PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12538081-2 2003 Recently, studies in vivo and in cell lines have shown that vitamin A and its active metabolite, retinoic acid, regulate the expression of fatty acid desaturases including stearoyl-CoA desaturase and delta-5 desaturase. Fatty Acids 139-149 fatty acid desaturase 1 Homo sapiens 200-218 10601301-0 1999 Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. Fatty Acids 25-35 fatty acid desaturase 1 Homo sapiens 60-78 12079847-7 2002 The strong relationships between the Delta5 desaturase activity, a high content of long-chain polyunsaturated fatty acids in the skeletal muscle, and insulin sensitivity may be due to parallel effects of diet and/or physical activity on the fatty acid composition and on insulin sensitivity. Fatty Acids 110-120 fatty acid desaturase 1 Homo sapiens 43-54 34189740-3 2021 This study examines the relationship between two SNPs in the FADS1 gene (rs174546, rs174537) and the fatty acid (FA) composition of serum lipids in adolescents (13-18 years). Fatty Acids 101-111 fatty acid desaturase 1 Homo sapiens 61-66 9223654-0 1997 Delta-6-desaturase and delta-5-desaturase in human Hep G2 cells are both fatty acid interconversion rate limiting and are upregulated under essential fatty acid deficient conditions. Fatty Acids 73-83 fatty acid desaturase 1 Homo sapiens 23-41 34937850-5 2022 FADS2 silencing in cancer cells leads to FADS1 synthesis of unusual fatty acids. Fatty Acids 68-79 fatty acid desaturase 1 Homo sapiens 41-46 33595419-1 2021 Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. Fatty Acids 52-62 fatty acid desaturase 1 Homo sapiens 0-23 33595419-1 2021 Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. Fatty Acids 52-62 fatty acid desaturase 1 Homo sapiens 25-30 35548952-3 2022 The FADS1 overexpression increased the triglyceride content, lipid droplet size, and expression of genes related to fatty acid de novo synthesis (SREBP1 and ACC), intracellular fatty acid transporters (FABP3 and FABP4) and triacylglycerol synthesis gene (DGAT2). Fatty Acids 116-126 fatty acid desaturase 1 Homo sapiens 4-9 34143495-5 2021 Hepatic gene expression of key enzymes of desaturation (Fads1/Fads2) of n-6 and n-3 polyunsaturated fatty acids (PUFAs), of phosphatidylethanolamine (PE) N-methyltransferase (Pemt), of fatty acid translocase Cd36, and of glucose-6-phosphate isomerase (Gpi) were quantified by Real Time-PCR. Fatty Acids 100-111 fatty acid desaturase 1 Homo sapiens 56-61 35548952-0 2022 FADS1 overexpression promotes fatty acid synthesis and triacylglycerol accumulation via inhibiting the AMPK/SREBP1 pathway in goat mammary epithelial cells. Fatty Acids 30-40 fatty acid desaturase 1 Homo sapiens 0-5 35182678-3 2022 This study was aimed to find an association between genetic variant rs174537 of fatty acid desaturase gene 1(FADS 1) and breast cancer estrogen receptor subtype. Fatty Acids 80-90 fatty acid desaturase 1 Homo sapiens 109-115 35548952-3 2022 The FADS1 overexpression increased the triglyceride content, lipid droplet size, and expression of genes related to fatty acid de novo synthesis (SREBP1 and ACC), intracellular fatty acid transporters (FABP3 and FABP4) and triacylglycerol synthesis gene (DGAT2). Fatty Acids 177-187 fatty acid desaturase 1 Homo sapiens 4-9 34997498-11 2022 The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group. Fatty Acids 150-161 fatty acid desaturase 1 Homo sapiens 100-123 34997498-11 2022 The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group. Fatty Acids 150-161 fatty acid desaturase 1 Homo sapiens 125-130 35211495-3 2021 Interactions are particularly relevant with the FADS1 and FADS2 genes, which encode key fatty acid desaturases in the pathway that converts LA and ALA to their long chain (>=20 carbons), highly unsaturated fatty acid (HUFA) counterparts. Fatty Acids 88-98 fatty acid desaturase 1 Homo sapiens 48-53 32584610-0 2020 Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population. Fatty Acids 94-105 fatty acid desaturase 1 Homo sapiens 40-45 33548080-1 2021 SCOPE: We investigated the FADS1 rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha-linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids (PLs), and markers of low-grade inflammation and glucose-insulin homeostasis. Fatty Acids 166-176 fatty acid desaturase 1 Homo sapiens 27-32 34980917-6 2022 Finally, we used interaction analyses to identify population- and lineage-specific meQTL, including rs174548 in FADS1, with the strongest effect in CD8+ T cells, thus linking fatty acid metabolism with immune dysregulation and asthma. Fatty Acids 175-185 fatty acid desaturase 1 Homo sapiens 112-117 33904180-5 2021 Through a combination of immunofluorescence, pharmacological inhibition, tracing experiments with stable isotope-labeled fatty acids, and oxidant challenge with hydrogen peroxide, we demonstrate the presence and redox-sensitive activity of FADS2, FADS1, and FADS5 in the mature RBC. Fatty Acids 121-132 fatty acid desaturase 1 Homo sapiens 247-252 33310680-1 2021 Numerous studies have reported an association between genetic variants in fatty acid desaturases (FADS1 and FADS2) and plasma or erythrocyte long chain polyunsaturated fatty acid (PUFA) levels. Fatty Acids 74-84 fatty acid desaturase 1 Homo sapiens 98-103 33331250-4 2021 The associations between rs174547 in FADS1 and seven types of fatty acids, and delta-5 (D5D) and delta-6 fatty acid desaturase (D6D) activity were assessed based on the pooled results from 11 manuscripts. Fatty Acids 62-73 fatty acid desaturase 1 Homo sapiens 37-42 33038834-7 2020 The pattern of fatty acid responses is fully consistent with specific genetic modulation of desaturation at the FADS1-mediated 20:3 20:4 step. Fatty Acids 15-25 fatty acid desaturase 1 Homo sapiens 112-117 32397743-0 2020 FADS1 Genotype Associates with Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification. Fatty Acids 66-76 fatty acid desaturase 1 Homo sapiens 0-5 32397743-12 2020 Conclusions - The association between the FADS1 genotype and AS may implicate effects on valvular fatty acids. Fatty Acids 98-109 fatty acid desaturase 1 Homo sapiens 42-47 32584610-10 2020 These data suggest that variations in FADS1, FADS2, and ELOVL2 affect the risk of overweight-obesity and the level of circulating fatty acids and could point to a key molecular pathway of metabolic syndrome and its related comorbidities. Fatty Acids 130-141 fatty acid desaturase 1 Homo sapiens 38-43 31817859-5 2019 SNPs in or close to the FADS1 gene were associated with most FAs. Fatty Acids 61-64 fatty acid desaturase 1 Homo sapiens 24-29 31690987-11 2020 However, the associations, except that for palmitoleic acid, were driven by variants in FADS1/2, which encode enzymes with a key role in fatty acid metabolism. Fatty Acids 137-147 fatty acid desaturase 1 Homo sapiens 88-95 32919185-5 2020 Delta-5 desaturase (D5D) and delta-6 desaturase (D6D) activities were determined from product-to-precursor ratios of individual fatty acids in plasma. Fatty Acids 128-139 fatty acid desaturase 1 Homo sapiens 0-18 32919185-5 2020 Delta-5 desaturase (D5D) and delta-6 desaturase (D6D) activities were determined from product-to-precursor ratios of individual fatty acids in plasma. Fatty Acids 128-139 fatty acid desaturase 1 Homo sapiens 20-23 31797636-7 2020 Seven SNPs were significant in association with dihomo-gamma-linolenic acid, of which five were within fatty acid desaturases FADS1 and FADS2. Fatty Acids 103-113 fatty acid desaturase 1 Homo sapiens 126-131 31923811-0 2020 Associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants. Fatty Acids 28-38 fatty acid desaturase 1 Homo sapiens 57-62 31923811-2 2020 The purpose of this study was to examine the associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants. Fatty Acids 73-83 fatty acid desaturase 1 Homo sapiens 102-107 31923811-4 2020 In maternal FADS1 SNP genotypes, the precursor fatty acids composition of the Delta5 desaturase in the maternal blood showed significant differences in levels among the groups, and showed increasing values in the order of TT < TC < CC genotype groups. Fatty Acids 47-58 fatty acid desaturase 1 Homo sapiens 12-17 31923811-4 2020 In maternal FADS1 SNP genotypes, the precursor fatty acids composition of the Delta5 desaturase in the maternal blood showed significant differences in levels among the groups, and showed increasing values in the order of TT < TC < CC genotype groups. Fatty Acids 47-58 fatty acid desaturase 1 Homo sapiens 84-95 31923811-7 2020 These results indicate the maternal and fetal blood fatty acid compositions are strongly influenced by the FADS1 genotypes. Fatty Acids 52-62 fatty acid desaturase 1 Homo sapiens 107-112 31567872-0 2019 FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets. Fatty Acids 60-70 fatty acid desaturase 1 Homo sapiens 0-5 31433740-0 2019 FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. Fatty Acids 39-49 fatty acid desaturase 1 Homo sapiens 0-5 31340443-1 2019 Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. Fatty Acids 50-60 fatty acid desaturase 1 Homo sapiens 0-23 30082751-0 2019 FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression. Fatty Acids 69-80 fatty acid desaturase 1 Homo sapiens 0-5 30082751-3 2019 The present study examined if SNPs in FADS1/FADS2 modify human subcutaneous adipose tissue (SAT) fatty acid profiles and the expression of genes associated with inflammation/immune function, lipid metabolism, and cellular differentiation. Fatty Acids 97-107 fatty acid desaturase 1 Homo sapiens 38-43 31340443-1 2019 Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. Fatty Acids 50-60 fatty acid desaturase 1 Homo sapiens 25-30 28501027-0 2017 Erratum to: A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution. Fatty Acids 89-99 fatty acid desaturase 1 Homo sapiens 52-57 29246731-6 2018 RESULTS: We identified 24 previously reported SNPs associated with fatty acid levels and desaturase activities as significantly associated with D5D activity within the FADS1-FADS2 gene cluster (lead SNP rs174566/A>G). Fatty Acids 67-77 fatty acid desaturase 1 Homo sapiens 168-173 29258511-9 2017 The results suggest that increased activity of C16 Delta9-desaturase and C18 Delta9-desaturase in parallel with decreased Delta5-desaturase activity may be a causative factor in disturbed fatty acid metabolism. Fatty Acids 188-198 fatty acid desaturase 1 Homo sapiens 57-68 28732058-0 2017 The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models. Fatty Acids 55-65 fatty acid desaturase 1 Homo sapiens 14-19 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Fatty Acids 91-101 fatty acid desaturase 1 Homo sapiens 589-594 30624587-3 2019 Objectives: The aim of the current study was to test the hypothesis that the FADS1 rs174550 genotype modifies the effect of dietary LA intake on the fatty acid composition of plasma lipids, fasting glucose, and high-sensitivity C-reactive protein (hsCRP). Fatty Acids 149-159 fatty acid desaturase 1 Homo sapiens 77-82 30157936-0 2018 FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression. Fatty Acids 54-64 fatty acid desaturase 1 Homo sapiens 0-5 29514873-0 2018 Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient. Fatty Acids 57-67 fatty acid desaturase 1 Homo sapiens 142-147 22503634-3 2012 To determine the importance of genetic variability to fatty-acid biosynthesis, we studied FADS1 and FADS2, which encode rate-limiting enzymes for fatty-acid conversion. Fatty Acids 146-156 fatty acid desaturase 1 Homo sapiens 90-95 28359317-0 2017 A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution. Fatty Acids 77-87 fatty acid desaturase 1 Homo sapiens 40-45 26881936-2 2016 Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase activity delta-5 desaturase (D5D ratio) have been reported, as have adverse relations with saturated fatty acids and D6D ratio. Fatty Acids 213-234 fatty acid desaturase 1 Homo sapiens 131-149 26881936-2 2016 Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase activity delta-5 desaturase (D5D ratio) have been reported, as have adverse relations with saturated fatty acids and D6D ratio. Fatty Acids 213-234 fatty acid desaturase 1 Homo sapiens 151-154 26501394-0 2016 Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. Fatty Acids 76-86 fatty acid desaturase 1 Homo sapiens 34-39 26501394-2 2016 We examined gene-diet interaction of total marine PUFA intake with a known gene encoding Delta-5 desaturase enzyme (FADS1) variant (rs174550) for fatty acids in erythrocyte membranes and plasma phospholipids (PL), cholesteryl esters (CE), and triglycerides (TG). Fatty Acids 146-157 fatty acid desaturase 1 Homo sapiens 116-121 26501394-7 2016 CONCLUSION: FADS1 variants may modulate the relationship between marine fatty acid intake and circulating levels of long-chain omega-3 fatty acids. Fatty Acids 72-82 fatty acid desaturase 1 Homo sapiens 12-17 24460221-3 2014 The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain. Fatty Acids 32-42 fatty acid desaturase 1 Homo sapiens 120-125 23419767-1 2013 Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 0-10 fatty acid desaturase 1 Homo sapiens 215-233 28436449-8 2017 The decreased activity of the desaturase FADS1 appeared as a bottleneck, leading upstream to an accumulation of fatty acids and downstream to a deficiency of long-chain fatty acids resulting to impaired phospholipid synthesis. Fatty Acids 112-123 fatty acid desaturase 1 Homo sapiens 41-46 27004414-0 2016 Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease. Fatty Acids 46-57 fatty acid desaturase 1 Homo sapiens 17-22 26346302-0 2015 Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP. Fatty Acids 11-21 fatty acid desaturase 1 Homo sapiens 69-74 26474818-2 2015 These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Delta-5 (encoded by FADS1) and Delta-6 desaturases (encoded by FADS2). Fatty Acids 6-17 fatty acid desaturase 1 Homo sapiens 129-134 25849351-1 2015 BACKGROUND: Previous studies suggested that dietary fatty acids could affect blood lipids by interacting with genetic variations in fatty acid desaturase 1 (FADS1). Fatty Acids 52-63 fatty acid desaturase 1 Homo sapiens 132-155 25849351-1 2015 BACKGROUND: Previous studies suggested that dietary fatty acids could affect blood lipids by interacting with genetic variations in fatty acid desaturase 1 (FADS1). Fatty Acids 52-63 fatty acid desaturase 1 Homo sapiens 157-162 26163647-1 2015 FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. Fatty Acids 7-17 fatty acid desaturase 1 Homo sapiens 0-5 25122663-10 2014 Additional findings include associations between endogenously synthesized fatty acids and CHD risk, which were partly explained by changes in Delta6-desaturase and Delta5-desaturase indexes, suggesting that in vivo metabolism may also play an important role in predicting CHD risk in this cohort of postmenopausal women. Fatty Acids 74-85 fatty acid desaturase 1 Homo sapiens 170-181 24847668-2 2014 The fatty acid composition is modulated by desaturases; stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 4-14 fatty acid desaturase 1 Homo sapiens 116-134 23667444-1 2013 OBJECTIVE: Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. Fatty Acids 71-81 fatty acid desaturase 1 Homo sapiens 94-99 23221573-1 2013 BACKGROUND: Desaturation of dietary alpha-linolenic acid (ALA) to omega-3 (n-3) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition. Fatty Acids 104-107 fatty acid desaturase 1 Homo sapiens 145-150 22619218-0 2012 A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. Fatty Acids 84-95 fatty acid desaturase 1 Homo sapiens 8-13 21605700-0 2011 Increased Delta5- and Delta6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. Fatty Acids 122-132 fatty acid desaturase 1 Homo sapiens 28-39 20888206-11 2012 CONCLUSION: The observed lower Delta5-desaturase activity in participants with type 2 diabetes and its inverse association with HOMA-IR suggest that changes in fatty-acid metabolism may play a role in the aetiology of type 2 diabetes. Fatty Acids 160-170 fatty acid desaturase 1 Homo sapiens 37-48 22900039-0 2012 Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue. Fatty Acids 85-95 fatty acid desaturase 1 Homo sapiens 36-41 22863834-1 2012 AIMS: Plasma fatty acid composition can change with age, reflecting diet and levels of desaturating enzymes such as stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D), which contribute to the development of insulin resistance. Fatty Acids 13-23 fatty acid desaturase 1 Homo sapiens 176-194 21605700-5 2011 These changes correlated with increased expression of fatty acid Delta5- and Delta6-desaturases, key enzymes in this metabolic pathway. Fatty Acids 54-64 fatty acid desaturase 1 Homo sapiens 83-95 21414826-1 2011 Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been examined in different ethnic populations. Fatty Acids 52-62 fatty acid desaturase 1 Homo sapiens 84-89 21414826-1 2011 Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been examined in different ethnic populations. Fatty Acids 138-148 fatty acid desaturase 1 Homo sapiens 84-89 20948998-1 2010 BACKGROUND: Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. Fatty Acids 81-91 fatty acid desaturase 1 Homo sapiens 51-56 22140540-1 2011 BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors. Fatty Acids 33-43 fatty acid desaturase 1 Homo sapiens 57-62 22140540-3 2011 METHODOLOGY/PRINCIPAL FINDINGS: Analyzing MCF7 cell fatty acids with detailed structural mass spectrometry, we show that in the absence of FADS2 activity, the FADS1 product Delta5-desaturase operates to produce 5,11,14-20:3 and 5,11,14,17-20:4. Fatty Acids 52-63 fatty acid desaturase 1 Homo sapiens 159-164 21106917-1 2011 BACKGROUND: Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Delta5-desaturase and Delta6-desaturase. Fatty Acids 221-232 fatty acid desaturase 1 Homo sapiens 260-271 21106917-1 2011 BACKGROUND: Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Delta5-desaturase and Delta6-desaturase. Fatty Acids 234-237 fatty acid desaturase 1 Homo sapiens 260-271 21106917-2 2011 Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic acid (AA) amounts. Fatty Acids 129-132 fatty acid desaturase 1 Homo sapiens 47-52 21307609-2 2011 Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D) modulate fatty acid composition and are thus associated with the development of metabolic syndrome. Fatty Acids 116-126 fatty acid desaturase 1 Homo sapiens 82-100 18479586-0 2009 Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Fatty Acids 60-70 fatty acid desaturase 1 Homo sapiens 110-115 19797200-4 2010 Delta-9-desaturase and Delta-5-desaturase activities were estimated based on serum fatty acid compositions. Fatty Acids 83-93 fatty acid desaturase 1 Homo sapiens 23-41 18479586-1 2009 The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. Fatty Acids 250-261 fatty acid desaturase 1 Homo sapiens 149-154 18296339-6 2008 High saturated fatty acid levels are known for their propensity to interfere with delta-6 and delta-5 desaturase activities and this is reflected in the blood profile of the RLP patients. Fatty Acids 5-25 fatty acid desaturase 1 Homo sapiens 82-112 18222430-7 2008 RESULT(S): Genes involved in fatty acid synthesis, such as stearoyl-CoA desaturase, fatty acid synthase, acetyl-coenzyme A carboxylase alpha, and fatty acid desaturase 1 were decreased by estrogen treatment in a subgroup of women. Fatty Acids 29-39 fatty acid desaturase 1 Homo sapiens 146-169 18626191-5 2008 Our data demonstrate for the first time that the fatty acid composition of serum phospholipids is genetically controlled by the FADS1 FADS2 gene cluster. Fatty Acids 49-59 fatty acid desaturase 1 Homo sapiens 128-133 17852835-5 2007 When FAs were added after 72 h, further upregulation during the next 24 h was suppressed for nearly all desaturases and FAs tested, except for D5D when oleic acid (OA) or stearic acid (SA) was added. Fatty Acids 5-8 fatty acid desaturase 1 Homo sapiens 143-146 16670158-0 2006 Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Fatty Acids 115-125 fatty acid desaturase 1 Homo sapiens 31-36 16670158-2 2006 We report strong associations between variants in the human delta-5 and delta-6 desaturase genes FADS1 FADS2 and fatty acid composition in serum phospholipids. Fatty Acids 113-123 fatty acid desaturase 1 Homo sapiens 97-102