PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27806235-1 2016 BACKGROUND: A decrease in fatty acid amide hydrolase (FAAH) activity increases the levels of endogenous analogues of cannabinoids, or endocannabinoids. Fatty Acids 26-36 fatty acid amide hydrolase Homo sapiens 54-58 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Fatty Acids 0-10 fatty acid amide hydrolase Homo sapiens 28-32 27790143-0 2016 A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs). Fatty Acids 66-76 fatty acid amide hydrolase Homo sapiens 94-98 24593280-2 2014 We have shown that fatty acid amide hydrolase (FAAH, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with BMI in healthy volunteers. Fatty Acids 19-29 fatty acid amide hydrolase Homo sapiens 47-51 24705380-2 2014 Fatty acid binding proteins (FABPs) are intracellular carriers that deliver AEA and related N-acylethanolamines (NAEs) to FAAH for hydrolysis. Fatty Acids 0-10 fatty acid amide hydrolase Homo sapiens 122-126 26901181-1 2016 Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties. Fatty Acids 114-124 fatty acid amide hydrolase Homo sapiens 0-26 26901181-1 2016 Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties. Fatty Acids 114-124 fatty acid amide hydrolase Homo sapiens 28-32 26774927-3 2016 Concomitant blockade of fatty acid amide hydrolase (FAAH) enhances the therapeutic effects of the NSAIDs while attenuating their propensity to cause gastrointestinal injury. Fatty Acids 24-34 fatty acid amide hydrolase Homo sapiens 52-56 23488865-1 2013 INTRODUCTION: Fatty acid amide hydrolase (FAAH) is the major catabolic enzyme of the endocannabinoid N-arachidonoylethanolamine (anandamide) that, with different degrees of efficiency, also hydrolyzes other endogenous fatty acid ethanolamides. Fatty Acids 218-228 fatty acid amide hydrolase Homo sapiens 14-40 23488865-1 2013 INTRODUCTION: Fatty acid amide hydrolase (FAAH) is the major catabolic enzyme of the endocannabinoid N-arachidonoylethanolamine (anandamide) that, with different degrees of efficiency, also hydrolyzes other endogenous fatty acid ethanolamides. Fatty Acids 218-228 fatty acid amide hydrolase Homo sapiens 42-46 23344792-0 2013 The interaction of fatty acid amide hydrolase (FAAH) inhibitors with an anandamide carrier protein using (19)F-NMR. Fatty Acids 19-29 fatty acid amide hydrolase Homo sapiens 47-51 18289091-5 2008 FAAH inhibitors can be divided in two major groups, the first one includes the inhibitors inspired by the chemical structures of FAAH substrates, which carry an arachidonoyl-, oleoyl- or palmitoyl-carbon chain that mimic the fatty acid chains of anandamide, oleamide and palmitoylethanolamide. Fatty Acids 225-235 fatty acid amide hydrolase Homo sapiens 0-4 23409303-1 2004 FAAH plays a key role in the hydrolysis of a number of primary and secondary fatty acid amides, controlling the levels of the neuromodulatory endocannabinoids in the ECS (3, 4). Fatty Acids 77-87 fatty acid amide hydrolase Homo sapiens 0-4 26588763-1 2013 The serine hydrolase, fatty acid amide hydrolase (FAAH), is responsible for the intracellular degradation of anandamide and other bioactive fatty acid ethanolamides involved in the regulation of pain, inflammation, and other pathophysiological processes. Fatty Acids 22-32 fatty acid amide hydrolase Homo sapiens 50-54 22473870-7 2012 The synonymous rs324419 SNP of the FAAH gene which encodes fatty acid amide hydrolase, a cannabinoid metabolizing enzyme, was associated with PD-related pain (p = 0.006) and specifically with the musculoskeletal subtype. Fatty Acids 59-69 fatty acid amide hydrolase Homo sapiens 35-39 21477106-3 2011 Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function. Fatty Acids 22-32 fatty acid amide hydrolase Homo sapiens 52-56 20152858-5 2010 As for the degradation of NAEs, fatty acid amide hydrolase (FAAH), which hydrolyzes NAEs to fatty acids and ethanolamine, plays a central role. Fatty Acids 92-103 fatty acid amide hydrolase Homo sapiens 60-64 20022504-1 2010 N-Acylethanolamines, including N-palmitoyl-ethanolamine (PEA), are hydrolyzed to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH). Fatty Acids 99-110 fatty acid amide hydrolase Homo sapiens 159-163 18851692-5 2008 RESULTS/CONCLUSION: CB(1) agonists and fatty acid amide hdyrolase (FAAH) inhibitors share mechanisms with other antidepressants: the ability to enhance central serotonergic and noradrenergic transmission and promote neurogenesis in the hippocampus. Fatty Acids 39-49 fatty acid amide hydrolase Homo sapiens 67-71 18753625-1 2008 The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Fatty Acids 29-39 fatty acid amide hydrolase Homo sapiens 57-61 18289091-5 2008 FAAH inhibitors can be divided in two major groups, the first one includes the inhibitors inspired by the chemical structures of FAAH substrates, which carry an arachidonoyl-, oleoyl- or palmitoyl-carbon chain that mimic the fatty acid chains of anandamide, oleamide and palmitoylethanolamide. Fatty Acids 225-235 fatty acid amide hydrolase Homo sapiens 129-133 17015445-8 2006 These data coupled with the overlapping, but distinct tissue distributions of FAAH-1 and FAAH-2 suggest that these proteins may collaborate to control fatty acid amide catabolism in primates. Fatty Acids 151-161 fatty acid amide hydrolase Homo sapiens 78-84 17158103-1 2007 Fatty acid amide hydrolase (FAAH) is a dimeric, membranebound enzyme that degrades neuromodulatory fatty acid amides and esters and is expressed in mammalian brain and peripheral tissues. Fatty Acids 99-109 fatty acid amide hydrolase Homo sapiens 28-32 11585048-1 2001 Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). Fatty Acids 104-114 fatty acid amide hydrolase Homo sapiens 28-32 16392827-1 2006 The demonstration of the essential role of fatty acid amide hydrolase (FAAH) in hydrolyzing endogenous bioactive fatty acid derivatives has launched the quest for the discovery of inhibitors for this enzyme. Fatty Acids 43-53 fatty acid amide hydrolase Homo sapiens 71-75 15533037-4 2004 We use this method to discover several brain lipids regulated by the mammalian enzyme fatty acid amide hydrolase (FAAH) in vivo, including known signaling molecules (e.g., the endogenous cannabinoid anandamide) and a novel family of nervous system-enriched natural products, the taurine-conjugated fatty acids. Fatty Acids 298-309 fatty acid amide hydrolase Homo sapiens 114-118 16892344-1 2006 Fatty acid amide hydrolase (FAAH) is a serine hydrolase that catalyzes the intracellular hydrolysis of fatty acid ethanolamides such as anandamide and oleoylethanolamide. Fatty Acids 103-113 fatty acid amide hydrolase Homo sapiens 28-32 34756920-3 2022 AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide, OEA). Fatty Acids 94-104 fatty acid amide hydrolase Homo sapiens 59-63 34959715-0 2021 Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review. Fatty Acids 13-23 fatty acid amide hydrolase Homo sapiens 41-45 34952353-2 2022 Elevations in one of the major endocannabinoids (anandamide) either via inhibition of the primary degrading enzyme (fatty acid amide hydrolase; FAAH) or via a genetic variation in the FAAH gene (C385A; rs324420) has resulted in accelerated extinction learning and enhanced extinction recall among healthy adults. Fatty Acids 116-126 fatty acid amide hydrolase Homo sapiens 144-148 33460184-1 2021 BACKGROUND: Reduced function of fatty acid amide hydrolase, the catabolic enzyme for the endocannabinoid anandamide, can be inherited through a functional genetic polymorphism (FAAH rs324420, C385A, P129T). Fatty Acids 32-42 fatty acid amide hydrolase Homo sapiens 177-181 34983657-4 2022 FAAH-1 is the primary enzyme accountable for the degradation of AEA and related fatty acid amides. Fatty Acids 80-90 fatty acid amide hydrolase Homo sapiens 0-6 33070154-1 2021 JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of fatty acid amides (FAA) including anandamide (AEA), palmitoylethanolamide (PEA), and N-oleoylethanolamide (OEA). Fatty Acids 41-51 fatty acid amide hydrolase Homo sapiens 69-73 34827417-3 2021 The aim of this study is two-fold: (1) to use the photopic flicker ERG to target the cone pathway specifically, and (2) use URB597 as a selective inhibitor of the endocannabinoid degrading enzyme Fatty Acid Amide Hydrolase (FAAH) to enhance the levels of fatty acid amides, particularly anandamide. Fatty Acids 196-206 fatty acid amide hydrolase Homo sapiens 224-228 34827417-3 2021 The aim of this study is two-fold: (1) to use the photopic flicker ERG to target the cone pathway specifically, and (2) use URB597 as a selective inhibitor of the endocannabinoid degrading enzyme Fatty Acid Amide Hydrolase (FAAH) to enhance the levels of fatty acid amides, particularly anandamide. Fatty Acids 255-265 fatty acid amide hydrolase Homo sapiens 224-228 32292082-1 2020 Introduction: Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme, that inactivates endogenous signaling lipids of the fatty acid amide family, including the endocannabinoid anandamide (N-arachidonoylethanolamine, AEA). Fatty Acids 128-138 fatty acid amide hydrolase Homo sapiens 14-40 32732136-2 2020 The endocannabinoid system (EC) and polymorphism in the endocannabinoid receptor type 1 (CNR1) gene 3813A/G and 4895A/G and in the fatty acid amide hydrolase (FAAH) are associated with obesity. Fatty Acids 131-141 fatty acid amide hydrolase Homo sapiens 159-163 32292082-1 2020 Introduction: Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme, that inactivates endogenous signaling lipids of the fatty acid amide family, including the endocannabinoid anandamide (N-arachidonoylethanolamine, AEA). Fatty Acids 128-138 fatty acid amide hydrolase Homo sapiens 42-46 31914367-1 2020 Fatty acid amide hydrolase (FAAH) degrades the endogenous endocannabinoid (eCB) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores (highs). Fatty Acids 0-16 fatty acid amide hydrolase Homo sapiens 28-32 32041998-1 2020 Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids. Fatty Acids 0-16 fatty acid amide hydrolase Homo sapiens 28-32 30739035-2 2019 Inhibition of fatty-acid amide hydrolase (FAAH), the major enzyme catalyzing the degradation of anandamide (AEA), an endocannabinoid, and other fatty-acid amides, suppresses pain without unwanted side effects typical of direct CB1 agonists. Fatty Acids 14-24 fatty acid amide hydrolase Homo sapiens 42-46 30929760-5 2019 Circulating concentrations of anandamide and related fatty-acid amides (palmitoylethanolamide and oleoylethanolamine) that are all normally degraded by FAAH were significantly elevated in peripheral blood compared with normal control carriers of the hypomorphic single-nucleotide polymorphism. Fatty Acids 53-63 fatty acid amide hydrolase Homo sapiens 152-156 30929760-6 2019 The genetic findings and elevated circulating fatty-acid amides are consistent with a phenotype resulting from enhanced endocannabinoid signalling and a loss of function of FAAH. Fatty Acids 46-56 fatty acid amide hydrolase Homo sapiens 173-177 31921630-2 2019 It is widely accepted that plasma levels of these three NAEs are regulated by the actions of the rate-limiting enzymes N-acylphoshatidylethanolamine-specific phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), which are synthesizing and degradative, respectively. Fatty Acids 189-205 fatty acid amide hydrolase Homo sapiens 217-221 31117309-1 2019 Fatty Acid Amide Hydrolase (FAAH) is one of the main enzymes responsible for endocannabinoid metabolism. Fatty Acids 0-10 fatty acid amide hydrolase Homo sapiens 28-32 31117309-2 2019 Inhibition of FAAH increases endogenous levels of fatty acid ethanolamides such as anandamide (AEA) and thus consitutes an indirect strategy that can be used to modulate endocannabinoid tone. Fatty Acids 50-60 fatty acid amide hydrolase Homo sapiens 14-18