonine kinase 1 Homo sapiens 127-131 35157107-0 2022 Differential effects of single fatty acids and fatty acid mixtures on the phosphoinositide 3-kinase/Akt/eNOS pathway in endothelial cells. Fatty Acids 31-42 AKT serine/threonine kinase 1 Homo sapiens 100-103 35157107-0 2022 Differential effects of single fatty acids and fatty acid mixtures on the phosphoinositide 3-kinase/Akt/eNOS pathway in endothelial cells. Fatty Acids 47-57 AKT serine/threonine kinase 1 Homo sapiens 100-103 35157107-2 2022 Non-esterified fatty acids (NEFA) enriched in saturated fatty acids (SFA) are thought to reduce vascular reactivity by attenuating insulin signalling via vasodilator pathways (phosphoinositide 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS)) and enhancing signalling via pro-inflammatory pathways. Fatty Acids 15-26 AKT serine/threonine kinase 1 Homo sapiens 209-212 35157107-2 2022 Non-esterified fatty acids (NEFA) enriched in saturated fatty acids (SFA) are thought to reduce vascular reactivity by attenuating insulin signalling via vasodilator pathways (phosphoinositide 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS)) and enhancing signalling via pro-inflammatory pathways. Fatty Acids 46-67 AKT serine/threonine kinase 1 Homo sapiens 209-212 35157107-8 2022 CONCLUSION: Our findings provide novel insights into the modulation of the PI3K/Akt/eNOS pathway by single fatty acids and fatty acid mixtures. Fatty Acids 107-118 AKT serine/threonine kinase 1 Homo sapiens 80-83 35157107-8 2022 CONCLUSION: Our findings provide novel insights into the modulation of the PI3K/Akt/eNOS pathway by single fatty acids and fatty acid mixtures. Fatty Acids 123-133 AKT serine/threonine kinase 1 Homo sapiens 80-83 35092683-0 2022 Corrigendum to "Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells". Fatty Acids 16-26 AKT serine/threonine kinase 1 Homo sapiens 106-109 35046108-8 2022 In summary, our data revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARalpha. Fatty Acids 72-82 AKT serine/threonine kinase 1 Homo sapiens 155-158 32194897-0 2020 Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-beta/Smad3 signaling and promoting angiogenesis. Fatty Acids 0-10 AKT serine/threonine kinase 1 Homo sapiens 74-77 33716662-2 2021 Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-activated protein kinase (AMPK) inhibition and activation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR). Fatty Acids 97-107 AKT serine/threonine kinase 1 Homo sapiens 232-235 32481546-0 2020 Epidermal Growth Factor Stimulates Fatty Acid Synthesis Mainly via PLC-gamma1/Akt Signaling Pathway in Dairy Goat Mammary Epithelial Cells. Fatty Acids 35-45 AKT serine/threonine kinase 1 Homo sapiens 78-81 32481546-10 2020 These observations implied that EGFR plays an important role in regulating de novo fatty acid synthesis in GMECs, mainly mediated by Akt and PLC-gamma1 signaling pathways. Fatty Acids 83-93 AKT serine/threonine kinase 1 Homo sapiens 133-136 32312965-6 2020 We identified that binding of COL11A1 to its receptors, alpha1beta1 integrin and discoidin domain receptor 2 (DDR2), activates Src-Akt-AMPK signaling to increase the expression of both fatty acid synthesis and oxidation enzymes, although DDR2 seems to be the predominant receptor. Fatty Acids 185-195 AKT serine/threonine kinase 1 Homo sapiens 131-134 32312965-8 2020 Taken together, our results suggest that COL11A1 upregulates fatty acid metabolism in ovarian cancer cells in a DDR2-Src-Akt-AMPK dependent manner. Fatty Acids 61-71 AKT serine/threonine kinase 1 Homo sapiens 121-124 32194897-8 2020 Our findings suggest that FAs can promote cutaneous wound healing by inducing angiogenesis, partly by activating AKT, ERK, and TGF-beta/Smad3 signaling. Fatty Acids 26-29 AKT serine/threonine kinase 1 Homo sapiens 113-116 31819192-5 2020 (2) The mechanisms through which molecular heterogeneity and oncogenic signal transduction pathways, such as PI3K-AKT-mTOR signalling, regulate fatty acid metabolism. Fatty Acids 144-154 AKT serine/threonine kinase 1 Homo sapiens 114-117 31746305-0 2020 Coumarin- Fatty Acid Conjugates as Potential ERalpha/AKT-1 Antagonists for ER Positive Breast Cancer. Fatty Acids 10-20 AKT serine/threonine kinase 1 Homo sapiens 53-58 30339883-7 2019 PI3K/Akt/mTOR signaling pathway was shown to be responsible for the accumulation of intracellular lipids by regulating fatty acid synthesis, which in turn controlled senescence. Fatty Acids 119-129 AKT serine/threonine kinase 1 Homo sapiens 5-8 32072901-3 2020 This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity. Fatty Acids 135-146 AKT serine/threonine kinase 1 Homo sapiens 192-195 31332162-10 2019 These results indicate that SLAMF3 upregulation is associated with T-cell activation and cytokine production in T2D patients, and suggest that elevated saturated fatty acids in T2D patients may induce SLAMF3 upregulation on T cells via activation of the STAT5-PI3K/Akt signaling pathway. Fatty Acids 152-173 AKT serine/threonine kinase 1 Homo sapiens 265-268 30985894-4 2019 Further study in porcine mammary epithelial cells (PMECs) confirmed that valine upregulated the phosphorylation levels of AKT-activated MTOR and subsequently induced the nuclear accumulation of sterol regulatory element binding protein 1 (SREBP1), thus increasing the expression of proteins related to fatty acids synthesis and intracellular triacylglycerol content. Fatty Acids 302-313 AKT serine/threonine kinase 1 Homo sapiens 122-125 29323924-0 2018 Akt Serine/Threonine Kinase 1 Regulates de Novo Fatty Acid Synthesis through the Mammalian Target of Rapamycin/Sterol Regulatory Element Binding Protein 1 Axis in Dairy Goat Mammary Epithelial Cells. Fatty Acids 48-58 AKT serine/threonine kinase 1 Homo sapiens 0-29 29720254-7 2018 Further, the decreased levels of acetyl CoA and dependency of acetyl CoA acetyl transferase protein on AKT1 kinase activity was also found to perturb the synthesis rate of palmitic acid which is a representative of fatty acid. Fatty Acids 215-225 AKT serine/threonine kinase 1 Homo sapiens 103-107 26956906-5 2016 Meanwhile, these PI3K-Akt-mTOR inhibitors reduced intracellular lipid accumulation, decreased the mRNA expression and protein content of genes involved in the de novo fatty acid synthesis, while increased the transcriptional and protein level of key factors involved in fatty acid oxidation and very low density lipoprotein (VLDL) assembly and secretion. Fatty Acids 167-177 AKT serine/threonine kinase 1 Homo sapiens 22-25 28273470-3 2017 (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling. Fatty Acids 24-45 AKT serine/threonine kinase 1 Homo sapiens 148-151 27878243-10 2017 Additionally, both AKT1 KO and AKT2 KO demonstrated an impaired fatty acid metabolism. Fatty Acids 64-74 AKT serine/threonine kinase 1 Homo sapiens 19-23 26956906-5 2016 Meanwhile, these PI3K-Akt-mTOR inhibitors reduced intracellular lipid accumulation, decreased the mRNA expression and protein content of genes involved in the de novo fatty acid synthesis, while increased the transcriptional and protein level of key factors involved in fatty acid oxidation and very low density lipoprotein (VLDL) assembly and secretion. Fatty Acids 270-280 AKT serine/threonine kinase 1 Homo sapiens 22-25 26956906-6 2016 CONCLUSION: These findings suggested that the reduction of lipids accumulation induced-by inhibiting PI3K-Akt-mTOR pathway was closely linked to the decrease of lipogenesis, the increase of fatty acids oxidation, and the increase of VLDL assembly and secretion in goose hepatocytes. Fatty Acids 190-201 AKT serine/threonine kinase 1 Homo sapiens 106-109 27104558-14 2016 Our study demonstrated that insulin strongly protected against SFA-induced lipotoxicity in hepatocytes mechanistically through alleviating ER stress via a PI3K/Akt/p53 involved pathway but independently from autophagy. Fatty Acids 63-66 AKT serine/threonine kinase 1 Homo sapiens 160-163 27292634-5 2016 A transcriptomic, metabolomic, and phosphoproteomic study revealed that this metabolic switch is mediated by downregulation of HIF1alpha and AKT and upregulation of AMPK, allowing uptake and degradation of fatty acids and ketone bodies. Fatty Acids 206-217 AKT serine/threonine kinase 1 Homo sapiens 141-144 25957914-0 2015 Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway. Fatty Acids 73-83 AKT serine/threonine kinase 1 Homo sapiens 145-148 26698173-1 2016 In vivo, ectopic accumulation of fatty acids in muscles leads to alterations in insulin signaling at both the IRS1 and Akt steps. Fatty Acids 33-44 AKT serine/threonine kinase 1 Homo sapiens 119-122 26698173-2 2016 However, in vitro treatments with saturated fatty acids or their derivative ceramide demonstrate an effect only at the Akt step. Fatty Acids 34-55 AKT serine/threonine kinase 1 Homo sapiens 119-122 26335364-0 2015 Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. Fatty Acids 23-33 AKT serine/threonine kinase 1 Homo sapiens 59-62 26282231-0 2015 CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways. Fatty Acids 17-27 AKT serine/threonine kinase 1 Homo sapiens 81-84 25957914-13 2015 These results provide new insights into the negative regulation of miR-451 in fatty acid-induced inflammation via the AMPK/AKT pathway and demonstrate potential therapeutic applications for miR-451 in preventing the progression from simple steatosis to severely advanced liver disease. Fatty Acids 78-88 AKT serine/threonine kinase 1 Homo sapiens 123-126 25964336-7 2015 Interestingly, large-scale expression data, target analysis, and metabolic flux assays suggest this let-7-driven CM maturation could be a result of down-regulation of the phosphoinositide 3 kinase (PI3K)/AKT protein kinase/insulin pathway and an up-regulation of fatty acid metabolism. Fatty Acids 263-273 AKT serine/threonine kinase 1 Homo sapiens 204-207 25938832-0 2015 [Role of PI3K/Akt pathway in endoplasmic reticulum stress and apoptosis induced by saturated fatty acid in human steatotic hepatocytes]. Fatty Acids 83-103 AKT serine/threonine kinase 1 Homo sapiens 14-17 25793412-4 2015 In contrast, the fatty acid mixtures only modestly impaired insulin-stimulated pAktThr308M/Akt, and we found no differences between NORM and HSFA. Fatty Acids 17-27 AKT serine/threonine kinase 1 Homo sapiens 80-83 25535334-3 2015 Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation (FAO) pathways. Fatty Acids 71-81 AKT serine/threonine kinase 1 Homo sapiens 0-3 25938832-8 2015 CONCLUSION: The PI3K/Akt pathway may be involved in regulation of the UPR and non-UPR signaling pathways of endoplasmic reticulum stress and may promote apoptosis of hepatocytes by enhancing the expression of CHOP and Bax protein in saturated fatty acid-induced steatotic hepatocytes. Fatty Acids 233-253 AKT serine/threonine kinase 1 Homo sapiens 21-24 22923231-0 2013 Genetic downregulation of receptor-interacting protein 140 uncovers the central role of Akt signalling in the regulation of fatty acid oxidation in skeletal muscle cells. Fatty Acids 124-134 AKT serine/threonine kinase 1 Homo sapiens 88-91 23794138-8 2013 The analyses showed that only the phosphorylation of Akt was significantly increased in response to fatty acid treatment. Fatty Acids 100-110 AKT serine/threonine kinase 1 Homo sapiens 53-56 23989724-9 2013 The fatty acid also inhibited insulin-stimulated Akt phosphorylation and glycogen synthesis. Fatty Acids 4-14 AKT serine/threonine kinase 1 Homo sapiens 49-52 23671091-2 2013 The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. Fatty Acids 39-49 AKT serine/threonine kinase 1 Homo sapiens 11-14 19480565-7 2009 Furthermore, fatty acid treatment led to phosphorylation of downstream signalling molecules, including Akt and Erk. Fatty Acids 13-23 AKT serine/threonine kinase 1 Homo sapiens 103-106 20017192-2 2010 This protection is intrinsic, not due to changes in complement regulatory proteins, and requires activation of Akt and sterol receptor element binding protein-1 (SREBP-1), which regulates fatty acid and phospholipid synthesis. Fatty Acids 188-198 AKT serine/threonine kinase 1 Homo sapiens 111-114 19477653-0 2009 Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3beta pathway. Fatty Acids 22-36 AKT serine/threonine kinase 1 Homo sapiens 92-95 19477653-7 2009 Our study thus demonstrates that the resveratrol aliphatic acid inhibits cell apoptosis through TLR2 by the involvement of Akt/GSK3beta pathway. Fatty Acids 49-63 AKT serine/threonine kinase 1 Homo sapiens 123-126 15806154-6 2005 Compared to control cells, Akt-expressing cells were impaired in the ability to induce fatty acid oxidation in response to glucose deprivation unless stimulated with AICAR. Fatty Acids 87-97 AKT serine/threonine kinase 1 Homo sapiens 27-30 18070348-9 2007 Akt, a potential transcriptional target of Stat3, was identified as an important participant in Stat3 mediated pathways including Jak-Stat signaling, apoptosis, Mapk signaling, cholesterol and fatty acid biosynthesis. Fatty Acids 193-203 AKT serine/threonine kinase 1 Homo sapiens 0-3 16452198-5 2006 Analysis of upstream signal transduction showed that within 5 minutes of fatty acid addition, phosphatidylinositol 3-kinase (PI3K) was significantly activated followed by activation of Akt at 30 minutes. Fatty Acids 73-83 AKT serine/threonine kinase 1 Homo sapiens 185-188 15806154-0 2005 The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Fatty Acids 95-105 AKT serine/threonine kinase 1 Homo sapiens 26-29 17299765-7 2007 Additionally, we show that stimulation of fatty acid synthesizing enzymes is mediated by the PI3K/Akt signaling pathway. Fatty Acids 42-52 AKT serine/threonine kinase 1 Homo sapiens 98-101 16007182-0 2005 PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Fatty Acids 69-79 AKT serine/threonine kinase 1 Homo sapiens 0-3 16007182-0 2005 PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Fatty Acids 69-79 AKT serine/threonine kinase 1 Homo sapiens 4-7 16007182-4 2005 It has been postulated that constitutive activation of the phosphatidylinositol 3 kinase/Akt pathway may be involved in fatty acid and cholesterol accumulation that has been described in several tumour types. Fatty Acids 120-130 AKT serine/threonine kinase 1 Homo sapiens 89-92 16007182-6 2005 We identified several enzymes involved in fatty acid and cholesterol synthesis as targets for Akt-regulated transcription. Fatty Acids 42-52 AKT serine/threonine kinase 1 Homo sapiens 94-97 16007182-10 2005 Finally, activation of Akt induces an increase in the concentration of cellular fatty acids as well as phosphoglycerides, the components of cellular membranes. Fatty Acids 80-91 AKT serine/threonine kinase 1 Homo sapiens 23-26 16007182-11 2005 Our data indicate that activation of SREBP by Akt leads to the induction of key enzymes of the cholesterol and fatty acid biosynthesis pathways, and thus membrane lipid biosynthesis. Fatty Acids 111-121 AKT serine/threonine kinase 1 Homo sapiens 46-49 15806154-7 2005 Stimulation of fatty acid oxidation was sufficient to maintain cell survival as activation of fatty acid oxidation with bezafibrate also protected Akt-expressing cells from glucose withdrawal-induced death. Fatty Acids 94-104 AKT serine/threonine kinase 1 Homo sapiens 147-150 15068229-2 2004 Because fatty acids modulate insulin-stimulated Akt signaling cascades in smooth muscle cells, we hypothesized that fatty acids would differentially regulate endothelial Akt signaling, eNOS phosphorylation, and NO production. Fatty Acids 8-19 AKT serine/threonine kinase 1 Homo sapiens 48-51 15068229-2 2004 Because fatty acids modulate insulin-stimulated Akt signaling cascades in smooth muscle cells, we hypothesized that fatty acids would differentially regulate endothelial Akt signaling, eNOS phosphorylation, and NO production. Fatty Acids 116-127 AKT serine/threonine kinase 1 Homo sapiens 48-51 15068229-2 2004 Because fatty acids modulate insulin-stimulated Akt signaling cascades in smooth muscle cells, we hypothesized that fatty acids would differentially regulate endothelial Akt signaling, eNOS phosphorylation, and NO production. Fatty Acids 116-127 AKT serine/threonine kinase 1 Homo sapiens 170-173 12393870-0 2002 Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). Fatty Acids 30-40 AKT serine/threonine kinase 1 Homo sapiens 17-20 15068229-0 2004 Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway. Fatty Acids 0-11 AKT serine/threonine kinase 1 Homo sapiens 97-100