PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12049778-1 2002 Acetyl-CoA synthetase (AceCS) provides acetyl-CoA for different physiological processes, such as fatty acid and cholesterol synthesis, as well as the citric acid cycle. Fatty Acids 97-107 acyl-CoA synthetase long-chain family member 1 Mus musculus 0-21 12049778-1 2002 Acetyl-CoA synthetase (AceCS) provides acetyl-CoA for different physiological processes, such as fatty acid and cholesterol synthesis, as well as the citric acid cycle. Fatty Acids 97-107 acyl-CoA synthetase long-chain family member 1 Mus musculus 23-28 9252477-8 1997 ACS catalyzes the formation of acyl-CoA from fatty acid, and acyl-CoA is utilized for triglyceride formation in liver. Fatty Acids 45-55 acyl-CoA synthetase long-chain family member 1 Mus musculus 0-3 9804328-4 1998 In this study we determined in murine epidermis and human cultured keratinocytes the expression of three putative fatty acid transport related proteins and fatty acyl CoA synthase, an enzyme that facilitates the uptake of fatty acids by promoting their metabolism. Fatty Acids 222-233 acyl-CoA synthetase long-chain family member 1 Mus musculus 156-179 31488013-3 2019 Long-chain acyl-CoA synthetases-1, (ACSL1), is a key enzyme in the oxidative metabolism of fatty acids in mitochondria and ACSL1 may play a direct role in renal lipid deposition and promote the progress of ORN. Fatty Acids 91-102 acyl-CoA synthetase long-chain family member 1 Mus musculus 36-41 33152322-0 2020 TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Fatty Acids 97-107 acyl-CoA synthetase long-chain family member 1 Mus musculus 72-77 33152322-5 2020 In TBK1-deficient liver, ACSL1 is shifted to the endoplasmic reticulum to promote fatty acid re-esterification in lieu of oxidation in response to fasting, which accelerates hepatic lipid accumulation. Fatty Acids 82-92 acyl-CoA synthetase long-chain family member 1 Mus musculus 25-30 33285268-1 2021 Long-chain acyl-CoA synthetase-1 (ACSL1), an enzyme that catalyzes the synthesis of long-chain acyl-CoA from the corresponding fatty acids, is believed to play essential roles in lipid metabolism. Fatty Acids 127-138 acyl-CoA synthetase long-chain family member 1 Mus musculus 0-32 33285268-1 2021 Long-chain acyl-CoA synthetase-1 (ACSL1), an enzyme that catalyzes the synthesis of long-chain acyl-CoA from the corresponding fatty acids, is believed to play essential roles in lipid metabolism. Fatty Acids 127-138 acyl-CoA synthetase long-chain family member 1 Mus musculus 34-39 31488013-3 2019 Long-chain acyl-CoA synthetases-1, (ACSL1), is a key enzyme in the oxidative metabolism of fatty acids in mitochondria and ACSL1 may play a direct role in renal lipid deposition and promote the progress of ORN. Fatty Acids 91-102 acyl-CoA synthetase long-chain family member 1 Mus musculus 123-128 30677905-6 2019 The expression levels of genes related to fatty acid synthesis (ACC1, ACSL1) and oxidation (PPARalpha) in eWAT were also significantly decreased. Fatty Acids 42-52 acyl-CoA synthetase long-chain family member 1 Mus musculus 70-75 30975900-1 2019 Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (Acsl1M -/-) severely reduces acyl-CoA synthetase activity and fatty acid oxidation. Fatty Acids 145-155 acyl-CoA synthetase long-chain family member 1 Mus musculus 50-55 25383754-6 2014 The fatty acid (FA) binding and co-activator proteins Fabp1, Fabp4 and Acsl1 were increased 2-fold. Fatty Acids 4-14 acyl-CoA synthetase long-chain family member 1 Mus musculus 71-76 30580099-1 2019 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid beta-oxidation in heart, adipose tissue and skeletal muscle. Fatty Acids 65-75 acyl-CoA synthetase long-chain family member 1 Mus musculus 0-32 30580099-1 2019 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid beta-oxidation in heart, adipose tissue and skeletal muscle. Fatty Acids 65-75 acyl-CoA synthetase long-chain family member 1 Mus musculus 34-39 29092894-4 2018 METHODS AND RESULTS: Using a transgenic mouse model of cardiac lipotoxicity overexpressing ACSL1 (long-chain acyl-CoA synthetase 1) in cardiomyocytes, we show that modestly increased myocardial fatty acid uptake leads to mitochondrial structural remodeling with significant reduction in minimum diameter. Fatty Acids 194-204 acyl-CoA synthetase long-chain family member 1 Mus musculus 91-96 29092894-4 2018 METHODS AND RESULTS: Using a transgenic mouse model of cardiac lipotoxicity overexpressing ACSL1 (long-chain acyl-CoA synthetase 1) in cardiomyocytes, we show that modestly increased myocardial fatty acid uptake leads to mitochondrial structural remodeling with significant reduction in minimum diameter. Fatty Acids 194-204 acyl-CoA synthetase long-chain family member 1 Mus musculus 98-130 25784542-5 2015 This increase promoted the recruitment of peroxisome proliferator-activated receptor (PPAR)delta and PPARgamma, through desumoylation of PPARs, to the promoters of the genes involved in fatty acid oxidation (FAO), such as carnitine-palmitoyl transferase-1 (CPT1b) and long-chain acyl-CoA synthetase 1 (ACSL1). Fatty Acids 186-196 acyl-CoA synthetase long-chain family member 1 Mus musculus 268-300 25784542-5 2015 This increase promoted the recruitment of peroxisome proliferator-activated receptor (PPAR)delta and PPARgamma, through desumoylation of PPARs, to the promoters of the genes involved in fatty acid oxidation (FAO), such as carnitine-palmitoyl transferase-1 (CPT1b) and long-chain acyl-CoA synthetase 1 (ACSL1). Fatty Acids 186-196 acyl-CoA synthetase long-chain family member 1 Mus musculus 302-307 30190326-0 2018 Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways. Fatty Acids 86-97 acyl-CoA synthetase long-chain family member 1 Mus musculus 0-32 30190326-4 2018 In highly oxidative tissues, ACSL1 is located on the outer mitochondrial membrane (OMM) and directs fatty acids into mitochondria for beta-oxidation. Fatty Acids 100-111 acyl-CoA synthetase long-chain family member 1 Mus musculus 29-34 19429676-4 2009 However, ACSL1 kd adipocytes displayed a 7-fold increase in basal and a approximately 15% increase in forskolin-stimulated fatty acid efflux without any change in glycerol release, indicating a role for the protein in fatty acid reesterification following lipolysis. Fatty Acids 123-133 acyl-CoA synthetase long-chain family member 1 Mus musculus 9-14 23241406-3 2013 The objective of this study was to investigate the role of ACSL1, an ACSL isoform previously shown to mediate inflammatory effects in myeloid cells, in regulating endothelial cell responses to a saturated fatty acid-rich environment in vitro and in vivo. Fatty Acids 195-215 acyl-CoA synthetase long-chain family member 1 Mus musculus 59-64 23241406-5 2013 Forced ACSL1 overexpression exacerbated the effects of saturated fatty acids on apoptosis and endoplasmic reticulum stress. Fatty Acids 55-76 acyl-CoA synthetase long-chain family member 1 Mus musculus 7-12 22020260-6 2012 Mouse macrophages deficient in ACSL1 exhibited reduced sensitivity to oleate- and linoleate-mediated ABCA1 degradation, which resulted in increased ABCA1 levels and increased apolipoprotein A-I-dependent cholesterol efflux in the presence of these fatty acids, as compared with wildtype mouse macrophages. Fatty Acids 248-259 acyl-CoA synthetase long-chain family member 1 Mus musculus 31-36 24631848-10 2014 Compared to controls, Acsl1(H-/-) hearts exhibited an 8-fold higher uptake of 2-deoxy[1-(14)C]glucose and a 35% lower uptake of the fatty acid analog 2-bromo[1-(14)C]palmitate. Fatty Acids 132-142 acyl-CoA synthetase long-chain family member 1 Mus musculus 22-27 22308341-3 2012 This inflammatory phenotype associates with increased expression of long-chain acyl-CoA synthetase 1 (ACSL1), an enzyme that catalyzes the thioesterification of fatty acids. Fatty Acids 161-172 acyl-CoA synthetase long-chain family member 1 Mus musculus 68-100 22308341-3 2012 This inflammatory phenotype associates with increased expression of long-chain acyl-CoA synthetase 1 (ACSL1), an enzyme that catalyzes the thioesterification of fatty acids. Fatty Acids 161-172 acyl-CoA synthetase long-chain family member 1 Mus musculus 102-107 19429676-4 2009 However, ACSL1 kd adipocytes displayed a 7-fold increase in basal and a approximately 15% increase in forskolin-stimulated fatty acid efflux without any change in glycerol release, indicating a role for the protein in fatty acid reesterification following lipolysis. Fatty Acids 218-228 acyl-CoA synthetase long-chain family member 1 Mus musculus 9-14 19429676-7 2009 These findings identify a primary role of ACSL1 in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance. Fatty Acids 144-154 acyl-CoA synthetase long-chain family member 1 Mus musculus 42-47